scholarly journals Executive functioning in Alzheimer's disease and vascular dementia

Author(s):  
B. McGuinness ◽  
S. L. Barrett ◽  
D. Craig ◽  
J. Lawson ◽  
A. P. Passmore
Author(s):  
Larry Tune

Dementia refers to a large number of disorders characterized by global cognitive deficits, including impairments of recent memory, and one or more of the following: aphasia, apraxia, agnosia, and disturbance of executive functioning. The most common dementias are Alzheimer’s disease (AD), vascular dementia, dementia due to general medical conditions (including HIV dementia), head trauma, Parkinson’s disease (PD), Huntington’s disease, Pick’s disease, Creutzfeldt-Jakob disease, substance-induced persisting dementia, and multiple etiologies. Alzheimer’s disease, alone or in combination with other conditions (e.g., stroke), is easily the most common. With the exception of dementia associated with Parkinson’s disease, the remaining syndromes are either so rare or heterogeneous that it is difficult to find well-controlled studies that would meet diagnostic and clinical design criteria for standards defined for this book. The focus of this chapter is on therapeutic interventions for Alzheimer’s disease. Innumerable articles investigating patient populations defined as “geropsychiatric” or “gerontopsychiatric” have been excluded. Following this discussion, there is a brief review of therapeutic interventions for Parkinson’s disease.


2011 ◽  
Author(s):  
Beyon H. Miloyan ◽  
Justina Avila ◽  
Inna Ghajoyan ◽  
Jill Razani

Author(s):  
Burbaeva G.Sh. ◽  
Androsova L.V. ◽  
Vorobyeva E.A. ◽  
Savushkina O.K.

The aim of the study was to evaluate the rate of polymerization of tubulin into microtubules and determine the level of colchicine binding (colchicine-binding activity of tubulin) in the prefrontal cortex in schizophrenia, vascular dementia (VD) and control. Colchicine-binding activity of tubulin was determined by Sherlinе in tubulin-enriched extracts of proteins from the samples. Measurement of light scattering during the polymerization of the tubulin was carried out using the nephelometric method at a wavelength of 450-550 nm. There was a significant decrease in colchicine-binding activity and the rate of tubulin polymerization in the prefrontal cortex in both diseases, and in VD to a greater extent than in schizophrenia. The obtained results suggest that not only in Alzheimer's disease, but also in other mental diseases such as schizophrenia and VD, there is a decrease in the level of tubulin in the prefrontal cortex of the brain, although to a lesser extent than in Alzheimer's disease, and consequently the amount of microtubules.


2016 ◽  
Vol 12 (3) ◽  
pp. 226-237 ◽  
Author(s):  
Ghulam M. Ashraf ◽  
Sandesh Chibber ◽  
. Mohammad ◽  
Syed K. Zaidi ◽  
Shams Tabrez ◽  
...  

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