scholarly journals Effect of timed bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease

2005 ◽  
Vol 20 (8) ◽  
pp. 738-743 ◽  
Author(s):  
Glenna A. Dowling ◽  
Judy Mastick ◽  
Erin M. Hubbard ◽  
Jay S. Luxenberg ◽  
Robert L. Burr
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Bright Light ◽  
Light Treatment ◽  
Institutionalized Patients ◽  
Rest Activity ◽  
Bright Light Treatment

scholarly journals Melatonin and Bright-Light Treatment for Rest–Activity Disruption in Institutionalized Patients with Alzheimer's Disease

2008 ◽  
Vol 56 (2) ◽  
pp. 239-246 ◽  
Author(s):  
Glenna A. Dowling ◽  
Robert L. Burr ◽  
Eus J. W. Van Someren ◽  
Erin M. Hubbard ◽  
Jay S. Luxenberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Bright Light ◽  
Light Treatment ◽  
Institutionalized Patients ◽  
Bright Light Treatment

scholarly journals Effects of Light Treatment on Sleep, Cognition, Mood, and Behavior in Alzheimer’s Disease: A Systematic Review

2018 ◽  
Vol 46 (5-6) ◽  
pp. 371-384 ◽  
Author(s):  
Micaela Mitolo ◽  
Caterina Tonon ◽  
Chiara La Morgia ◽  
Claudia Testa ◽  
Valerio Carelli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Task Force ◽  
Critical Evaluation ◽  
Bright Light ◽  
Light Treatment ◽  
Intervention Treatment ◽  
And Behavior ◽  
Bright Light Treatment

Background: Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer’s disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusions have been drawn about its specific therapeutic effect. Summary: The aim of this review is to provide a critical evaluation of available evidence in this field, highlighting the specific characteristics of effective bright light treatment. Eligible studies were required to assess at least one of the following outcome measures: sleep, cognition, mood, and/or behavior (e.g., depression, agitation). A total of 32 articles were included in this systematic review and identified as research intervention studies about light treatment in AD. The quality of the papers was evaluated based on the US Preventive Service Task Force guidelines. Key Messages: Overall, the current literature suggests that the effects of light treatment in AD patients are mixed and may be influenced by several factors, but with a general trend toward a positive effect. Bright light seems to be a promising intervention treatment without significant adverse effects; therefore, further well-designed randomized controlled trials are needed taking into account the highlighted recommendations.

scholarly journals Effect of morning bright light treatment for rest–activity disruption in institutionalized patients with severe Alzheimer's disease

2005 ◽  
Vol 17 (2) ◽  
pp. 221-236 ◽  
Author(s):  
Glenna A. Dowling ◽  
Erin M. Hubbard ◽  
Judy Mastick ◽  
Jay S. Luxenberg ◽  
Robert L. Burr ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Light Exposure ◽  
Activity Rhythm ◽  
Bright Light ◽  
Wake Time ◽  
Institutionalized Patients ◽  
Nighttime Sleep ◽  
Bright Light Exposure ◽  
Rest Activity

Background: Disturbances in rest–activity rhythm are prominent and disabling symptoms in Alzheimer's disease (AD). Nighttime sleep is severely fragmented and daytime activity is disrupted by multiple napping episodes. In most institutional environments, light levels are very low and may not be sufficient to enable the circadian clock to entrain to the 24-hour day. The purpose of this randomized, placebo-controlled, clinical trial was to test the effectiveness of morning bright light therapy in reducing rest–activity (circadian) disruption in institutionalized patients with severe AD.Method: Subjects (n=46, mean age 84 years) meeting the NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke – the Alzheimer's Disease and Related Disorders Association) AD diagnostic criteria were recruited from two large, skilled nursing facilities in San Francisco, California. The experimental group received one hour (09:30–10:30) of bright light exposure (≥2500lux in gaze direction) Monday through Friday for 10weeks. The control group received usual indoor light (150–200lux). Nighttime sleep efficiency, sleep time, wake time and number of awakenings and daytime wake time were assessed using actigraphy. Circadian rhythm parameters were also determined from the actigraphic data using cosinor analysis and nonparametric techniques. Repeated measures analysis of variance (ANOVA) was used to test the primary study hypotheses.Results and conclusion: Although significant improvements were found in subjects with aberrant timing of their rest–activity rhythm, morning bright light exposure did not induce an overall improvement in measures of sleep or the rest–activity in all treated as compared to control subjects. The results indicate that only subjects with the most impaired rest–activity rhythm respond significantly and positively to a brief (one hour) light intervention.

scholarly journals The Effect of Bright Light Treatment on Rest–Activity Rhythms in People with Dementia: A 24-Week Cluster Randomized Controlled Trial

2021 ◽  
Vol 3 (3) ◽  
pp. 449-464
Author(s):  
Eirin Kolberg ◽  
Ståle Pallesen ◽  
Gunnhild Johnsen Hjetland ◽  
Inger Hilde Nordhus ◽  
Elisabeth Flo-Groeneboom
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Bright Light ◽  
Light Treatment ◽  
Activity Rhythms ◽  
Randomized Controlled ◽  
People With Dementia ◽  
Rest Activity ◽  
Non Parametric ◽  
Bright Light Treatment

Bright light treatment is an effective way to influence circadian rhythms in healthy adults, but previous research with dementia patients has yielded mixed results. The present study presents a primary outcome of the DEM.LIGHT trial, a 24-week randomized controlled trial conducted at nursing homes in Bergen, Norway, investigating the effects of a bright light intervention. The intervention consisted of ceiling-mounted LED panels providing varying illuminance and correlated color temperature throughout the day, with a peak of 1000 lx, 6000 K between 10 a.m. and 3 p.m. Activity was recorded using actigraphs at baseline and after 8, 16, and 24 weeks. Non-parametric indicators and extended cosine models were used to investigate rest–activity rhythms, and outcomes were analyzed with multi-level regression models. Sixty-one patients with severe dementia (median MMSE = 4) were included. After 16 weeks, the acrophase was advanced from baseline in the intervention group compared to the control group (B = −1.02, 95%; CI = −2.00, −0.05). There was no significant difference between the groups on any other rest–activity measures. When comparing parametric and non-parametric indicators of rest–activity rhythms, 25 out of 35 comparisons were significantly correlated. The present results indicate that ambient bright light treatment did not improve rest–activity rhythms for people with dementia.

scholarly journals Effects of High-Frequency Cranial Electrostimulation on the Rest-Activity Rhythm and Salivary Cortisol in Alzheimer’s Disease

2006 ◽  
Vol 22 (4) ◽  
pp. 267-272 ◽  
Author(s):  
Erik Scherder ◽  
Dirk Knol ◽  
Marie-Jose van Tol ◽  
Eus van Someren ◽  
Jan-Berend Deijen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Salivary Cortisol ◽  
High Frequency ◽  
Activity Rhythm ◽  
Rest Activity

Clock drawing test in institutionalized patients with schizophrenia compared with Alzheimer's disease patients

2003 ◽  
Vol 59 (2-3) ◽  
pp. 173-179 ◽  
Author(s):  
Vasilis P Bozikas ◽  
Mary H Kosmidis ◽  
Anastasios Kourtis ◽  
Katerina Gamvrula ◽  
Petros Melissidis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Drawing Test ◽  
Institutionalized Patients
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