Glial fibrillary acidic protein in the fish optic nerve

Glia ◽  
1991 ◽  
Vol 4 (4) ◽  
pp. 393-399 ◽  
Author(s):  
Eran Blaugrund ◽  
Ilana Cohen ◽  
Yael Shani ◽  
Michal Schwartz
Keyword(s):  
Optic Nerve ◽  
Glial Fibrillary Acidic Protein ◽  
Acidic Protein

Expression of glial fibrillary acidic protein (GFAP) in goldfish optic nerve following injury

Glia ◽  
1990 ◽  
Vol 3 (1) ◽  
pp. 33-42 ◽  
Author(s):  
C. A. Stafford ◽  
S. A. S. Shehab ◽  
S. N. Nona ◽  
J. R. Cronly-Dillon
Keyword(s):  
Optic Nerve ◽  
Glial Fibrillary Acidic Protein ◽  
Acidic Protein

Neuroprotective effects of topical coenzyme Q10 + vitamin E in mechanic optic nerve injury model

2019 ◽  
Vol 30 (4) ◽  
pp. 714-722 ◽  
Author(s):  
Selcan Ekicier Acar ◽  
M Sinan Sarıcaoğlu ◽  
Aysel Çolak ◽  
Zeynep Aktaş ◽  
Aylin Sepici Dinçel
Keyword(s):  
Optic Nerve ◽  
Treatment Group ◽  
Glial Fibrillary Acidic Protein ◽  
Protein Expression ◽  
Nerve Injury ◽  
Acidic Protein ◽  
Optic Nerve Injury ◽  
Neuroprotective Effects ◽  
Sham Treatment ◽  
Injury Model

Purpose: We aimed to create mechanic optic nerve injury model in rats and investigate the neuroprotective effects of topical Coenzyme Q10 + Vitamin E (CoQ + Vit.E) molecules on retinal ganglion cells. Methods: Mechanic optic nerve injury model was created in the right eyes of rats (n = 12). Rats were divided into two groups: glaucoma model with sham treatment and topical CoQ + Vit.E treatment. Treatment was applied for 4 weeks. Glial fibrillary acidic protein, Brn-3a antibody, and anti-Iba1 were examined by immunohistochemistry. Glial fibrillary acidic protein, Bax, Bcl-xL, and Tfam protein expression were measured by Western blot analysis. Results: The number of Brn-3a-positive retinal ganglion cell was 15.0 ± 1.0 (min: 14, max: 16) in sham treatment group and 22.2 ± 4.8 (min: 18, max: 29) in topical CoQ10 + Vit.E treatment group. The protection of Brn-3a in CoQ10 + Vit.E was statistically significant (p < 0.05). Glial fibrillary acidic protein–positive astroglial counts were recorded as 11.7 ± 2.1 (min: 10, max: 14) in sham treatment and 2.5 ± 1.5 (min: 1, max: 4) in topical CoQ10 + Vit.E treatment group (p < 0.05). Topical CoQ10 + Vit.E treatment also decreased Iba1 expression in the retina of mechanic optic nerve injury groups. CoQ10 + Vit.E treatment prevented apoptotic cell death by increasing Bcl-xL protein expression. Also, CoQ10 + Vit.E preserved Tfam protein expression in the retina. Conclusion: This study has shown that in glaucoma treatment the neuron protecting effect of topical CoQ10 + Vit.E molecules can be valuable.

Glial fibrillary acidic protein (GFAP) and CD34 expression in the human optic nerve and brain in methanol toxicity

2008 ◽  
Vol 25 (2) ◽  
pp. 123-132 ◽  
Author(s):  
Nursel Türkmen ◽  
Bülent Eren ◽  
Recep Fedakar ◽  
Semra Akgöz ◽  
Nil Çomunoğlu
Keyword(s):  
Optic Nerve ◽  
Glial Fibrillary Acidic Protein ◽  
Acidic Protein ◽  
Human Optic Nerve ◽  
Cd34 Expression

Immunocytochemical localization of taurine and glial fibrillary acidic protein in human optic nerve

1992 ◽  
Vol 8 (3) ◽  
pp. 251-255 ◽  
Author(s):  
Norma Lake ◽  
Carole Verdone-Smith ◽  
Seymour Brownstein
Keyword(s):  
Optic Nerve ◽  
Bovine Serum Albumin ◽  
Glial Fibrillary Acidic Protein ◽  
Glial Cells ◽  
Branching Processes ◽  
Acidic Protein ◽  
Specific Marker ◽  
Immunocytochemical Localization ◽  
Glia Limitans ◽  
Human Optic Nerve

AbstractTaurine immunoreactivity (IR) in 1 -μm sections of glutaraldehyde-fixed human optic nerve was observed using light microscopy and an antibody raised in rabbit to taurine conjugated to bovine serum albumin. Throughout the nerve, taurine-lR was prominent in glial cells, in their perinuclear regions, and in their numerous branching processes, some of which extended to the pial septa. The peripheral glial mantle (glia limitans) was densely stained, whereas axons and the pial septa showed relatively little or no taurine-IR. Immunoreactivity for glial fibrillary acidic protein (GFAP), an astrocyte-specific marker, was evaluated on adjacent sections. The pattern of GFAP-IR was highly similar to that for taurine, suggesting that a subset of taurine-immunoreactive glial cells are optic nerve astrocytes. To our knowledge, this is the first localization of taurine and GFAP in human optic nerve.

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