DHHC5 facilitates oligodendrocyte development by palmitoylating and activating STAT3

Glia ◽  
2021 ◽  
Author(s):  
Yanchen Ma ◽  
Huiqing Liu ◽  
Zhimin Ou ◽  
Chen Qi ◽  
Rui Xing ◽  
...  
Keyword(s):  
Oligodendrocyte Development

scholarly journals Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Arpna Srivastava ◽  
Krishan Kumar ◽  
Jyotirmoy Banerjee ◽  
Manjari Tripathi ◽  
Vivek Dubey ◽  
...  
Keyword(s):  
Rna Sequencing ◽  
Focal Cortical Dysplasia ◽  
Phospholipid Metabolism ◽  
Cortical Dysplasia ◽  
Type Ii ◽  
Tissue Samples ◽  
Significant Enrichment ◽  
Gene Expression Studies ◽  
Oligodendrocyte Development ◽  
High Throughput Gene Expression

AbstractFocal cortical dysplasia (FCD) is a malformation of the cerebral cortex with poorly-defined epileptogenic zones (EZs), and poor surgical outcome in FCD is associated with inaccurate localization of the EZ. Hence, identifying novel epileptogenic markers to aid in the localization of EZ in patients with FCD is very much needed. High-throughput gene expression studies of FCD samples have the potential to uncover molecular changes underlying the epileptogenic process and identify novel markers for delineating the EZ. For this purpose, we, for the first time performed RNA sequencing of surgically resected paired tissue samples obtained from electrocorticographically graded high (MAX) and low spiking (MIN) regions of FCD type II patients and autopsy controls. We identified significant changes in the MAX samples of the FCD type II patients when compared to non-epileptic controls, but not in the case of MIN samples. We found significant enrichment for myelination, oligodendrocyte development and differentiation, neuronal and axon ensheathment, phospholipid metabolism, cell adhesion and cytoskeleton, semaphorins, and ion channels in the MAX region. Through the integration of both MAX vs non-epileptic control and MAX vs MIN RNA sequencing (RNA Seq) data, PLP1, PLLP, UGT8, KLK6, SOX10, MOG, MAG, MOBP, ANLN, ERMN, SPP1, CLDN11, TNC, GPR37, SLC12A2, ABCA2, ABCA8, ASPA, P2RX7, CERS2, MAP4K4, TF, CTGF, Semaphorins, Opalin, FGFs, CALB2, and TNC were identified as potential key regulators of multiple pathways related to FCD type II pathology. We have identified novel epileptogenic marker elements that may contribute to epileptogenicity in patients with FCD and could be possible markers for the localization of EZ.

scholarly journals Life-long oligodendrocyte development and plasticity

2021 ◽  
Author(s):  
Akiko Nishiyama ◽  
Takahiro Shimizu ◽  
Amin Sherafat ◽  
William D. Richardson
Keyword(s):  
Oligodendrocyte Development

scholarly journals Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate

2011 ◽  
Vol 31 (2) ◽  
pp. 538-548 ◽  
Author(s):  
J. E. Rinholm ◽  
N. B. Hamilton ◽  
N. Kessaris ◽  
W. D. Richardson ◽  
L. H. Bergersen ◽  
...  
Keyword(s):  
Oligodendrocyte Development

scholarly journals Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retina

2006 ◽  
Vol 290 (2) ◽  
pp. 277-286 ◽  
Author(s):  
Limin Gao ◽  
Wendy Macklin ◽  
James Gerson ◽  
Robert H. Miller
Keyword(s):  
Rat Retina ◽  
Oligodendrocyte Development

scholarly journals Stage-Specific Regulation of Oligodendrocyte Development by Wnt/ -Catenin Signaling

2014 ◽  
Vol 34 (25) ◽  
pp. 8467-8473 ◽  
Author(s):  
Z.-M. Dai ◽  
S. Sun ◽  
C. Wang ◽  
H. Huang ◽  
X. Hu ◽  
...  
Keyword(s):  
Specific Regulation ◽  
Oligodendrocyte Development
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