Blocking Kallikrein 6 promotes developmental myelination

Glia ◽  
2021 ◽  
Author(s):  
Hyesook Yoon ◽  
Erin M. Triplet ◽  
Whitney L. Simon ◽  
Chan‐Il Choi ◽  
Laurel S. Kleppe ◽  
...  
Keyword(s):  
Kallikrein 6

scholarly journals Expression and biological significance of human kallikrein 6 in gastric cancer tissues

2013 ◽  
Vol 1 ◽  
pp. 64-67
Author(s):  
Cheng Jin Hu ◽  
Kui Xiang Chen ◽  
Jin Feng Zheng ◽  
Ying Jian Chen
Keyword(s):  
Gastric Cancer ◽  
Biological Significance ◽  
Cancer Tissues ◽  
Kallikrein 6

scholarly journals Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer

2017 ◽  
Vol 109 (4) ◽  
Author(s):  
Laurent Briollais ◽  
Hilmi Ozcelik ◽  
Jingxiong Xu ◽  
Maciej Kwiatkowski ◽  
Emilie Lalonde ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Germline Mutations ◽  
Aggressive Prostate Cancer ◽  
Kallikrein 6

scholarly journals Human Kallikrein 6 Expression in Salivary Gland Tumors

2006 ◽  
Vol 54 (3) ◽  
pp. 337-342 ◽  
Author(s):  
M.R. Darling ◽  
L. Jackson-Boeters ◽  
T.D. Daley ◽  
E.P. Diamandis
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumors ◽  
Kallikrein 6

Reference intervals and biological variation for kallikrein 6: influence of age and renal failure

2012 ◽  
Vol 50 (5) ◽  
Author(s):  
Eduardo Martínez-Morillo ◽  
Anastasia Diamandis ◽  
Eleftherios P. Diamandis
Keyword(s):  
Renal Failure ◽  
Significant Positive Correlation ◽  
Reference Interval ◽  
Serum Marker ◽  
Reference Intervals ◽  
Biological Variation ◽  
Serum Samples ◽  
Positive Correlation ◽  
Reference Change Value ◽  
Kallikrein 6

AbstractKallikrein 6 (KLK6) is a serine protease involved in numerous cellular processes, up-regulated in many cancers and associated with some neurodegenerative disorders. The aim of this study was to establish a reference interval and estimate the biological variation of KLK6 in serum samples of adults. Furthermore, levels of this protein in patients with renal failure were also studied.Serum samples from healthy volunteers (n=136) were collected. Between 15 and 18 additional samples from four of these subjects were obtained over a period of 2 months. Samples from individuals (n=1043) who visited the University Health Network for a routine check-up were collected to study the association between KLK6 with age and gender. Samples from patients with renal failure (n=106) were also obtained and KLK6 and creatinine concentrations were analyzed by ELISA and an automated enzymatic method, respectively.The reference interval was established to be 1.04–3.93 ng/mL. The index of individuality was 0.43 and the reference change value was 35%. Only two serum samples would be required to estimate the homeostatic setting point of an individual. There is a weak but highly significant positive correlation between KLK6 and age (p<0.0001). Furthermore, there is a significant positive correlation between serum concentrations of KLK6 and creatinine (p<0.0001), in patients with renal failure.The established reference interval for KLK6 and the estimation of its biological variation will further aid in the clinical use of this protein as a serum marker of malignancy and other diseases.

scholarly journals 909 Kallikrein 6 (KLK6) mediated keratin 10 degradation is required for VZV propagation in skin

2018 ◽  
Vol 138 (5) ◽  
pp. S154
Author(s):  
C. Tommasi ◽  
J. Breuer ◽  
R. O'Shaughnessy
Keyword(s):  
Kallikrein 6

Dynamic role of kallikrein 6 in traumatic spinal cord injury

2006 ◽  
Vol 24 (5) ◽  
pp. 1457-1469 ◽  
Author(s):  
I. A. Scarisbrick ◽  
P. Sabharwal ◽  
H. Cruz ◽  
N. Larsen ◽  
A. G. Vandell ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury ◽  
Kallikrein 6

scholarly journals Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease

2004 ◽  
Vol 91 (6) ◽  
pp. 1439-1449 ◽  
Author(s):  
G. P. Christophi ◽  
P. J. Isackson ◽  
S. Blaber ◽  
M. Blaber ◽  
M. Rodriguez ◽  
...  
Keyword(s):  
Differential Expression ◽  
Demyelinating Disease ◽  
Tissue Specific ◽  
Kallikrein 6

Germline mutations in the Kallikrein 6 region and predisposition for aggressive prostate cancer

2017 ◽  
Vol 16 (3) ◽  
pp. e624-e625
Author(s):  
L. Briollais ◽  
H. Ozcelik ◽  
J. Xu ◽  
M. Kwiatkowski ◽  
E. Lalonde ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Germline Mutations ◽  
Aggressive Prostate Cancer ◽  
Kallikrein 6
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