scholarly journals Increasing astrogenesis in the developing hippocampus induces autistic‐like behavior in mice via enhancing inhibitory synaptic transmission

Glia ◽  
2021 ◽  
Author(s):  
Juan Chen ◽  
Xiao‐Lin Ma ◽  
Hui Zhao ◽  
Xiao‐Yu Wang ◽  
Min‐Xin Xu ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Inhibitory Synaptic Transmission

Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy

2016 ◽  
Vol 86 ◽  
pp. 109-120 ◽  
Author(s):  
Marco Fuenzalida ◽  
Claudia Espinoza ◽  
Miguel Ángel Pérez ◽  
Cheril Tapia-Rojas ◽  
Loreto Cuitino ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Mouse Model ◽  
Synaptic Transmission ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Inhibitory Synaptic Transmission

Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy

Blood ◽  
2003 ◽  
Vol 102 (4) ◽  
pp. 1525-1528 ◽  
Author(s):  
Brian J. Ruscito ◽  
Neil L. Harrison
Keyword(s):  
Cognitive Impairment ◽  
Hepatic Encephalopathy ◽  
Synaptic Transmission ◽  
Liver Failure ◽  
Gabaa Receptor ◽  
Protoporphyrin Ix ◽  
Aminobutyric Acid ◽  
Endogenous Ligands ◽  
Inhibitory Synaptic Transmission ◽  
Clinical Observations

Abstract Liver failure is often accompanied by cognitive impairment and coma, a syndrome known as hepatic encephalopathy (HE). The administration of flumazenil, a benzodiazepine (BZ) antagonist, is effective in reversing the symptoms of HE in many patients. These clinical observations gave rise to notions of an endogenous BZ-like mechanism in HE, but to date no viable candidate compounds have been characterized. We show here that the hemoglobin (Hb) metabolites hemin and protoporphyrin IX (PPIX) interact with the BZ site on the γ-aminobutyric acid (GABAA) receptor and enhance inhibitory synaptic transmission in a manner similar to diazepam and zolpidem. This finding suggests that hemin and PPIX are neuroactive porphyrins capable of acting as endogenous ligands for the central BZ site. The accumulation of these porphyrins under pathophysiologic conditions provides a potentially novel mechanism for the central manifestations of HE.

Substance P stimulates inhibitory synaptic transmission in the guinea pig basolateral amygdala in vitro

2001 ◽  
Vol 40 (6) ◽  
pp. 806-817 ◽  
Author(s):  
Karen A Maubach ◽  
Karine Martin ◽  
David W Smith ◽  
Louise Hewson ◽  
Robert A Frankshun ◽  
...  
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Synaptic Transmission ◽  
Basolateral Amygdala ◽  
Inhibitory Synaptic Transmission
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