scholarly journals Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury

Glia ◽  
2021 ◽  
Vol 69 (12) ◽  
pp. 2882-2898
Author(s):  
Aresh Sahu ◽  
Sulochana Devi ◽  
Jonathan Jui ◽  
Daniel Goldman
Keyword(s):  
Notch Signaling ◽  
Regenerative Response ◽  
Retinal Injury

scholarly journals Notch signaling via Hey1 and Id2b regulates Müller glia’s regenerative response to retinal injury

2021 ◽  
Author(s):  
Aresh Sahu ◽  
Sulochana Devi ◽  
Jonathan Jui ◽  
Daniel Goldman
Keyword(s):  
Notch Signaling ◽  
Response Threshold ◽  
Müller Glia ◽  
Injury Response ◽  
Neuron Death ◽  
Regenerative Response ◽  
Retinal Injury ◽  
Downstream Effectors ◽  
Notch Inhibition ◽  
Focal Injury

AbstractUnlike mammals, zebrafish can regenerate a damaged retina. Key to this regenerative response are Müller glia (MG) that divide and produce progenitors for retinal repair. Although factors regulating MG’s decision to divide remain mostly unknown, a certain threshold of neuron death must be exceeded in order for MG to engage in a regenerative response. A role for Notch signaling in this process is indicated since its inhibition expands the zone of injury-responsive MG following a focal injury. Our data show that injury-dependent changes in Dll4 and Dlb control Notch signaling in MG and that Hey1 and Id2b are downstream effectors that regulate proliferation of MG and MG-derived progenitors. Although we find Hey1 and Id2b can inhibit proliferation of MG-derived progenitors, only Hey1 is able to regulate MG’s injury response threshold. Remarkably, Hey1 suppression is sufficient to recapitulate the effects of Notch inhibition on MG’s injury response threshold.

scholarly journals Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Mi-Sun Lee ◽  
Jin Wan ◽  
Daniel Goldman
Keyword(s):  
Notch Signaling ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Neuronal Degeneration ◽  
Muller Glia ◽  
Müller Glia ◽  
Retina Regeneration ◽  
Retinal Injury ◽  
Multipotent Progenitors ◽  
Tgfb Signaling

Neuronal degeneration in the zebrafish retina stimulates Müller glia (MG) to proliferate and generate multipotent progenitors for retinal repair. Controlling this proliferation is critical to successful regeneration. Previous studies reported that retinal injury stimulates pSmad3 signaling in injury-responsive MG. Contrary to these findings, we report pSmad3 expression is restricted to quiescent MG and suppressed in injury-responsive MG. Our data indicates that Tgfb3 is the ligand responsible for regulating pSmad3 expression. Remarkably, although overexpression of either Tgfb1b or Tgfb3 can stimulate pSmad3 expression in the injured retina, only Tgfb3 inhibits injury-dependent MG proliferation; suggesting the involvement of a non-canonical Tgfb signaling pathway. Furthermore, inhibition of Alk5, PP2A or Notch signaling rescues MG proliferation in Tgfb3 overexpressing zebrafish. Finally, we report that this Tgfb3 signaling pathway is active in zebrafish MG, but not those in mice, which may contribute to the different regenerative capabilities of MG from fish and mammals.

The Role of Activated NOTCH Signaling in Childhood T-ALL

2010 ◽  
Vol 223 (01) ◽  
Author(s):  
AE Kulozik ◽  
C Kox ◽  
M Remke ◽  
S Breit ◽  
M Zimmermann ◽  
...  
Keyword(s):  
Notch Signaling

Notch signaling participates in liver fibrosis

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
HL Weng ◽  
Y Liu ◽  
Z Shen ◽  
MY Xu ◽  
R Liebe ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Notch Signaling

Recombinant Probiotics Expressing Angiotensin-(1-7) Improves Glucose Metabolism and Diabetes-Induced Renal and Retinal Injury

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 33-LB ◽  
Author(s):  
QIUHONG LI ◽  
KANG XU ◽  
TAO DU ◽  
PING ZHU ◽  
AMRISHA VERMA
Keyword(s):  
Glucose Metabolism ◽  
Retinal Injury

New insights into mechanism of Notch signaling in hidradenitis suppurativa

2020 ◽  
Vol 155 (4) ◽  
Author(s):  
Emanuele Scala ◽  
Anna Balato ◽  
Claudio Marasca ◽  
Roberta Di Caprio ◽  
Annunziata Raimondo ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Hidradenitis Suppurativa
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