Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression

Glia ◽  
2021 ◽  
Author(s):  
Anna Simankova ◽  
Norihisa Bizen ◽  
Sei Saitoh ◽  
Shinsuke Shibata ◽  
Nobuhiko Ohno ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dead Box ◽  
Myelin Gene

In vivo modulation of myelin gene expression by human recombinant IL-2

1992 ◽  
Vol 12 (4) ◽  
pp. 331-334 ◽  
Author(s):  
Maria Sessa ◽  
Raffaello Nemni ◽  
Sandro Iannaccone ◽  
Angelo Quattrini ◽  
Valeria Confalonieri ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myelin Gene

scholarly journals The RNA helicase DDX5 promotes alveolar rhabdomyosarcoma growth and survival

2020 ◽  
Author(s):  
Alberto Gualtieri ◽  
Valerio Licursi ◽  
Chiara Mozzetta
Keyword(s):  
Gene Expression ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Therapeutic Target ◽  
Rna Helicase ◽  
Potential Therapeutic Target ◽  
Growth And Survival ◽  
Dead Box ◽  
Pharmacological Targets ◽  
Xenograft Models

AbstractRhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood characterized by the inability to exit the proliferative myoblast-like stage. The alveolar fusion positive subtype (FP-ARMS) is the most aggressive and is mainly caused by the expression of PAX3/7-FOXO1 oncoproteins, which are challenging pharmacological targets. Thus, other therapeutic vulnerabilities resulting from gene expression changes are progressively being recognized. Here, we identified the DEAD box RNA helicase 5 (DDX5) as a potential therapeutic target to inhibit FP-ARMS growth. We show that DDX5 is overexpressed in alveolar RMS cells, demonstrating that its depletion drastically decreases FP-ARMS viability and slows tumor growth in xenograft models. Mechanistically, we provide evidence that DDX5 functions upstream the G9a/AKT survival signalling pathway, by modulating G9a protein stability. Finally, we show that G9a interacts with PAX3-FOXO1 and regulates its activity, thus sustaining FP-ARMS myoblastic state. Together, our findings identify a novel survival-promoting loop in FP-ARMS and highlight DDX5 as potential therapeutic target to arrest rhabdomyosarcoma growth.

scholarly journals Wnt/ -Catenin Signaling Is an Essential and Direct Driver of Myelin Gene Expression and Myelinogenesis

2011 ◽  
Vol 31 (10) ◽  
pp. 3729-3742 ◽  
Author(s):  
M. Tawk ◽  
J. Makoukji ◽  
M. Belle ◽  
C. Fonte ◽  
A. Trousson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myelin Gene

Stimulation of myelin gene expression in vitro and of sciatic nerve remyelination by interleukin-6 receptor-interleukin-6 chimera

2001 ◽  
Vol 64 (6) ◽  
pp. 564-574 ◽  
Author(s):  
S. Haggiag ◽  
P.-L. Zhang ◽  
G. Slutzky ◽  
V. Shinder ◽  
A. Kumar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sciatic Nerve ◽  
Interleukin 6 ◽  
Interleukin 6 Receptor ◽  
Myelin Gene ◽  
Stimulation Of

scholarly journals Central myelin gene expression during postnatal development in rats exposed to nicotine gestationally

2013 ◽  
Vol 553 ◽  
pp. 115-120 ◽  
Author(s):  
Junran Cao ◽  
Jennifer B. Dwyer ◽  
Nicole M. Gautier ◽  
Frances M. Leslie ◽  
Ming D. Li
Keyword(s):  
Gene Expression ◽  
Postnatal Development ◽  
Central Myelin ◽  
Myelin Gene

A novel transcriptional regulator of myelin gene expression: implications for neurodevelopmental disorders

Neuroreport ◽  
2010 ◽  
Vol 21 (14) ◽  
pp. 917-921 ◽  
Author(s):  
Parvez Vora ◽  
Raena Mina ◽  
Michael Namaka ◽  
Emma E. Frost
Keyword(s):  
Gene Expression ◽  
Neurodevelopmental Disorders ◽  
Transcriptional Regulator ◽  
Myelin Gene

scholarly journals A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players

2006 ◽  
Vol 25 (20) ◽  
pp. 4833-4842 ◽  
Author(s):  
Aixiao Liu ◽  
Jiadong Li ◽  
Mireya Marin-Husstege ◽  
Ryochiro Kageyama ◽  
Yongjun Fan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dependent Inhibition ◽  
Myelin Gene
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