scholarly journals Glutamate transporter 1‐expressing glia in the rat substantia nigra—Morphometric analysis and relationships to synapses

Glia ◽  
2020 ◽  
Vol 68 (10) ◽  
pp. 2028-2039
Author(s):  
Jean‐Pierre Kessler ◽  
Pascal Salin ◽  
Lydia Kerkerian‐Le Goff
Keyword(s):  
Substantia Nigra ◽  
Morphometric Analysis ◽  
Glutamate Transporter ◽  
Glutamate Transporter 1 ◽  
Rat Substantia Nigra

Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra

2006 ◽  
Vol 23 (4) ◽  
pp. 1063-1070 ◽  
Author(s):  
Raquel Martín-Ibañez ◽  
Monica Jenstad ◽  
Paul Berghuis ◽  
Robert H. Edwards ◽  
Hiroyuki Hioki ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Glutamate Transporter ◽  
Vesicular Glutamate Transporter ◽  
Rat Substantia Nigra

scholarly journals Endocytosis of the glutamate transporter 1 is regulated by laforin and malin: Implications in Lafora disease

Glia ◽  
2020 ◽  
Author(s):  
Eva Perez‐Jimenez ◽  
Rosa Viana ◽  
Carmen Muñoz‐Ballester ◽  
Carlos Vendrell‐Tornero ◽  
Raquel Moll‐Diaz ◽  
...  
Keyword(s):  
Glutamate Transporter ◽  
Lafora Disease ◽  
Glutamate Transporter 1

Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra

1998 ◽  
Vol 51 (2) ◽  
pp. 196-209 ◽  
Author(s):  
Wolfgang L�scher ◽  
Ulrich Ebert ◽  
Holger Lehmann ◽  
Christoph Rosenthal ◽  
Guido Nikkhah
Keyword(s):  
Substantia Nigra ◽  
Gabaergic Neurons ◽  
Rat Substantia Nigra ◽  
Seizure Suppression

scholarly journals Activation of Glutamate Transporter-1 (GLT-1) Confers Sex-Dependent Neuroprotection in Brain Ischemia

2021 ◽  
Vol 11 (1) ◽  
pp. 76
Author(s):  
Flavia A. Tejeda-Bayron ◽  
David E. Rivera-Aponte ◽  
Christian J. Malpica-Nieves ◽  
Gerónimo Maldonado-Martínez ◽  
Héctor M. Maldonado ◽  
...  
Keyword(s):  
Infarct Size ◽  
Glutamate Transporter ◽  
Triphenyltetrazolium Chloride ◽  
Stroke Outcomes ◽  
Female Mice ◽  
Protein Levels ◽  
Translational Activator ◽  
Glutamate Transporter 1 ◽  
Sensorimotor Performance

Stroke is one of the leading causes of long-term disability. During ischemic stroke, glutamate is released, reuptake processes are impaired, and glutamate promotes excitotoxic neuronal death. Astrocytic glutamate transporter 1 (GLT-1) is the major transporter responsible for removing excess glutamate from the extracellular space. A translational activator of GLT-1, LDN/OSU 0212320 (LDN) has been previously developed with beneficial outcomes in epileptic animal models but has never been tested as a potential therapeutic for ischemic strokes. The present study evaluated the effects of LDN on stroke-associated brain injury. Male and female mice received LDN or vehicle 24 h before or 2 h after focal ischemia was induced in the sensorimotor cortex. Sensorimotor performance was determined using the Rung Ladder Walk and infarct area was assessed using triphenyltetrazolium chloride staining. Males treated with LDN exhibited upregulated GLT-1 protein levels, significantly smaller infarct size, and displayed better sensorimotor performance in comparison to those treated with vehicle only. In contrast, there was no upregulation of GLT-1 protein levels and no difference in infarct size or sensorimotor performance between vehicle- and LDN-treated females. Taken together, our results indicate that the GLT-1 translational activator LDN improved stroke outcomes in young adult male, but not female mice.

Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra

2014 ◽  
Vol 65 ◽  
pp. 69-81 ◽  
Author(s):  
Maxime Assous ◽  
Laurence Had-Aissouni ◽  
Paolo Gubellini ◽  
Christophe Melon ◽  
Imane Nafia ◽  
...  
Keyword(s):  
Amino Acid ◽  
Substantia Nigra ◽  
Excitatory Amino Acid ◽  
Amino Acid Transporters ◽  
Excitatory Amino Acid Transporters ◽  
Rat Substantia Nigra

scholarly journals Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra

2011 ◽  
Vol 228 (1) ◽  
pp. 41-52 ◽  
Author(s):  
Jason R. Cannon ◽  
Thomas Sew ◽  
Laura Montero ◽  
Edward A. Burton ◽  
J. Timothy Greenamyre
Keyword(s):  
Substantia Nigra ◽  
Lentiviral Transduction ◽  
Rat Substantia Nigra
Sign in / Sign up

Export Citation Format

Share Document