scholarly journals Bmal1‐deficiency affects glial synaptic coverage of the hippocampal mossy fiber synapse and the actin cytoskeleton in astrocytes

Glia ◽  
2019 ◽  
Vol 68 (5) ◽  
pp. 947-962 ◽  
Author(s):  
Amira A. H. Ali ◽  
Beryl Schwarz‐Herzke ◽  
Astrid Rollenhagen ◽  
Max Anstötz ◽  
Martin Holub ◽  
...  
Keyword(s):  
Actin Cytoskeleton ◽  
Mossy Fiber ◽  
Mossy Fiber Synapse

scholarly journals The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
E Anne Martin ◽  
Shruti Muralidhar ◽  
Zhirong Wang ◽  
Diégo Cordero Cervantes ◽  
Raunak Basu ◽  
...  
Keyword(s):  
Synapse Formation ◽  
Mossy Fiber ◽  
Neuron Activity ◽  
Target Cells ◽  
Synaptic Changes ◽  
Mossy Fiber Synapse ◽  
Ca3 Neurons ◽  
Circuit Function ◽  
Feed Forward Inhibition

Synaptic target specificity, whereby neurons make distinct types of synapses with different target cells, is critical for brain function, yet the mechanisms driving it are poorly understood. In this study, we demonstrate Kirrel3 regulates target-specific synapse formation at hippocampal mossy fiber (MF) synapses, which connect dentate granule (DG) neurons to both CA3 and GABAergic neurons. Here, we show Kirrel3 is required for formation of MF filopodia; the structures that give rise to DG-GABA synapses and that regulate feed-forward inhibition of CA3 neurons. Consequently, loss of Kirrel3 robustly increases CA3 neuron activity in developing mice. Alterations in the Kirrel3 gene are repeatedly associated with intellectual disabilities, but the role of Kirrel3 at synapses remained largely unknown. Our findings demonstrate that subtle synaptic changes during development impact circuit function and provide the first insight toward understanding the cellular basis of Kirrel3-dependent neurodevelopmental disorders.

scholarly journals Deconstructing Complexity: Serial Block-Face Electron Microscopic Analysis of the Hippocampal Mossy Fiber Synapse

2013 ◽  
Vol 33 (2) ◽  
pp. 507-522 ◽  
Author(s):  
S. A. Wilke ◽  
J. K. Antonios ◽  
E. A. Bushong ◽  
A. Badkoobehi ◽  
E. Malek ◽  
...  
Keyword(s):  
Mossy Fiber ◽  
Microscopic Analysis ◽  
Electron Microscopic Analysis ◽  
Electron Microscopic ◽  
Block Face ◽  
Mossy Fiber Synapse

scholarly journals Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation

iScience ◽  
2020 ◽  
Vol 23 (4) ◽  
pp. 101025
Author(s):  
Katsunori Kobayashi ◽  
Yasunori Mikahara ◽  
Yuka Murata ◽  
Daiki Morita ◽  
Sumire Matsuura ◽  
...  
Keyword(s):  
Mossy Fiber ◽  
Predominant Role ◽  
Mossy Fiber Synapse

scholarly journals Use-dependent amplification of presynaptic Ca2+ signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse

2008 ◽  
Vol 105 (33) ◽  
pp. 11998-12003 ◽  
Author(s):  
H. Shimizu ◽  
M. Fukaya ◽  
M. Yamasaki ◽  
M. Watanabe ◽  
T. Manabe ◽  
...  
Keyword(s):  
Mossy Fiber ◽  
Ryanodine Receptors ◽  
Mossy Fiber Synapse

scholarly journals Correlated Alterations in Serotonergic and Dopaminergic Modulations at the Hippocampal Mossy Fiber Synapse in Mice Lacking Dysbindin

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e18113 ◽  
Author(s):  
Katsunori Kobayashi ◽  
Satomi Umeda-Yano ◽  
Hidenaga Yamamori ◽  
Masatoshi Takeda ◽  
Hidenori Suzuki ◽  
...  
Keyword(s):  
Mossy Fiber ◽  
Mossy Fiber Synapse

scholarly journals Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
David Vandael ◽  
Yuji Okamoto ◽  
Peter Jonas
Keyword(s):  
Pyramidal Neurons ◽  
Mossy Fiber ◽  
Brain Slices ◽  
High Frequency Stimulation ◽  
Short Term Plasticity ◽  
Glutamate Signaling ◽  
Frequency Stimulation ◽  
Post Tetanic Potentiation ◽  
Mossy Fiber Synapse ◽  
Ca3 Neurons

AbstractThe hippocampal mossy fiber synapse is a key synapse of the trisynaptic circuit. Post-tetanic potentiation (PTP) is the most powerful form of plasticity at this synaptic connection. It is widely believed that mossy fiber PTP is an entirely presynaptic phenomenon, implying that PTP induction is input-specific, and requires neither activity of multiple inputs nor stimulation of postsynaptic neurons. To directly test cooperativity and associativity, we made paired recordings between single mossy fiber terminals and postsynaptic CA3 pyramidal neurons in rat brain slices. By stimulating non-overlapping mossy fiber inputs converging onto single CA3 neurons, we confirm that PTP is input-specific and non-cooperative. Unexpectedly, mossy fiber PTP exhibits anti-associative induction properties. EPSCs show only minimal PTP after combined pre- and postsynaptic high-frequency stimulation with intact postsynaptic Ca2+ signaling, but marked PTP in the absence of postsynaptic spiking and after suppression of postsynaptic Ca2+ signaling (10 mM EGTA). PTP is largely recovered by inhibitors of voltage-gated R- and L-type Ca2+ channels, group II mGluRs, and vacuolar-type H+-ATPase, suggesting the involvement of retrograde vesicular glutamate signaling. Transsynaptic regulation of PTP extends the repertoire of synaptic computations, implementing a brake on mossy fiber detonation and a “smart teacher” function of hippocampal mossy fiber synapses.

Sign in / Sign up

Export Citation Format

Share Document