scholarly journals Plasticity of Myelinating Glia

Glia ◽  
2019 ◽  
Vol 67 (11) ◽  
pp. 2005-2007
Author(s):  
R. Douglas Fields ◽  
William D. Richardson
Keyword(s):  
Myelinating Glia

scholarly journals Autophagy in Myelinating Glia

2019 ◽  
Vol 40 (2) ◽  
pp. 256-266 ◽  
Author(s):  
Jillian Belgrad ◽  
Raffaella De Pace ◽  
R. Douglas Fields
Keyword(s):  
Myelinating Glia

scholarly journals Adenosine: an activity-dependent axonal signal regulating MAP kinase and proliferation in developing Schwann cells

2004 ◽  
Vol 1 (1) ◽  
pp. 23-34 ◽  
Author(s):  
BETH STEVENS ◽  
TOMOKO ISHIBASHI ◽  
JIANG-FAN CHEN ◽  
R. DOUGLAS FIELDS
Keyword(s):  
Schwann Cells ◽  
Adenosine Receptors ◽  
Intracellular Signaling ◽  
Purinergic Receptors ◽  
Purinergic Receptor ◽  
Intracellular Signaling Pathways ◽  
Molecular Approaches ◽  
Myelinating Glia ◽  
Activity Dependent ◽  
Stimulation Of

Nonsynaptic release of ATP from electrically stimulated dorsal root gangion (DRG) axons inhibits Schwann cell (SC) proliferation and arrests SC development at the premyelinating stage, but the specific types of purinergic receptor(s) and intracellular signaling pathways involved in this form of neuron–glia communication are not known. Recent research shows that adenosine is a neuron–glial transmitter between axons and myelinating glia of the CNS. The present study investigates the possibility that adenosine might have a similar function in communicating between axons and premyelinating SCs. Using a combination of pharmacological and molecular approaches, we found that mouse SCs in culture express functional adenosine receptors and ATP receptors, a far more complex array of purinergic receptors than thought previously. Adenosine, but not ATP, activates ERK/MAPK through stimulation of cAMP-linked A2A adenosine receptors. Both ATP and adenosine inhibit proliferation of SCs induced by platelet-derived growth factor (PDGF), via mechanisms that are partly independent. In contrast to ATP, adenosine failed to inhibit the differentiation of SCs to the O4+ stage. This indicates that, in addition to ATP, adenosine is an activity-dependent signaling molecule between axons and premyelinating Schwann cells, but that electrical activity, acting through adenosine, has opposite effects on the differentiation of myelinating glia in the PNS and CNS.

scholarly journals The scales and tales of myelination: using zebrafish and mouse to study myelinating glia

2016 ◽  
Vol 1641 ◽  
pp. 79-91 ◽  
Author(s):  
Sarah D. Ackerman ◽  
Kelly R. Monk
Keyword(s):  
Myelinating Glia

scholarly journals Axons and myelinating glia: An intimate contact

IUBMB Life ◽  
2011 ◽  
pp. n/a-n/a ◽  
Author(s):  
Lida Zoupi ◽  
Maria Savvaki ◽  
Domna Karagogeos
Keyword(s):  
Intimate Contact ◽  
Myelinating Glia

scholarly journals Differential Sox10 genomic occupancy in myelinating glia

Glia ◽  
2015 ◽  
Vol 63 (11) ◽  
pp. 1897-1914 ◽  
Author(s):  
Camila Lopez-Anido ◽  
Guannan Sun ◽  
Matthias Koenning ◽  
Rajini Srinivasan ◽  
Holly A. Hung ◽  
...  
Keyword(s):  
Myelinating Glia

scholarly journals Gap junction communication in myelinating glia

2013 ◽  
Vol 1828 (1) ◽  
pp. 69-78 ◽  
Author(s):  
Anna Nualart-Marti ◽  
Carles Solsona ◽  
R. Douglas Fields
Keyword(s):  
Gap Junction ◽  
Gap Junction Communication ◽  
Myelinating Glia

scholarly journals G Protein-Coupled Receptors in Myelinating Glia

2017 ◽  
Vol 38 (3) ◽  
pp. 316
Author(s):  
Amit Mogha ◽  
Mitchell D’Rozario ◽  
Kelly R. Monk
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Myelinating Glia ◽  
G Protein Coupled
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