Lysophosphatidic acid activates satellite glia cells and Schwann cells

Glia ◽  
2019 ◽  
Vol 67 (5) ◽  
pp. 999-1012 ◽  
Author(s):  
Jan W. Robering ◽  
Lisa Gebhardt ◽  
Katharina Wolf ◽  
Helen Kühn ◽  
Andreas E. Kremer ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Lysophosphatidic Acid ◽  
Glia Cells ◽  
Satellite Glia

scholarly journals Lysophosphatidic Acid Promotes Survival and Differentiation of Rat Schwann Cells

2003 ◽  
Vol 278 (11) ◽  
pp. 9585-9591 ◽  
Author(s):  
Yiwen Li ◽  
Marco I. Gonzalez ◽  
Judy L. Meinkoth ◽  
Jeffrey Field ◽  
Marcelo G. Kazanietz ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Lysophosphatidic Acid

Lysophosphatidic acid activates peripheral glia cells via LPA receptor 1

2018 ◽  
Vol 68 ◽  
pp. S458
Author(s):  
K. Wolf ◽  
L. Gebhardt ◽  
J. Robering ◽  
M. Fischer ◽  
A. Kremer
Keyword(s):  
Lysophosphatidic Acid ◽  
Lpa Receptor ◽  
Glia Cells ◽  
Peripheral Glia

Satellite glia cells in dorsal root ganglia express functional NMDA receptors

Neuroscience ◽  
2013 ◽  
Vol 240 ◽  
pp. 135-146 ◽  
Author(s):  
C. Castillo ◽  
M. Norcini ◽  
L.A. Martin Hernandez ◽  
G. Correa ◽  
T.J.J. Blanck ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Glia Cells ◽  
Satellite Glia

Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration—implications for increased neurofibroma formation during pregnancy

Glia ◽  
2007 ◽  
Vol 55 (5) ◽  
pp. 527-536 ◽  
Author(s):  
Todd D. Nebesio ◽  
Wenyu Ming ◽  
Shi Chen ◽  
Travis Clegg ◽  
Jin Yuan ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Lysophosphatidic Acid ◽  
And Migration

scholarly journals The Ets Domain Transcription Factor Erm Distinguishes Rat Satellite Glia from Schwann Cells and Is Regulated in Satellite Cells by Neuregulin Signaling

2000 ◽  
Vol 219 (1) ◽  
pp. 44-58 ◽  
Author(s):  
Lilian Hagedorn ◽  
Christian Paratore ◽  
Guya Brugnoli ◽  
Jean-Luc Baert ◽  
Nadia Mercader ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Schwann Cells ◽  
Satellite Cells ◽  
Ets Domain ◽  
Satellite Glia

scholarly journals Etv5 is not required for Schwann cell development but is required to regulate the Schwann cell response to peripheral nerve injury

2020 ◽  
Author(s):  
Anjali Balakrishnan ◽  
Lauren Belfiore ◽  
Lakshmy Vasan ◽  
Yacine Touahri ◽  
Morgan Stykel ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Dorsal Root Ganglia ◽  
Peripheral Nerve Injury ◽  
Dorsal Root ◽  
Cell Development ◽  
Wild Type ◽  
Schwann Cell Development ◽  
Satellite Glia

ABSTRACTSchwann cells are the principal glial cells of the peripheral nervous system, and their development into myelinating glia is critically dependent on MEK/ERK signaling. Ets-domain transcription factors (Etv1, Etv4, Etv5) are common downstream effectors of MEK/ERK signalling, but so far, only Etv1 has been ascribed a role in Schwann cell development, and only in non-myelinating cells. Here, we examined the role of Etv5, which is expressed in Schwann cell precursors, including neural crest cells and satellite glia, in Schwann cell lineage development. We analysed Etv5tm1Kmm mutants (designated Etv5−/−) at embryonic days (E) 12.5, E15.5 and E18.5, focusing on dorsal root ganglia. At these embryonic stages, satellite glia (glutamine synthetase) and Schwann cell markers, including transcriptional regulators (Sox10, Sox9, Tfap2a, Pou3f1) and non-transcription factors (Ngfr, BFABP, GFAP), were expressed in the DRG of wild-type and Etv5−/− embryos. Furthermore, by E18.5, quantification of Sox10+ Schwann cells and NeuN+ neurons revealed that these cells were present in normal numbers in the Etv5−/− dorsal root ganglia. We next performed peripheral nerve injuries at postnatal day 21, revealing that Etv5−/− mice had an enhanced injury response, generating more Sox10+ Schwann cells compared to wild-type animals at five days post-injury. Thus, while Etv5 is not required for Schwann cell development, possibly due to genetic redundancy with Etv1 and/or Etv4, Etv5 is an essential negative regulator of the peripheral nerve injury repair response.SIGNIFICANCE STATEMENTOur study sought to determine whether the ets domain transcription factor, Etv5, plays a role in regulating Schwann cell development and nerve repair. By using an embryonically and postnatally viable hypomorphic Etv5 mutant allele, we demonstrated that Etv5 is not required for the development of Schwann cells or other neural crest derivatives in the dorsal root ganglia, including satellite glia and neurons. Surprisingly, loss of Etv5 had a direct impact on the Schwann cell repair response post-injury, resulting in more Schwann cells populating the distal injured nerve site compared to wild-type animals. Thus, this work describes for the first time a role for Etv5 in regulating the Schwann cell repair response after peripheral nerve injury.

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