scholarly journals Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia

Glia ◽  
2018 ◽  
Vol 67 (2) ◽  
pp. 345-359 ◽  
Author(s):  
Jérôme Mairesse ◽  
Manuela Zinni ◽  
Julien Pansiot ◽  
Rahma Hassan-Abdi ◽  
Charlie Demene ◽  
...  
Keyword(s):  
Brain Damage ◽  
Receptor Agonist ◽  
Oxytocin Receptor ◽  
Perinatal Brain Damage

Perinatal brain damage—from pathophysiology to prevention

2003 ◽  
Vol 110 ◽  
pp. S70-S79 ◽  
Author(s):  
Arne Jensen ◽  
Yves Garnier ◽  
Johannes Middelanis ◽  
Richard Berger
Keyword(s):  
Brain Damage ◽  
Perinatal Brain Damage

Abstract WP113: Administration of Direct Angiotensin II Type-2 Receptor Agonist, Compound 21, Even After Stroke Prevents Ischemic Brain Damage

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Masaki Mogi ◽  
Li-Juan Min ◽  
Fei Jing ◽  
Kana Tsukuda ◽  
Kousei Ohshima ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Damage ◽  
Receptor Agonist ◽  
Receptor Stimulation ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Compound 21 ◽  
Deficient Mice

Objectives: Previous our studies showed that angiotensin II type-2 (AT 2 ) receptor stimulation protects neurons after brain ischemic damage using AT 2 receptor-deficient mice. Recently, Compound 21 (C21) is available to use as a direct AT 2 receptor agonist. We reported that administration of C21 induces vascular dilatation via bradykinin-nitric oxide pathway and maintains cerebral blood flow, resulting in prevention of cognitive impairment. These results inspired us the possibility that administration of C21 could protect ischemic brain damage; therefore, we assessed the effect of C21 on stroke expansion by not only pre-treatment, but also a treatment immediately after stroke. Methods: 10 week-old wild-type male C57BL6 mice were subjected to the middle cerebral artery occlusion (MCAO) by electrocoagulation using a subtemporal approach. Ischemic area after stroke was evaluated by time-course analysis by magnetic resonance imaging (MRI) of the brain. C21 was administrated to mice 2 weeks before MCAO or immediately after MCAO treatment by intraperitoneal injection. Cerebral blood flow was evaluated by using 2D-laser speckle blood flow imaging system. Results: No significant remarkable change was observed in blood pressure in mice with or without C21 treatment. Pretreatment of C21 prevented ischemic brain damage 1 day after MCAO. In contrast, such preventive effect by C21 was not observed in AT 2 receptor-deficient mice. On the other hand, C21 treatment immediately after MCAO did not reduce ischemic area 1 day after MCAO, but remarkably reduced this 3 days after MCAO. Treatment with C21 prevented the reduced cerebral blood flow after MCAO. Conclusions: These findings indicate that AT 2 receptor stimulation by C21 prevents ischemic brain damage at least in part via maintaining cerebral blood flow even after stroke. Therefore, administration of C21 could work as a new therapeutical option in patients with stroke even in acute phase.

Inflammatory perinatal brain damage

2005 ◽  
pp. 216-221
Author(s):  
Dorothea Bartels ◽  
Olaf Dammann
Keyword(s):  
Brain Damage ◽  
Perinatal Brain Damage

scholarly journals Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist

1996 ◽  
Vol 302 (1-3) ◽  
pp. 43-48 ◽  
Author(s):  
Dag K.J.E. Von Lubitz ◽  
Mark Beenhakker ◽  
Rick C.-S. Lin ◽  
Margaret F. Carter ◽  
Ian A. Paul ◽  
...  
Keyword(s):  
Brain Damage ◽  
Receptor Agonist ◽  
Memory Deficits ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor

Pathophysiology of perinatal brain damage

1999 ◽  
Vol 30 (2) ◽  
pp. 107-134 ◽  
Author(s):  
Richard Berger ◽  
Yves Garnier
Keyword(s):  
Brain Damage ◽  
Perinatal Brain Damage

Inflammation processes in perinatal brain damage

2010 ◽  
Vol 117 (8) ◽  
pp. 1009-1017 ◽  
Author(s):  
Vincent Degos ◽  
Géraldine Favrais ◽  
Angela M. Kaindl ◽  
Stéphane Peineau ◽  
Anne Marie Guerrot ◽  
...  
Keyword(s):  
Brain Damage ◽  
Perinatal Brain Damage
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