scholarly journals NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer

Glia ◽  
2018 ◽  
Vol 66 (12) ◽  
pp. 2684-2699 ◽  
Author(s):  
Hitoshi Gotoh ◽  
William M. Wood ◽  
Kiran D. Patel ◽  
Daniel C. Factor ◽  
Linda L. Boshans ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Intronic Enhancer ◽  
Bhlh Transcription Factors

scholarly journals 1P123 DMA binding analyses of bHLH transcription factors by FRET measurements(Nucleic acid-binding proteins,Poster Presentations)

2007 ◽  
Vol 47 (supplement) ◽  
pp. S54
Author(s):  
Koji HASEGAWA ◽  
Tatsushi GOTO ◽  
Daisuke KITANO ◽  
Mari KOTOURA ◽  
Fumio TOKUNAGA ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Nucleic Acid ◽  
Binding Proteins ◽  
Nucleic Acid Binding ◽  
Nucleic Acid Binding Proteins ◽  
Poster Presentations ◽  
Bhlh Transcription Factors

scholarly journals The bHLH Transcription Factors MYC2, MYC3, and MYC4 Are Required for Jasmonate-Mediated Inhibition of Flowering in Arabidopsis

2017 ◽  
Vol 10 (11) ◽  
pp. 1461-1464 ◽  
Author(s):  
Houping Wang ◽  
Yang Li ◽  
Jinjing Pan ◽  
Dengji Lou ◽  
Yanru Hu ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Bhlh Transcription Factors

scholarly journals Multiple neural bHLHs ensure the precision of a neuronal specification event in C. elegans

Biology Open ◽  
2021 ◽  
Author(s):  
Konstantina Filippopoulou ◽  
Carole Couillault ◽  
Vincent Bertrand
Keyword(s):  
Transcription Factors ◽  
Quantitative Imaging ◽  
Terminal Differentiation ◽  
Cholinergic Neurons ◽  
Antagonistic Effect ◽  
Specific Class ◽  
C Elegans ◽  
Neuronal Specification ◽  
Bhlh Transcription Factors ◽  
Deleterious Genes

Neural bHLH transcription factors play a key role in the early steps of neuronal specification in many animals. We have previously observed that the Achaete-Scute HLH-3, the Olig HLH-16 and their binding partner the E protein HLH-2 activate the terminal differentiation program of a specific class of cholinergic neurons, AIY, in C. elegans. Here we identify a role for a fourth bHLH, the Neurogenin NGN-1, in this process, raising the question of why so many neural bHLHs are required for a single neuronal specification event. Using quantitative imaging we show that the combined action of different bHLHs is needed to activate the correct level of expression of the terminal selector transcription factors TTX-3 and CEH-10 that subsequently initiate and maintain the expression of a large battery of terminal differentiation genes. Surprisingly, the different bHLHs have an antagonistic effect on another target, the proapoptotic BH3-only factor EGL-1, normally not expressed in AIY and otherwise detrimental for its specification. We propose that the use of multiple neural bHLHs allows robust neuronal specification while, at the same time, preventing spurious activation of deleterious genes.

scholarly journals Atoh8 in Development and Disease

Biology ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 136
Author(s):  
Satya Srirama Karthik Divvela ◽  
Darius Saberi ◽  
Beate Brand-Saberi
Keyword(s):  
Transcription Factors ◽  
Embryonic Development ◽  
Subcellular Location ◽  
Transcriptional Regulators ◽  
Special Group ◽  
Helix Loop Helix ◽  
Wide Range ◽  
Disease Initiation ◽  
Bhlh Transcription Factors ◽  
Bhlh Proteins

Atoh8 belongs to a large superfamily of transcriptional regulators called basic helix-loop-helix (bHLH) proteins. bHLH proteins have been identified in a wide range of organisms from yeast to humans. The members of this special group of transcription factors were found to be involved not only in embryonic development but also in disease initiation and its progression. Given their importance in several fundamental processes, the translation, subcellular location and turnover of bHLH proteins is tightly regulated. Alterations in the expression of bHLH proteins have been associated with multiple diseases also in context with Atoh8 which seems to unfold its functions as both transcriptional activator and repressor. Like many other bHLH transcription factors, so far, Atoh8 has also been observed to be involved in both embryonic development and carcinogenesis where it mainly acts as tumor suppressor. This review summarizes our current understanding of Atoh8 structure, function and regulation and its complex and partially controversial involvement in development and disease.

The rolB gene activates secondary metabolism in Arabidopsis calli via selective activation of genes encoding MYB and bHLH transcription factors

2016 ◽  
Vol 102 ◽  
pp. 70-79 ◽  
Author(s):  
Victor P. Bulgakov ◽  
Galina N. Veremeichik ◽  
Valeria P. Grigorchuk ◽  
Viacheslav G. Rybin ◽  
Yuri N. Shkryl
Keyword(s):  
Transcription Factors ◽  
Secondary Metabolism ◽  
Selective Activation ◽  
Rolb Gene ◽  
Genes Encoding ◽  
Bhlh Transcription Factors
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