Neuregulin-1 positively modulates glial response and improves neurological recovery following traumatic spinal cord injury

Glia ◽  
2017 ◽  
Vol 65 (7) ◽  
pp. 1152-1175 ◽  
Author(s):  
Arsalan Alizadeh ◽  
Scott M. Dyck ◽  
Hardeep Kataria ◽  
Ghazaleh M. Shahriary ◽  
Dung H. Nguyen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Recovery ◽  
Traumatic Spinal Cord Injury ◽  
Neuregulin 1 ◽  
Cord Injury

scholarly journals Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Arsalan Alizadeh ◽  
Kallivalappil T. Santhosh ◽  
Hardeep Kataria ◽  
Abdelilah S. Gounni ◽  
Soheila Karimi-Abdolrezaee
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Immune Response ◽  
Traumatic Spinal Cord Injury ◽  
Neuregulin 1 ◽  
Cord Injury

Neurological Recovery Is Impaired by Concurrent but Not by Asymptomatic Pre-existing Spinal Cord Compression After Traumatic Spinal Cord Injury

Spine ◽  
2012 ◽  
Vol 37 (17) ◽  
pp. 1448-1455 ◽  
Author(s):  
Kensuke Kubota ◽  
Hirokazu Saiwai ◽  
Hiromi Kumamaru ◽  
Kazu Kobayakawa ◽  
Takeshi Maeda ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Neurological Recovery ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury

scholarly journals The relevance of MRI for predicting neurological recovery following cervical traumatic spinal cord injury

Spinal Cord ◽  
2019 ◽  
Vol 57 (10) ◽  
pp. 866-873 ◽  
Author(s):  
Joanie Martineau ◽  
Julien Goulet ◽  
Andréane Richard-Denis ◽  
Jean-Marc Mac-Thiong
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Recovery ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury

scholarly journals P.220 Mechanism of injury is associated with neurological outcomes in cervical sensorimotor complete traumatic spinal cord injury

2021 ◽  
Vol 48 (s3) ◽  
pp. S83-S83
Author(s):  
AB Bak ◽  
A Moghaddamjou ◽  
M Fehlings
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Spinal Injury ◽  
Significant Proportion ◽  
Sports Injury ◽  
Neurological Recovery ◽  
Traumatic Spinal Cord Injury ◽  
Significant Heterogeneity ◽  
Mechanism Of Injury ◽  
Cord Injury

Background: There is significant heterogeneity in neurological recovery after complete (ASIA A) traumatic spinal cord injury (tSCI). Neurological recovery is often associated with a conversion to a higher letter grade of the American Spinal Injury Association’s impairment scale (ASIA). The mechanism of injury (MOI) may play a significant role in the primary injury and should be considered for greater precision in care. Methods: We isolated ASIA A cervical tSCI patients from three multicenter prospective randomized controlled trials (NACTN, STASCIS, Sygen). Chi-square test with pairwise comparisons with Bonferroni corrections was performed to compare the proportion of ASIA A patients that converted to a higher ASIA grade between different MOI. Results: We identified 486 complete cervical tSCI patients. For patients who developed tSCI as a result of a fall, a significant proportion converted to a higher ASIA grade by 52 weeks (p = 0.009). For patients who developed tSCI as a result of a sports injury, a significantly smaller proportion did not convert to a higher ASIA grade compared to those that converted (p = 0.034). Conclusions: Due to the difference in outcomes, tSCI patients should be treated differently depending on their mechanism of injury.

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