Brucella abortus-activated microglia induce neuronal death through primary phagocytosis

Glia ◽  
2017 ◽  
Vol 65 (7) ◽  
pp. 1137-1151 ◽  
Author(s):  
Ana M. Rodríguez ◽  
M. Victoria Delpino ◽  
M. Cruz Miraglia ◽  
Miriam M. Costa Franco ◽  
Paula Barrionuevo ◽  
...  
Keyword(s):  
Brucella Abortus ◽  
Neuronal Death ◽  
Activated Microglia

scholarly journals Reciprocal modulation of C/EBP-α and C/EBP-β by IL-13 in activated microglia prevents neuronal death

2013 ◽  
Vol 43 (11) ◽  
pp. 2854-2865 ◽  
Author(s):  
Hung Chuan Pan ◽  
Cheng Ning Yang ◽  
Yi Wen Hung ◽  
Wen Jane Lee ◽  
Hsing Ru Tien ◽  
...  
Keyword(s):  
Neuronal Death ◽  
Activated Microglia

Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposure

2013 ◽  
Vol 236 ◽  
pp. 270-282 ◽  
Author(s):  
Ya-Nan Zhao ◽  
Fang Wang ◽  
Yan-Xia Fan ◽  
Guan-Fang Ping ◽  
Jing-Yu Yang ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Neuronal Death ◽  
Ethanol Exposure ◽  
Activated Microglia ◽  
Successful Recovery

scholarly journals Mechanisms Underlying Neuronal Death Induced by Chromogranin A-activated Microglia

2000 ◽  
Vol 276 (16) ◽  
pp. 13113-13120 ◽  
Author(s):  
Jaroslava Ciesielski-Treska ◽  
Gabrielle Ulrich ◽  
Sylvette Chasserot-Golaz ◽  
Jean Zwiller ◽  
Marie-Odile Revel ◽  
...  
Keyword(s):  
Neuronal Death ◽  
Chromogranin A ◽  
Activated Microglia

Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis

Glia ◽  
2007 ◽  
Vol 55 (5) ◽  
pp. 483-496 ◽  
Author(s):  
Ayan Ghoshal ◽  
Sulagna Das ◽  
Soumya Ghosh ◽  
Manoj Kumar Mishra ◽  
Vivek Sharma ◽  
...  
Keyword(s):  
Japanese Encephalitis ◽  
Neuronal Death ◽  
Activated Microglia ◽  
Proinflammatory Mediators

scholarly journals Inhibition of Soluble Epoxide Hydrolase after Cardiac Arrest/Cardiopulmonary Resuscitation Induces a Neuroprotective Phenotype in Activated Microglia and Improves Neuronal Survival

2013 ◽  
Vol 33 (10) ◽  
pp. 1574-1581 ◽  
Author(s):  
Jianming Wang ◽  
Tetsuhiro Fujiyoshi ◽  
Yasuharu Kosaka ◽  
Jonathan D Raybuck ◽  
K Matthew Lattal ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Resuscitation ◽  
Neuronal Death ◽  
Epoxide Hydrolase ◽  
Memory Function ◽  
Specific Treatment ◽  
Neuronal Loss ◽  
Soluble Epoxide Hydrolase ◽  
Activated Microglia ◽  
Tnf Α

Cardiac arrest (CA) causes hippocampal neuronal death that frequently leads to severe loss of memory function in survivors. No specific treatment is available to reduce neuronal death and improve functional outcome. The brain's inflammatory response to ischemia can exacerbate injury and provides a potential treatment target. We hypothesized that microglia are activated by CA and contribute to neuronal loss. We used a mouse model to determine whether pharmacologic inhibition of the proinflammatory microglial enzyme soluble epoxide hydrolase (sEH) after CA alters microglial activation and neuronal death. The sEH inhibitor 4-phenylchalcone oxide (4-PCO) was administered after successful cardiopulmonary resuscitation (CPR). The 4-PCO treatment significantly reduced neuronal death and improved memory function after CA/CPR. We found early activation of microglia and increased expression of inflammatory tumor necrosis factor (TNF)-α and interleukin (IL)-1β in the hippocampus after CA/CPR, which was unchanged after 4-PCO treatment, while expression of antiinflammatory IL-10 increased significantly. We conclude that sEH inhibition after CA/CPR can alter the transcription profile in activated microglia to selectively induce antiinflammatory and neuroprotective IL-10 and reduce subsequent neuronal death. Switching microglial gene expression toward a neuroprotective phenotype is a promising new therapeutic approach for ischemic brain injury.

Epicatechin improves proprioception without preventing neuronal death in the 6-hydroxydopamine’s Parkinsonism model.

2016 ◽  
Vol 9 (2) ◽  
pp. 282-291
Author(s):  
Letícia Ribeiro ◽  
Cristiane Batassini ◽  
Roberta Bristot Silvestrin ◽  
Lisiane Bizarro ◽  
Tadeu Mello e Souza ◽  
...  
Keyword(s):  
Neuronal Death
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