Diabetic Schwann cells suffer from nerve growth factor and neurotrophin-3 underproduction and poor associability with axons

Glia ◽  
2013 ◽  
Vol 61 (12) ◽  
pp. 1990-1999 ◽  
Author(s):  
Indranil Dey ◽  
Nisha Midha ◽  
Geeta Singh ◽  
Amanda Forsyth ◽  
Sarah K. Walsh ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Schwann Cells ◽  
Nerve Growth ◽  
Neurotrophin 3

Neurotrophin-3-induced production of nerve growth factor is suppressed in Schwann cells exposed to high glucose: involvement of the polyol pathway

2004 ◽  
Vol 91 (6) ◽  
pp. 1430-1438 ◽  
Author(s):  
Takeshi Suzuki ◽  
Hiromi Sekido ◽  
Noriaki Kato ◽  
Yukiharu Nakayama ◽  
Chihiro Yabe-Nishimura
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Schwann Cells ◽  
High Glucose ◽  
Polyol Pathway ◽  
Nerve Growth ◽  
Neurotrophin 3

Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 levels in human amniotic fluid

1999 ◽  
Vol 181 (5) ◽  
pp. 1225-1230 ◽  
Author(s):  
Christine E. Marx ◽  
Brandon J. Vance ◽  
L.Fredrik Jarskog ◽  
Nancy C. Chescheir ◽  
John H. Gilmore
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Amniotic Fluid ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Human Amniotic Fluid ◽  
Nerve Growth ◽  
Neurotrophin 3

trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues

Development ◽  
1993 ◽  
Vol 118 (2) ◽  
pp. 463-475 ◽  
Author(s):  
L. Tessarollo ◽  
P. Tsoulfas ◽  
D. Martin-Zanca ◽  
D.J. Gilbert ◽  
N.A. Jenkins ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Tyrosine Kinases ◽  
Expression Patterns ◽  
Developmental Expression ◽  
Receptor System ◽  
Nerve Growth ◽  
Trk Receptor ◽  
Neurotrophin 3 ◽  
Neuronal Tissues

The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related neurotrophins. Here we present a developmental expression study of trkC, which encodes a receptor for neurotrophin-3 (NT-3). Like the related genes, trk and trkB, trkC is expressed primarily in neural lineages although the pattern is complex and includes non-neuronal cells. Direct comparison with trk and trkB developmental expression patterns permits the following observations. (1) trkC is expressed in novel neural tissues where other Trk genes are silent. (2) Some tissues appear to coexpress trkB and trkC receptors in the embryo and in the adult. (3) trkC expression can be detected in the gastrulating embryo. These data provide insights into the role of Trk-family receptors and nerve growth factor-related neurotrophins during development and suggest that, in addition to regulating neuronal survival and differentiation, the neurotrophin/Trk receptor system may have broader physiological effects. Finally, interspecific mouse backcrosses have been used to map the location of each of the Trk genes on mouse chromosomes. Alignment with available chromosomal maps identify possible linkage between the Trk genes and known neurological mutations.

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