NFATc3 promotes Ca2+-dependent MMP3 expression in astroglial cells

Glia ◽  
2013 ◽  
Vol 61 (7) ◽  
pp. 1052-1066 ◽  
Author(s):  
Fernando Neria ◽  
María del Carmen Serrano-Perez ◽  
Patricia Velasco ◽  
Katia Urso ◽  
Pedro Tranque ◽  
...  
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Author(s):  
J.N. Turner ◽  
W.G. Shain ◽  
V. Madelian ◽  
R.A. Grassucci ◽  
D.L. Forman

Homogeneous cultures of astroglial cells have proved useful for studying biochemical, pharmacological, and toxicological responses of astrocytes to effectors of central nervous system function. LRM 55 astroglial cells, which were derived from a rat glioma and maintained in continuous culture, exhibit a number of astrocyte properties (1-3). Stimulation of LRM 55s and astrocytes in primary cell cultures with the beta-adrenergic agonist isoproterenol results in rapid changes of morphology. Studies with time lapse video light microscopy (VLM) and high-voltage electron microscopy (HVEM) have been correlated to changes in intracellular levels of c-AMP. This report emphasizes the HVEM results.


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Dieter Leibfritz ◽  
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Ralf Dringen
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Vol 373 (3) ◽  
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Valeria Visalli ◽  
Carmen Colica ◽  
Robert Nisticò ◽  
Ernesto Palma ◽  
...  

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