A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination

Glia ◽  
2013 ◽  
Vol 61 (5) ◽  
pp. 732-749 ◽  
Author(s):  
Cui Li ◽  
Lin Xiao ◽  
Xiuyun Liu ◽  
Wenjing Yang ◽  
Weiran Shen ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Functional Role ◽  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Oligodendrocyte Precursor

scholarly journals The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke

2017 ◽  
Vol 8 (6) ◽  
pp. e2871-e2871 ◽  
Author(s):  
Elisabetta Bonfanti ◽  
Paolo Gelosa ◽  
Marta Fumagalli ◽  
Leda Dimou ◽  
Francesca Viganò ◽  
...  
Keyword(s):  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Oligodendrocyte Precursor

scholarly journals Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia

2019 ◽  
Vol 8 (9) ◽  
Author(s):  
Natsue Kishida ◽  
Takakuni Maki ◽  
Yasushi Takagi ◽  
Ken Yasuda ◽  
Hisanori Kinoshita ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Oligodendrocyte Precursor

scholarly journals TNFR2 Signaling Regulates the Immunomodulatory Function of Oligodendrocyte Precursor Cells

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1785
Author(s):  
Haritha L. Desu ◽  
Placido Illiano ◽  
James S. Choi ◽  
Maureen C. Ascona ◽  
Han Gao ◽  
...  
Keyword(s):  
Demyelinating Disease ◽  
Cell Interaction ◽  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Proliferation And Differentiation ◽  
Progressive Neurodegeneration ◽  
Cytokine Tumor Necrosis Factor ◽  
Oligodendrocyte Precursor ◽  
Necrosis Factor

Multiple sclerosis (MS) is a neuroimmune disorder characterized by inflammation, CNS demyelination, and progressive neurodegeneration. Chronic MS patients exhibit impaired remyelination capacity, partly due to the changes that oligodendrocyte precursor cells (OPCs) undergo in response to the MS lesion environment. The cytokine tumor necrosis factor (TNF) is present in the MS-affected CNS and has been implicated in disease pathophysiology. Of the two active forms of TNF, transmembrane (tmTNF) and soluble (solTNF), tmTNF signals via TNFR2 mediating protective and reparative effects, including remyelination, whereas solTNF signals predominantly via TNFR1 promoting neurotoxicity. To better understand the mechanisms underlying repair failure in MS, we investigated the cellular responses of OPCs to inflammatory exposure and the specific role of TNFR2 signaling in their modulation. Following treatment of cultured OPCs with IFNγ, IL1β, and TNF, we observed, by RNA sequencing, marked inflammatory and immune activation of OPCs, accompanied by metabolic changes and dysregulation of their proliferation and differentiation programming. We also established the high likelihood of cell–cell interaction between OPCs and microglia in neuroinflammatory conditions, with OPCs able to produce chemokines that can recruit and activate microglia. Importantly, we showed that these functions are exacerbated when TNFR2 is ablated. Together, our data indicate that neuroinflammation leads OPCs to shift towards an immunomodulatory phenotype while diminishing their capacity to proliferate and differentiate, thus impairing their repair function. Furthermore, we demonstrated that TNFR2 plays a key role in this process, suggesting that boosting TNFR2 activation or its downstream signals could be an effective strategy to restore OPC reparative capacity in demyelinating disease.

scholarly journals The role of the prostaglandin E2 receptors in vulnerability of oligodendrocyte precursor cells to death

2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Noel G. Carlson ◽  
Satya Bellamkonda ◽  
Linda Schmidt ◽  
Jonathan Redd ◽  
Thomas Huecksteadt ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Oligodendrocyte Precursor

scholarly journals The role of nuclear receptors in the differentiation of oligodendrocyte precursor cells derived from fetal and adult neural stem cells

2019 ◽  
Vol 37 ◽  
pp. 101443 ◽  
Author(s):  
Vito Antonio Baldassarro ◽  
Wojciech Krężel ◽  
Mercedes Fernández ◽  
Brigitte Schuhbaur ◽  
Luciana Giardino ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Nuclear Receptors ◽  
Precursor Cells ◽  
Oligodendrocyte Precursor Cells ◽  
Adult Neural Stem Cells ◽  
Oligodendrocyte Precursor
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