Pathological adaptive responses of Schwann cells to endoplasmic reticulum stress in bortezomib-induced peripheral neuropathy

Glia ◽  
2010 ◽  
Vol 58 (16) ◽  
pp. 1961-1976 ◽  
Author(s):  
Yoon Kyung Shin ◽  
So Young Jang ◽  
Hyun Kyoung Lee ◽  
Junyang Jung ◽  
Duk Joon Suh ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Peripheral Neuropathy ◽  
Endoplasmic Reticulum Stress ◽  
Schwann Cells ◽  
Adaptive Responses

scholarly journals Tang-Luo-Ning, a Traditional Chinese Medicine, Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis of Schwann Cells under High Glucose Environment

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Weijie Yao ◽  
Xinwei Yang ◽  
Jiayue Zhu ◽  
Biane Gao ◽  
Renhui Liu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Peripheral Neuropathy ◽  
Chinese Medicine ◽  
Endoplasmic Reticulum Stress ◽  
Er Stress ◽  
Schwann Cells ◽  
Marker Protein ◽  
Definite Effect ◽  
Induced Apoptosis ◽  
Apoptosis Marker

Tang-Luo-Ning (TLN) has a definite effect in the clinical treatment of diabetic peripheral neuropathy (DPN). Schwann cells (SCs) apoptosis induced by endoplasmic reticulum stress (ER stress) is one of the main pathogeneses of DPN. This study investigates whether TLN can inhibit SCs apoptosis by inhibiting ER stress-induced apoptosis. Our previous researches have demonstrated that TLN could increase the expression of ER stress marker protein GRP78 and inhibited the expression of apoptosis marker protein CHOP in ER stress. In this study, the results showed that TLN attenuated apoptosis by decreasing Ca2+ level in SCs and maintaining ER morphology. TLN could decrease downstream proteins of CHOP including GADD34 and Ero1α, while it increased P-eIF2α and decreased the upstream proteins of CHOP including P-IRE1α/IRE1α and XBP-1, thereby reducing ER stress-induced apoptosis.

scholarly journals CHOP/ORP150 Ratio in Endoplasmic Reticulum Stress: A New Mechanism for Diabetic Peripheral Neuropathy

2013 ◽  
Vol 32 (2) ◽  
pp. 367-379 ◽  
Author(s):  
Yuan-Bo Wu ◽  
Hong-Qi Li ◽  
Ming-Shan Ren ◽  
Wen-Ting Li ◽  
Xin-Yi Lv ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Peripheral Neuropathy ◽  
Endoplasmic Reticulum Stress ◽  
Diabetic Peripheral Neuropathy

Endoplasmic reticulum stress contributes to prediabetic peripheral neuropathy

2013 ◽  
Vol 247 ◽  
pp. 342-348 ◽  
Author(s):  
Sergey Lupachyk ◽  
Pierre Watcho ◽  
Alexander A. Obrosov ◽  
Roman Stavniichuk ◽  
Irina G. Obrosova
Keyword(s):  
Endoplasmic Reticulum ◽  
Peripheral Neuropathy ◽  
Endoplasmic Reticulum Stress

scholarly journals Glycolaldehyde induces endoplasmic reticulum stress and apoptosis in Schwann cells

2015 ◽  
Vol 2 ◽  
pp. 1454-1462 ◽  
Author(s):  
Keisuke Sato ◽  
Ryosuke Tatsunami ◽  
Kaori Yama ◽  
Yu Murao ◽  
Yoshiko Tampo
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Schwann Cells
Sign in / Sign up

Export Citation Format

Share Document