Monocyte chemoattractant protein-1 (MCP-1) produced via NF-κB signaling pathway mediates migration of amoeboid microglia in the periventricular white matter in hypoxic neonatal rats

Glia ◽  
2009 ◽  
Vol 57 (6) ◽  
pp. 604-621 ◽  
Author(s):  
Y. Y. Deng ◽  
J. Lu ◽  
E. A. Ling ◽  
C. Kaur
Keyword(s):  
White Matter ◽  
Signaling Pathway ◽  
Periventricular White Matter ◽  
Neonatal Rats ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Amoeboid Microglia

scholarly journals Microarray analysis of gene expression in mouse aorta reveals role of the calcium signaling pathway in control of atherosclerosis susceptibility

2009 ◽  
Vol 296 (5) ◽  
pp. H1336-H1343 ◽  
Author(s):  
Zuobiao Yuan ◽  
Toru Miyoshi ◽  
Yongde Bao ◽  
Jason P. Sheehan ◽  
Alan H. Matsumoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Calcium Signaling ◽  
Signaling Pathway ◽  
Oxidized Ldl ◽  
Atherosclerotic Lesion ◽  
Differentially Expressed ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Calcium Signaling Pathway

Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit a marked difference in atherosclerotic lesion formation when deficient in apolipoprotein E (apoE−/−), and the arterial wall has been identified as a source of the difference in atherosclerosis susceptibility. In the present study, differences in gene expression in aortic walls of the two strains were analyzed by microarrays. Total RNA was extracted from the aorta of 6-wk-old female B6 and C3H apoE−/− mice fed a chow or Western diet. There were 1,514 genes in chow fed mice and 590 genes in Western fed mice that were found to be differentially expressed between the two strains. Pathway analysis of differentially expressed genes suggested a role for the calcium signaling pathway in regulating atherosclerosis susceptibility. Oxidized LDL (oxLDL) induced a dose-dependent rise in cytosolic calcium levels in B6 endothelial cells. oxLDL-induced monocyte chemoattractant protein-1 production was inhibited by pretreatment with calcium chelator EGTA or intracellular calcium trapping compound BAPTA, indicating that calcium ions mediate the effect of oxLDL on monocyte chemoattractant protein-1 induction. The present findings demonstrate involvement of the calcium signaling pathway in the inflammatory process of atherogenesis.

Monocyte Chemoattractant Protein (MCP)-1 in Rotavirus-Associated White Matter Injury in Newborns

2019 ◽  
Vol 50 (04) ◽  
pp. 228-234
Author(s):  
Jung Sook Yeom ◽  
Jae-Young Jo ◽  
Ji Sook Park ◽  
Young-Soo Kim ◽  
Ju-Young Chung ◽  
...  
Keyword(s):  
White Matter ◽  
Underlying Mechanism ◽  
Interferon Γ ◽  
White Matter Injury ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Il Interleukin ◽  
Factor Α ◽  
And Control

AbstractRecent reports have suggested an association between rotavirus infection and a distinctive pattern of white matter injury (WMI) in neonates with seizures; however, the connection between the two is not fully understood. To evaluate the underlying mechanism, we profiled and compared eight cytokines (IL [interleukin]-1β, IL-6, IL-8, IL-10, IFN-γ [interferon-γ ], MCP-1 [monocyte chemoattractant protein-1], MIP-1β [macrophage inflammatory protein-1β], and TNF-α [tumor necrosis factor-α]) in the cerebrospinal fluid (CSF) of 33 neonates with seizures who had no other well-known causes of seizures and 13 control patients (rotavirus-induced gastroenteritis but without seizures). Among the 33 neonates with seizures, 9 showed WMI and all were infected with rotavirus (R + W + ). Among the 24 patients without WMI, 11 were infected with rotavirus (R + W − ) and 13 were not (R − W − ).Only MCP-1 and MIP-1β were different between the groups. MCP-1 was increased in R+ W+ compared with R + W− (p < 0.01), R − W− (p < 0.01), and control (p = 0.03) patients. MIP-1β was decreased in R + W+ compared with R − W− (p < 0.01) and control (p < 0.01), but not R + W− (p = 0.23) patients. MCP-1 and MIP-1β are C-C chemokines that recruit immune cells to the site of inflammation. Our pilot study suggests MCP-1-mediated monocyte recruitment may be linked with this complication caused by rotavirus.

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