Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells

Glia ◽  
2007 ◽  
Vol 55 (16) ◽  
pp. 1656-1667 ◽  
Author(s):  
C. G. Jung ◽  
H. J. Kim ◽  
V. E. Miron ◽  
S. Cook ◽  
T. E. Kennedy ◽  
...  
Keyword(s):  
Receptor Modulation ◽  
Functional Consequences ◽  
S1p Receptor

scholarly journals Nanofiber-Based Delivery of Bioactive Lipids Promotes Pro-regenerative Inflammation and Enhances Muscle Fiber Growth After Volumetric Muscle Loss

2021 ◽  
Vol 9 ◽  
Author(s):  
Cheryl L. San Emeterio ◽  
Lauren A. Hymel ◽  
Thomas C. Turner ◽  
Molly E. Ogle ◽  
Emily G. Pendleton ◽  
...  
Keyword(s):  
Muscle Loss ◽  
Muscle Injuries ◽  
Bioactive Lipids ◽  
Muscle Stem Cells ◽  
Receptor Modulation ◽  
Volumetric Muscle Loss ◽  
Signaling Axis ◽  
Repair Mechanisms ◽  
Sphingosine 1 Phosphate ◽  
S1p Receptor

Volumetric muscle loss (VML) injuries after extremity trauma results in an important clinical challenge often associated with impaired healing, significant fibrosis, and long-term pain and functional deficits. While acute muscle injuries typically display a remarkable capacity for regeneration, critically sized VML defects present a dysregulated immune microenvironment which overwhelms innate repair mechanisms leading to chronic inflammation and pro-fibrotic signaling. In this series of studies, we developed an immunomodulatory biomaterial therapy to locally modulate the sphingosine-1-phosphate (S1P) signaling axis and resolve the persistent pro-inflammatory injury niche plaguing a critically sized VML defect. Multiparameter pseudo-temporal 2D projections of single cell cytometry data revealed subtle distinctions in the altered dynamics of specific immune subpopulations infiltrating the defect that were critical to muscle regeneration. We show that S1P receptor modulation via nanofiber delivery of Fingolimod (FTY720) was characterized by increased numbers of pro-regenerative immune subsets and coincided with an enriched pool of muscle stem cells (MuSCs) within the injured tissue. This FTY720-induced priming of the local injury milieu resulted in increased myofiber diameter and alignment across the defect space followed by enhanced revascularization and reinnervation of the injured muscle. These findings indicate that localized modulation of S1P receptor signaling via nanofiber scaffolds, which resemble the native extracellular matrix ablated upon injury, provides great potential as an immunotherapy for bolstering endogenous mechanisms of regeneration following VML injury.

Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation

Neurology ◽  
2011 ◽  
Vol 76 (Issue 8, Supplement 3) ◽  
pp. S3-S8 ◽  
Author(s):  
T. Hla ◽  
V. Brinkmann
Keyword(s):  
Receptor Modulation ◽  
Sphingosine 1 Phosphate ◽  
S1p Receptor

scholarly journals A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
T. Bobinger ◽  
T. Bäuerle ◽  
L. Seyler ◽  
S. v Horsten ◽  
S. Schwab ◽  
...  
Keyword(s):  
Brain Injury ◽  
Acute Stage ◽  
Secondary Brain Injury ◽  
Protective Effects ◽  
Receptor Modulator ◽  
Receptor Modulation ◽  
Short Term Study ◽  
Sphingosine 1 Phosphate ◽  
S1p Receptor ◽  
The Brain

Background. Stroke activates the immune system and induces brain infiltration by immune cells, aggravating brain injury. Poststroke immunomodulation via (S1P-)receptor modulation is beneficial; however, the S1P-modulator in clinical use (FTY-720) is unspecific, and undesirable side effects have been reported. Previously, we tested effects of a novel selective S1P-receptor modulator, Siponimod, on ICH-induced brain injury in acute stage of the disease. In the current study, we investigated whether protective effects of Siponimod, evaluated in a short-term study, will protect the brain of ICH animals at long term as well. Methods. 134 C57BL/6N mice were divided into sham and ICH-operated groups. Collagenase model of ICH was employed. ICH animals were divided into Siponimod treated and nontreated. Dose- and time-dependent effects of Siponimod were investigated. Contraplay between development of brain injury and the number of lymphocytes infiltrating the brain was investigated by forelimb placing, T-Maze test, brain water content calculation, MRI scanning, and immunostaining. Results. Depending on the therapeutic strategy, Siponimod attenuated the development of brain edema, decreased ICH-induced ventriculomegaly and improved neurological functions of animals after ICH. It was associated with less lymphocytes in the brain of ICH animals. Conclusion. Siponimod is able to decrease the brain injury and improves neurological functions of animals after ICH.

Toll-like Receptor Modulation in Head and Neck Cancer

2008 ◽  
Vol 28 (3) ◽  
pp. 201-213 ◽  
Author(s):  
Ralph Pries ◽  
Sandra Wulff ◽  
Barbara Wollenberg
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Toll Like Receptor ◽  
Receptor Modulation
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