Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes

Glia ◽  
2006 ◽  
Vol 55 (3) ◽  
pp. 274-281 ◽  
Author(s):  
Y. V. Kucheryavykh ◽  
L. Y. Kucheryavykh ◽  
C. G. Nichols ◽  
H. M. Maldonado ◽  
K. Baksi ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Glutamate Uptake ◽  
Cortical Astrocytes ◽  
Inward Rectifying Potassium Channel

scholarly journals A Weakly Inward Rectifying Potassium Channel of the Salmon Brain

1996 ◽  
Vol 271 (26) ◽  
pp. 15729-15735 ◽  
Author(s):  
Yoshihiro Kubo ◽  
Tomoyuki Miyashita ◽  
Kaoru Kubokawa
Keyword(s):  
Potassium Channel ◽  
Weakly Inward ◽  
Inward Rectifying Potassium Channel

scholarly journals Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

1994 ◽  
Vol 14 (5) ◽  
pp. 2924-2932 ◽  
Author(s):  
A Volterra ◽  
D Trotti ◽  
C Tromba ◽  
S Floridi ◽  
G Racagni
Keyword(s):  
Free Radicals ◽  
Oxygen Free Radicals ◽  
Glutamate Uptake ◽  
Uptake Inhibition ◽  
Cortical Astrocytes

scholarly journals Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice

Epilepsia ◽  
2010 ◽  
Vol 51 (9) ◽  
pp. 1707-1713 ◽  
Author(s):  
Mikhail Inyushin ◽  
Lilia Y. Kucheryavykh ◽  
Yuriy V. Kucheryavykh ◽  
Colin G. Nichols ◽  
Russell J. Buono ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Glutamate Uptake ◽  
Channel Activity ◽  
Potassium Channel Activity

The predisposition to thyrotoxic periodic paralysis (TPP) is due to a genetic variant in the inward-rectifying potassium channel,KCNJ2

2013 ◽  
Vol 80 (5) ◽  
pp. 770-771 ◽  
Author(s):  
Xingyan Wang ◽  
Chun Chung Chow ◽  
Xiaoqiang Yao ◽  
Gary T. C. Ko ◽  
Clive S. Cockram ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Genetic Variant ◽  
Periodic Paralysis ◽  
Thyrotoxic Periodic Paralysis ◽  
Inward Rectifying Potassium Channel

Lack of confirmation of anti-inward rectifying potassium channel 4.1 antibodies as reliable markers of multiple sclerosis

2014 ◽  
Vol 20 (13) ◽  
pp. 1699-1703 ◽  
Author(s):  
Elodie Nerrant ◽  
Céline Salsac ◽  
Mahmoud Charif ◽  
Xavier Ayrignac ◽  
Clarisse Carra-Dalliere ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Potassium Channel ◽  
Immunosorbent Assay ◽  
Neurological Diseases ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Lower Prevalence ◽  
Immunofluorescence Analysis ◽  
Specific Staining ◽  
Inward Rectifying Potassium Channel

Background: auto-antibodies against the potassium channel inward rectifying potassium channel 4.1 (Kir4.1) have previously been identified in 46% of patients with multiple sclerosis (MS). Objectives: to confirm these findings. Methods: we evaluated the presence of anti-Kir4.1 antibodies by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence in 268 MS patients, 46 patients with other neurological diseases (OND) and 45 healthy controls. Results: anti-Kir4.1 antibodies were found in 7.5% of MS patients, 4.3% of OND patients and 4.4% of healthy controls. Immunofluorescence analysis did not identify any specific staining. Conclusions: we confirmed the presence of anti-Kir4.1 antibodies in MS patients, but at a much lower prevalence than previously reported.

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