Laser microdissection reveals regional and cellular differences in GFAP mRNA upregulation following brain injury, axonal denervation, and amyloid plaque deposition

Glia ◽  
2004 ◽  
Vol 48 (1) ◽  
pp. 76-84 ◽  
Author(s):  
Guido J. Burbach ◽  
Doris Dehn ◽  
Domenico Del Turco ◽  
Matthias Staufenbiel ◽  
Thomas Deller
Keyword(s):  
Brain Injury ◽  
Laser Microdissection ◽  
Amyloid Plaque ◽  
Plaque Deposition

scholarly journals α-1-Antichymotrypsin Promotes β-Sheet Amyloid Plaque Deposition in a Transgenic Mouse Model of Alzheimer's Disease

2001 ◽  
Vol 21 (5) ◽  
pp. 1444-1451 ◽  
Author(s):  
Lars N. G. Nilsson ◽  
Kelly R. Bales ◽  
Giovanni DiCarlo ◽  
Marcia N. Gordon ◽  
Dave Morgan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Amyloid Plaque ◽  
Transgenic Mouse Model ◽  
Plaque Deposition ◽  
Model Of Alzheimer’S Disease ◽  
Β Sheet

Targeted Intraparenchymal Delivery of Human NGF by Gene Transfer to the Primate Basal Forebrain for 3 Months Does Not Accelerate β-Amyloid Plaque Deposition

1998 ◽  
Vol 154 (2) ◽  
pp. 573-582 ◽  
Author(s):  
Mark H. Tuszynski ◽  
David E. Smith ◽  
Jeffrey Roberts ◽  
Heather McKay ◽  
Elliott Mufson
Keyword(s):  
Gene Transfer ◽  
Basal Forebrain ◽  
Amyloid Plaque ◽  
Plaque Deposition ◽  
Β Amyloid

Abstract WP397: Longitudinal Sex Differences in Cerebral Amyloid Angiopathy

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Michael Maniskas ◽  
Jacob Hudobenko ◽  
Akhiko Urayama ◽  
Louise McCullough ◽  
Bharti Manwani
Keyword(s):  
Mouse Model ◽  
Cerebral Amyloid Angiopathy ◽  
Cognitive Deficits ◽  
Elderly Women ◽  
Amyloid Plaque ◽  
Amyloid Angiopathy ◽  
Female Mice ◽  
Plaque Deposition ◽  
Significant Difference ◽  
Cerebral Amyloid

Background: Cerebral amyloid angiopathy (CAA) is the most common cause of lobar intracerebral hemorrhage in the aging population. It is mostly a consequence of amyloid beta40 (Aβ40) deposition within the cerebral blood vessels. A recent study has shown that this amyloid plaque deposition is more prevalent in the brain of elderly women compared to men. The increase in amyloid plaque deposition is linked to increased cerebral microbleeds (CMBs) and reduced cognition. The major objective of this study to discern if a sexual dichotomy existed in CMBs and cognition using mouse model of CAA. Methods: We used the Tg-SwDI mouse (“CAA mouse”, harboring Swedish, Dutch, and Iowa mutations of human amyloid precursor protein) model that develops Aβ deposits and cognitive deficits at 3-4 months. Cognitive deficits were analyzed using Fear Conditioning (FC) in pre-symptomatic (3 month) and (12 month) old male and female mice. Briefly, mice were acclimated to the FC chamber for a 2 minute training trial to record baseline. After 1 hour rest, mice were placed back in the chamber for 2 minutes, where they received a 2 millisecond shock (1,000 u/amp). Day 2, activity was recorded for 3 minutes and this measure was compared to baseline to determine Mean Inactive State (MIS-seconds). Mice were euthanized following FC, and brains scanned ex vivo using a MRI T2 Star sequence to assess for CMBs. Results: FC showed a significant difference in MIS (p<0.05) between male (3 and 12 months old) and female (3 months only) mice, n=6/group, suggesting that aged females had significantly lower MIS (Figure 1). MRI showed that aged female mice had more CMBs compared to aged male mice (females, 15.3±7 vs. males 0.25 ±0.2, n= 3/group, p=0.05. Conclusion: In a mouse model of CAA, our results demonstrate that aged females have increased CMBs as compared to males, which may be contributing to decreased cognition as seen on FC. Ongoing studies are designed to further understand the etiology of this sex difference.

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

2018 ◽  
Vol 69 ◽  
pp. 351-363 ◽  
Author(s):  
Zhenri Ou ◽  
Xuejian Kong ◽  
Xiangdong Sun ◽  
Xiaosong He ◽  
Le Zhang ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Amyloid Plaque ◽  
Metformin Treatment ◽  
Plaque Deposition

P1-064: Human APP overexpression in a transgenic rat model leads to intracellular Aβ accumulation and amyloid plaque deposition

2008 ◽  
Vol 4 ◽  
pp. T224-T225
Author(s):  
Fabio Canneva ◽  
Wanda Leon ◽  
Vanessa Partridge ◽  
Adriana Ducatenzeiler ◽  
Leena Alhonen ◽  
...  
Keyword(s):  
Rat Model ◽  
Amyloid Plaque ◽  
Transgenic Rat ◽  
Plaque Deposition ◽  
Transgenic Rat Model

scholarly journals Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition

2002 ◽  
Vol 81 (3) ◽  
pp. 441-448 ◽  
Author(s):  
Lisa R. Fodero ◽  
Javier Sáez-Valero ◽  
Catriona A. McLean ◽  
Ralph N. Martins ◽  
Konrad Beyreuther ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Plaque ◽  
Plaque Deposition ◽  
Altered Glycosylation
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