Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors

Glia ◽  
2003 ◽  
Vol 43 (3) ◽  
pp. 218-230 ◽  
Author(s):  
Marta Fumagalli ◽  
Roberta Brambilla ◽  
Nadia D'Ambrosi ◽  
Cinzia Volonté ◽  
Michela Matteoli ◽  
...  
Keyword(s):  
Calcium Signaling ◽  
P2y Receptors ◽  
P2x And P2y Receptors ◽  
Cortical Astrocytes

Role of P2X and P2Y receptors in rat myocardial contractility during ontogeny

2007 ◽  
Vol 143 (6) ◽  
pp. 695-698 ◽  
Author(s):  
T. A. Anikina ◽  
G. A. Bilalova ◽  
A. A. Zverev ◽  
F. G. Sitdikov
Keyword(s):  
Myocardial Contractility ◽  
P2y Receptors ◽  
P2x And P2y Receptors

scholarly journals Pathophysiological Role of Extracellular Purinergic Mediators in the Control of Intestinal Inflammation

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Yosuke Kurashima ◽  
Hiroshi Kiyono ◽  
Jun Kunisawa
Keyword(s):  
Immune Cells ◽  
Purinergic Receptors ◽  
Intestinal Inflammation ◽  
P2y Receptors ◽  
P2x And P2y Receptors ◽  
Extracellular Compartment ◽  
Pathophysiological Role ◽  
Novel Targets ◽  
Irritable Bowel

Purinergic mediators such as adenosine 5′-triphosphate (ATP) are released into the extracellular compartment from damaged tissues and activated immune cells. They are then recognized by multiple purinergic P2X and P2Y receptors. Release and recognition of extracellular ATP are associated with both the development and the resolution of inflammation and infection. Accumulating evidence has recently suggested the potential of purinergic receptors as novel targets for drugs for treating intestinal disorders, including intestinal inflammation and irritable bowel syndrome. In this review, we highlight recent findings regarding the pathophysiological role of purinergic mediators in the development of intestinal inflammation.

Role of network connectivity in intercellular calcium signaling

2008 ◽  
Vol 237 (6) ◽  
pp. 745-754 ◽  
Author(s):  
I.V. Dokukina ◽  
M.E. Gracheva ◽  
E.A. Grachev ◽  
J.D. Gunton
Keyword(s):  
Calcium Signaling ◽  
Network Connectivity

scholarly journals Role of Nucleotide P2 Receptors in Calcium Signaling and Prolactin Release in Pituitary Lactotrophs

2003 ◽  
Vol 278 (47) ◽  
pp. 46270-46277 ◽  
Author(s):  
Mu-Lan He ◽  
Arturo E. Gonzalez-Iglesias ◽  
Stanko S. Stojilkovic
Keyword(s):  
Calcium Signaling ◽  
P2 Receptors ◽  
Prolactin Release

scholarly journals Calcium Signaling in Vertebrate Development and Its Role in Disease

2018 ◽  
Vol 19 (11) ◽  
pp. 3390 ◽  
Author(s):  
Sudip Paudel ◽  
Regan Sindelar ◽  
Margaret Saha
Keyword(s):  
Calcium Signaling ◽  
Critical Role ◽  
Molecular Techniques ◽  
Model Organisms ◽  
Vertebrate Development ◽  
Developmental Defects ◽  
Calcium Activity ◽  
Human Genes ◽  
Underlying Mechanisms

Accumulating evidence over the past three decades suggests that altered calcium signaling during development may be a major driving force for adult pathophysiological events. Well over a hundred human genes encode proteins that are specifically dedicated to calcium homeostasis and calcium signaling, and the majority of these are expressed during embryonic development. Recent advances in molecular techniques have identified impaired calcium signaling during development due to either mutations or dysregulation of these proteins. This impaired signaling has been implicated in various human diseases ranging from cardiac malformations to epilepsy. Although the molecular basis of these and other diseases have been well studied in adult systems, the potential developmental origins of such diseases are less well characterized. In this review, we will discuss the recent evidence that examines different patterns of calcium activity during early development, as well as potential medical conditions associated with its dysregulation. Studies performed using various model organisms, including zebrafish, Xenopus, and mouse, have underscored the critical role of calcium activity in infertility, abortive pregnancy, developmental defects, and a range of diseases which manifest later in life. Understanding the underlying mechanisms by which calcium regulates these diverse developmental processes remains a challenge; however, this knowledge will potentially enable calcium signaling to be used as a therapeutic target in regenerative and personalized medicine.

scholarly journals Expression and a role of functionally coupled P2Y receptors in human dendritic cells

FEBS Letters ◽  
1999 ◽  
Vol 445 (2-3) ◽  
pp. 402-408 ◽  
Author(s):  
Q.H. Liu ◽  
H. Bohlen ◽  
S. Titzer ◽  
O. Christensen ◽  
V. Diehl ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
P2y Receptors ◽  
Human Dendritic Cells
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