Active Src expression is induced after rat peripheral nerve injury

Glia ◽  
2003 ◽  
Vol 42 (2) ◽  
pp. 184-193 ◽  
Author(s):  
Ying-Luan Zhao ◽  
Kiyoshi Takagawa ◽  
Takeshi Oya ◽  
Hong-Fa Yang ◽  
Zhi-Yang Gao ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Rat Peripheral Nerve

Two-component collagen nerve guides support axonal regeneration in the rat peripheral nerve injury model

2016 ◽  
Vol 11 (12) ◽  
pp. 3349-3361 ◽  
Author(s):  
S.G.A. van Neerven ◽  
K. Haastert-Talini ◽  
A. Boecker ◽  
T. Schriever ◽  
C. Dabhi ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Axonal Regeneration ◽  
Nerve Guides ◽  
Injury Model ◽  
Two Component ◽  
Rat Peripheral Nerve

Alternative RNA splicing associated with axon regeneration after rat peripheral nerve injury

2018 ◽  
Vol 308 ◽  
pp. 80-89 ◽  
Author(s):  
Susu Mao ◽  
Shanshan Zhang ◽  
Zhenyu Zhou ◽  
Xiangxiang Shi ◽  
Tao Huang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Rna Splicing ◽  
Axon Regeneration ◽  
Rat Peripheral Nerve

Transplantation Strategies for Spinal Cord Injury Based on Microenvironment Modulation

2020 ◽  
Vol 15 (6) ◽  
pp. 522-530
Author(s):  
Jiawei Shu ◽  
Feng Cheng ◽  
Zhe Gong ◽  
Liwei Ying ◽  
Chenggui Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Autonomic Dysfunction ◽  
Peripheral Nerve Injury ◽  
Therapeutic Effects ◽  
Permanent Damage ◽  
Cord Injury ◽  
Severe Motor

Spinal cord injury (SCI) is different from peripheral nerve injury; it results in devastating and permanent damage to the spine, leading to severe motor, sensory and autonomic dysfunction. SCI produces a complex microenvironment that can result in hemorrhage, inflammation and scar formation. Not only does it significantly limit regeneration, but it also challenges a multitude of transplantation strategies. In order to promote regeneration, researchers have recently begun to focus their attention on strategies that manipulate the complicated microenvironment produced by SCI. And some have achieved great therapeutic effects. Hence, reconstructing an appropriate microenvironment after transplantation could be a potential therapeutic solution for SCI. In this review, first, we aim to summarize the influential compositions of the microenvironment and their different effects on regeneration. Second, we highlight recent research that used various transplantation strategies to modulate different microenvironments produced by SCI in order to improve regeneration. Finally, we discuss future transplantation strategies regarding SCI.

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