Effects of prolactin on intracellular calcium concentration and cell proliferation in human glioma cells

Glia ◽  
2002 ◽  
Vol 38 (3) ◽  
pp. 200-214 ◽  
Author(s):  
Thomas Ducret ◽  
Sihem Boudina ◽  
Bruno Sorin ◽  
Anne Marie Vacher ◽  
Isabelle Gourdou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Intracellular Calcium ◽  
Calcium Concentration ◽  
Glioma Cells ◽  
Intracellular Calcium Concentration ◽  
Human Glioma ◽  
Human Glioma Cells

scholarly journals Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells

2003 ◽  
Vol 84 (6) ◽  
pp. 1288-1295 ◽  
Author(s):  
Mara D'Onofrio ◽  
Antonietta Arcella ◽  
Valeria Bruno ◽  
Richard T. Ngomba ◽  
Giuseppe Battaglia ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Metabotropic Glutamate ◽  
Pharmacological Blockade

scholarly journals Caffeine inhibits cell proliferation and regulates PKA/GSK3β pathways in U87MG human glioma cells

2010 ◽  
Vol 31 (3) ◽  
pp. 275-279 ◽  
Author(s):  
Bo Mi Ku ◽  
Yeon Kyung Lee ◽  
Joo Yeon Jeong ◽  
Jinhyun Ryu ◽  
Jungil Choi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells

scholarly journals Silencing myelin protein zero-like 1 expression suppresses cell proliferation and invasiveness of human glioma cells by inhibiting multiple cancer-associated signal pathways

2021 ◽  
Vol 9 (4) ◽  
pp. 229-244
Author(s):  
Simiao Zhang ◽  
Sandian Zhang ◽  
Hongzhen Wang ◽  
Xuege Huang ◽  
Jinzhi Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Lines ◽  
Colony Formation ◽  
Glioma Cells ◽  
Myelin Protein ◽  
Human Glioma ◽  
Myelin Protein Zero ◽  
Human Glioma Cells ◽  
Protein Zero

Glioma is the most common primary malignant tumor of the adult central nervous system. It has high morbidity and poor survival. Myelin protein zero-like protein 1 (MPZL1) is a cell surface glycoprotein that activates numerous adhesion-dependent signaling pathways. MPZL1 plays important roles in human cancers that include metastatic process; however, it is not clear if MPZL1 plays a role in human glioma. Therefore, this study aimed to determine if silencing MPZL1 impacted the cell proliferative features of human glioma cells. First, MPZL1 expression was investigated in human glioma samples and tumor cell lines. Then the effects of small interfering RNA (siRNA)-targeting MPZL1 were analyzed on proliferation, colony formation, cell cycle progression, and invasion of human glioma cells. The results from this study demonstrated that MPZL1 was highly expressed in human glioma tissues and glioma cell lines. In addition, knockdown of MPZL1 significantly inhibited cell proliferation, colony formation, and invasiveness of glioma cells, and effectively induced cell cycle arrest at the G1 phase. Western blotting analysis indicated that silencing MPZL1 expression downregulated the expression of matrix metalloproteinase-2 (MMP-2), WNT1, caspase-3, cyclin A1, epidermal growth factor receptor (EGFR), and signal transducer and activator of transcription 3 (STAT3), and upregulated p53. The results from this study suggest that MPZL1 might be a marker for tumors and could be a potential therapeutic target for human glioma.

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