scholarly journals Loss of Power in Two-Stage Residual-Outcome Regression Analysis in Genetic Association Studies

2012 ◽  
pp. n/a-n/a ◽  
Author(s):  
Ronglin Che ◽  
Alison A. Motsinger-Reif ◽  
Chad C. Brown
Keyword(s):  
Regression Analysis ◽  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Two Stage

scholarly journals Robust joint analysis allowing for model uncertainty in two-stage genetic association studies

2011 ◽  
Vol 12 (1) ◽  
pp. 9 ◽  
Author(s):  
Dongdong Pan ◽  
Qizhai Li ◽  
Ningning Jiang ◽  
Aiyi Liu ◽  
Kai Yu
Keyword(s):  
Genetic Association ◽  
Model Uncertainty ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Joint Analysis ◽  
Two Stage

scholarly journals Evidence for a two-stage model of dependence using the NESARC and its implications for genetic association studies

2008 ◽  
Vol 92 (1-3) ◽  
pp. 258-266 ◽  
Author(s):  
Gary A. Heiman ◽  
Elizabeth Ogburn ◽  
Prakash Gorroochurn ◽  
Katherine M. Keyes ◽  
Deborah Hasin
Keyword(s):  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Stage Model ◽  
Two Stage

scholarly journals A fully adjusted two-stage procedure for rank-normalization in genetic association studies

2019 ◽  
Vol 43 (3) ◽  
pp. 263-275 ◽  
Author(s):  
Tamar Sofer ◽  
Xiuwen Zheng ◽  
Stephanie M. Gogarten ◽  
Cecelia A. Laurie ◽  
Kelsey Grinde ◽  
...  
Keyword(s):  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Two Stage

scholarly journals Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kevin K. Esoh ◽  
Tobias O. Apinjoh ◽  
Steven G. Nyanjom ◽  
Ambroise Wonkam ◽  
Emile R. Chimusa ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Ethnic Groups ◽  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Genomic Region ◽  
Sub Saharan Africa ◽  
Genome Wide Association Studies ◽  
Fine Scale ◽  
Sub Saharan

AbstractInferences from genetic association studies rely largely on the definition and description of the underlying populations that highlight their genetic similarities and differences. The clustering of human populations into subgroups (population structure) can significantly confound disease associations. This study investigated the fine-scale genetic structure within Cameroon that may underlie disparities observed with Cameroonian ethnicities in malaria genome-wide association studies in sub-Saharan Africa. Genotype data of 1073 individuals from three regions and three ethnic groups in Cameroon were analyzed using measures of genetic proximity to ascertain fine-scale genetic structure. Model-based clustering revealed distinct ancestral proportions among the Bantu, Semi-Bantu and Foulbe ethnic groups, while haplotype-based coancestry estimation revealed possible longstanding and ongoing sympatric differentiation among individuals of the Foulbe ethnic group, and their Bantu and Semi-Bantu counterparts. A genome scan found strong selection signatures in the HLA gene region, confirming longstanding knowledge of natural selection on this genomic region in African populations following immense disease pressure. Signatures of selection were also observed in the HBB gene cluster, a genomic region known to be under strong balancing selection in sub-Saharan Africa due to its co-evolution with malaria. This study further supports the role of evolution in shaping genomes of Cameroonian populations and reveals fine-scale hierarchical structure among and within Cameroonian ethnicities that may impact genetic association studies in the country.

scholarly journals Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap project

2007 ◽  
Vol 16 (20) ◽  
pp. 2494-2505 ◽  
Author(s):  
Yasuhito Nannya ◽  
Kenjiro Taura ◽  
Mineo Kurokawa ◽  
Shigeru Chiba ◽  
Seishi Ogawa
Keyword(s):  
Genetic Association ◽  
Empirical Data ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Hapmap Project ◽  
Genome Wide
Sign in / Sign up

Export Citation Format

Share Document