Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis

2006 ◽  
Vol 30 (5) ◽  
pp. 409-422 ◽  
Author(s):  
Silke Schmidt ◽  
Michael A. Schmidt ◽  
Xuejun Qin ◽  
Eden R. Martin ◽  
Elizabeth R. Hauser
Keyword(s):  
Linkage Analysis ◽  
Interaction Model ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Subset Analysis ◽  
Gene Environment ◽  
And Performance

A Gene–Environment Interaction Model of Stress-Induced Hypertension

2005 ◽  
Vol 5 (2) ◽  
pp. 109-132 ◽  
Author(s):  
Ikhide G. Imumorin ◽  
Yanbin Dong ◽  
Haidong Zhu ◽  
Joseph C. Poole ◽  
Gregory A. Harshfield ◽  
...  
Keyword(s):  
Interaction Model ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Induced Hypertension

Epigenetics and ADHD: Toward an Integrative Approach of the Disorder Pathogenesis

2017 ◽  
Vol 23 (7) ◽  
pp. 655-664 ◽  
Author(s):  
Meriem Hamza ◽  
Soumeyya Halayem ◽  
Soumaya Bourgou ◽  
Mona Daoud ◽  
Fatma Charfi ◽  
...  
Keyword(s):  
Stressful Life Events ◽  
Interaction Model ◽  
Specific Pattern ◽  
Current Data ◽  
Integrative Approach ◽  
Environment Interaction ◽  
Clinical Genetic ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Vasoactive Intestinal Peptide Receptor

Objective: Epigenetic hypothesis is one of the research pathways used to explain the complex etiology of neurodevelopmental disorders. This review highlights the findings of recent studies in the field of epigenetics in ADHD. Methods: An electronic literature search using Medline. Results: In the Gene × Environment interaction model, several clinical, genetic and molecular arguments support the epigenetic hypothesis in ADHD etiology. Environmental ADHD risk factors including toxic, nutritional factors and stressful life events lead to changes in DNA methylation and in histone modification levels. One critical CpG site located in the promoter of the DRD4 gene exhibited a specific pattern in ADHD children. A methylome wide exploration of DNA showed decreased methylation in vasoactive intestinal peptide receptor 2 gene, which was not replicated by further research. Conclusion: Current data require consolidation and could lead to the identification of biomarkers and the introduction of new modalities of treatment.

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