Contribution of thermolabile methylenetetrahydrofolate reductase variant to total plasma homocysteine levels in healthy men and women. Inter99 (2)

2003 ◽  
Vol 24 (4) ◽  
pp. 322-330 ◽  
Author(s):  
Lise Lotte N. Husemoen ◽  
Troels F. Thomsen ◽  
Mogens Fenger ◽  
Henrik L. Jørgensen ◽  
Torben Jørgensen
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Plasma Homocysteine ◽  
Total Plasma ◽  
Men And Women ◽  
Healthy Men

scholarly journals Low Dose Betaine Supplementation Leads to Immediate and Long Term Lowering of Plasma Homocysteine in Healthy Men and Women

2003 ◽  
Vol 133 (12) ◽  
pp. 4135-4138 ◽  
Author(s):  
Margreet R. Olthof ◽  
Trinette van Vliet ◽  
Esther Boelsma ◽  
Petra Verhoef
Keyword(s):  
Low Dose ◽  
Plasma Homocysteine ◽  
Men And Women ◽  
Healthy Men ◽  
Betaine Supplementation

scholarly journals Betaine Supplementation Lowers Plasma Homocysteine in Healthy Men and Women

2003 ◽  
Vol 133 (5) ◽  
pp. 1291-1295 ◽  
Author(s):  
Gery R. Steenge ◽  
Petra Verhoef ◽  
Martijn B. Katan
Keyword(s):  
Plasma Homocysteine ◽  
Men And Women ◽  
Healthy Men ◽  
Betaine Supplementation

scholarly journals Prevalence of hyperhomocysteinaemia and its major determinants in rural Chinese hypertensive patients aged 45–75 years

2012 ◽  
Vol 109 (7) ◽  
pp. 1284-1293 ◽  
Author(s):  
Yu Wang ◽  
Xiaoying Li ◽  
Xianhui Qin ◽  
Yefeng Cai ◽  
Mingli He ◽  
...  
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Geometric Mean ◽  
Folic Acid Supplementation ◽  
Plasma Homocysteine ◽  
Activity Levels ◽  
Total Plasma ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
High Prevalence ◽  
Grade 3

We aimed to investigate the prevalence of hyperhomocysteinaemia (total plasma homocysteine (tHcy) ≥ 10 μmol/l) and its major determinants in rural Chinese hypertensive patients. A cross-sectional investigation was carried out in Lianyungang of Jiangsu province, China. This analysis included 13 946 hypertensive adults. The prevalence of hyperhomocysteinaemia was 51·6 % (42·7 % in women and 65·6 % in men). The OR of hyperhomocysteinaemia were 1·52 (95 % CI 1·39, 1·67) and 2·32 (95 % CI 2·07, 2·61) for participants aged 55–65 and 65–75 v. 45–55 years; 1·27 (95 % CI 1·18, 1·37) for participants with a BMI ≥ 25 v. < 25 kg/m2; 1·14 (95 % CI 1·06, 1·23) for participants with v. without antihypertensive treatment; 1·09 (95 % CI 1·00, 1·18) for residents inland v. coastal; 0·89 (95 % CI 0·82, 0·97) and 0·83 (95 % CI 0·74, 0·92) for participants with moderate and high v. low physical activity levels; 1·54 (95 % CI 1·41, 1·68) and 2·47 (95 % CI 2·17, 2·81) for participants with a glomerular filtration rate 60–90 and < 60 v. ≥ 90 ml/min per 1·73 m2; and 1·20 (95 % CI 1·07, 1·35) and 3·81 (95 % CI 3·33, 4·36) for participants with CT and TT v. CC genotype at methylenetetrahydrofolate reductase 677C>T polymorphism, respectively. Furthermore, higher tHcy concentrations were observed in smokers of both sexes (men: geometric mean 12·1 (interquartile range (IQR) 9·2–14·5) v. 11·9 (IQR 9·3–14·0) μmol/l, P= 0·005; women: geometric mean 10·3 (IQR 8·3–13·0) v. 9·6 (IQR 7·8–11·6) μmol/l, P= 0·010), and only in males with hypertension grade 3 (v. grade 1 or controlled blood pressure) (geometric mean 12·1 (IQR 9·2–14·4) v. 11·7 (IQR 9·2–14·0), P= 0·016) and in male non-drinkers (yes v. no) (geometric mean 12·3 (IQR 9·4–14·8) v. 11·7 (IQR 9·1–13·9), P= 0·014). In conclusion, there was a high prevalence of hyperhomocysteinaemia in Chinese hypertensive adults, particularly in the inlanders, who may benefit greatly from tHcy-lowering strategies, such as folic acid supplementation and lifestyle change.

scholarly journals The index of insulin resistance (FIRI) is not associated with plasma homocysteine levels in young, non-obese healthy men and women

2011 ◽  
Vol 3 ◽  
Author(s):  
Anna Czajkowska ◽  
Grażyna Lutosławska ◽  
Krzysztof Mazurek ◽  
Jadwiga Ambroszkiewicz ◽  
Piotr Żmijewski
Keyword(s):  
Insulin Resistance ◽  
Plasma Homocysteine ◽  
Men And Women ◽  
Healthy Men

Effects of Mixed Dietary Supplements on Total Plasma Homocysteine Concentrations (tHcy): A Randomized, Double-Blind, Placebo-Controlled Trial

2012 ◽  
Vol 82 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Salah E. Gariballa ◽  
Sarah J. Forster ◽  
Hilary J. Powers
Keyword(s):  
Older Patients ◽  
Controlled Trial ◽  
Plasma Homocysteine ◽  
Acute Illness ◽  
Vitamin B ◽  
Total Plasma ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Nutrient Supplement ◽  
Plasma Thcy

Background: Although a number of studies have reported raised total plasma homocysteine (tHcy) concentrations in free-living older people, there are no data on homocysteine response to a mixed nutrient supplement in older patients. A raised plasma homocysteine concentration in older patients is partly a reflection of their co-morbidity, including impaired renal function, and there is uncertainty about the extent to which dietary interventions can improve plasma tHcy. Aim: To determine the plasma tHcy response to dietary supplements during acute illness. Methods: Two-hundred and thirty-six hospitalized, acutely ill older patients, who were part of a randomized double-blind placebo-controlled trial, were assigned to receive a daily oral nutritional supplement drink containing 1.3 mg of vitamin B2, 1.4 mg of vitamin B6, 1.5 μg of B12, 200 μg of folic acid, or a placebo, for 6 weeks. Outcome measures were plasma tHcy concentration at baseline, 6 weeks, and 6 months. Results: The mean plasma tHcy concentration fell among patients given the supplements (mean difference 4.1 µmol/L [95 % C.I, 0.14 to 8.03), p = 0.043], but tHcy concentration increased between 6 weeks and 6 months, after patients stopped taking the supplements [mean difference -2.0 µmol/L (95 % C.I, -03.9 to -0.18), p = 0.033]. About 46 % of patients in the placebo group and 55 % of patients in the supplement group had hyperhomocysteinemia (>14 µmol/L) at baseline compared with 45 % and 29 % at the end of the treatment period. Conclusions: A mixed nutrient supplement containing physiological amounts of B vitamins significantly reduced plasma tHcy concentrations in older patients recovering from acute illness.

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