Consanguinity and the transmission/disequilibrium test for allelic association

2001 ◽  
Vol 21 (1) ◽  
pp. 68-77 ◽  
Author(s):  
S. Bennett ◽  
R.N. Curnow
Keyword(s):  
Transmission Disequilibrium Test ◽  
Allelic Association ◽  
Transmission Disequilibrium

scholarly journals Rare-Variant Extensions of the Transmission Disequilibrium Test: Application to Autism Exome Sequence Data

2014 ◽  
Vol 94 (1) ◽  
pp. 33-46 ◽  
Author(s):  
Zongxiao He ◽  
Brian J. O’Roak ◽  
Joshua D. Smith ◽  
Gao Wang ◽  
Stanley Hooker ◽  
...  
Keyword(s):  
Rare Variant ◽  
Transmission Disequilibrium Test ◽  
Sequence Data ◽  
Transmission Disequilibrium ◽  
Exome Sequence Data ◽  
Test Application ◽  
Exome Sequence

An entropy-based genome-wide transmission/disequilibrium test

2007 ◽  
Vol 121 (3-4) ◽  
pp. 357-367 ◽  
Author(s):  
Jinying Zhao ◽  
Eric Boerwinkle ◽  
Momiao Xiong
Keyword(s):  
Transmission Disequilibrium Test ◽  
Transmission Disequilibrium ◽  
Genome Wide

The 3p21.1-p21.3 Hereditary Vascular Retinopathy Locus Increases the Risk for Raynaud's Phenomenon and Migraine

Cephalalgia ◽  
2005 ◽  
Vol 25 (12) ◽  
pp. 1168-1172 ◽  
Author(s):  
JJ Hottenga ◽  
KRJ Vanmolkot ◽  
EE Kors ◽  
S Kheradmand Kia ◽  
PTVM de Jong ◽  
...  
Keyword(s):  
Transmission Disequilibrium Test ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Child Transmission ◽  
Transmission Disequilibrium ◽  
Susceptibility Factor ◽  
Dutch Family ◽  
Parent Child

Previously, we described a large Dutch family with hereditary vascular retinopathy (HVR), Raynaud's phenomenon and migraine. A locus for HVR was mapped on chromosome 3p21.1-p21.3, but the gene has not yet been identified. The fact that all three disorders share a vascular aetiology prompted us to study whether the HVR haplotype also contributed to Raynaud's phenomenon and migraine in this family. Whereas the parent-child transmission disequilibrium test (TDT) did not reach significance, the sibling TDT revealed that the HVR haplotype harbours a susceptibility factor for Raynaud's phenomenon and migraine. Identification of the HVR gene will improve the understanding of the pathophysiology of HVR, Raynaud's phenomenon and migraine.

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