scholarly journals Targeting and conditional inactivation of the murineMen1 locus using the Cre recombinase:loxP System

genesis ◽  
2002 ◽  
Vol 32 (2) ◽  
pp. 150-151 ◽  
Author(s):  
Christine Biondi ◽  
Michael Gartside ◽  
Ian Tonks ◽  
Carol Paterson ◽  
Nicholas K. Hayward ◽  
...  
Keyword(s):  
Conditional Inactivation

Derivation of a mouse model for conditional inactivation ofPax9

genesis ◽  
2007 ◽  
Vol 45 (7) ◽  
pp. 460-464 ◽  
Author(s):  
Ralf Kist ◽  
Elizabeth Greally ◽  
Heiko Peters
Keyword(s):  
Mouse Model ◽  
Conditional Inactivation

scholarly journals Cystic Renal Neoplasia Following Conditional Inactivation of Apc in Mouse Renal Tubular Epithelium

2004 ◽  
Vol 280 (5) ◽  
pp. 3938-3945 ◽  
Author(s):  
Chao-Nan Qian ◽  
Jared Knol ◽  
Peter Igarashi ◽  
Fangming Lin ◽  
Uko Zylstra ◽  
...  
Keyword(s):  
Tubular Epithelium ◽  
Renal Tubular Epithelium ◽  
Conditional Inactivation ◽  
Renal Tubular ◽  
Renal Neoplasia

scholarly journals Impaired Hair Follicle Morphogenesis and Polarized Keratinocyte Movement upon Conditional Inactivation of Integrin-linked Kinase in the Epidermis

2008 ◽  
Vol 19 (4) ◽  
pp. 1462-1473 ◽  
Author(s):  
Kerry-Ann Nakrieko ◽  
Ian Welch ◽  
Holly Dupuis ◽  
Dawn Bryce ◽  
Agnieszka Pajak ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Developmental Stages ◽  
Single Cells ◽  
Forward Movement ◽  
Keratinocyte Proliferation ◽  
Cultured Keratinocytes ◽  
Conditional Inactivation ◽  
Integrin Linked Kinase ◽  
Key Aspects

Integrin-linked kinase (ILK) is key for cell survival, migration, and adhesion, but little is known about its role in epidermal development and homeostasis in vivo. We generated mice with conditional inactivation of the Ilk gene in squamous epithelia. These mice die perinatally and exhibit skin blistering and severe defects in hair follicle morphogenesis, including greatly reduced follicle numbers, failure to progress beyond very early developmental stages, and pronounced defects in follicular keratinocyte proliferation. ILK-deficient epidermis shows abnormalities in adhesion to the basement membrane and in differentiation. ILK-deficient cultured keratinocytes fail to attach and spread efficiently and exhibit multiple abnormalities in actin cytoskeletal organization. Ilk gene inactivation in cultured keratinocytes causes impaired ability to form stable lamellipodia, to directionally migrate, and to polarize. These defects are accompanied by abnormal distribution of active Cdc42 to cell protrusions, as well as reduced activation of Rac1 upon induction of cell migration in scraped keratinocyte monolayers. Significantly, alterations in cell spreading and forward movement in single cells can be rescued by expression of constitutively active Rac1 or RhoG. Our studies underscore a central and distinct role for ILK in hair follicle development and in polarized cell movements, two key aspects of epithelial morphogenesis and function.

scholarly journals Conditional inactivation of the peroxisome biogenesisPex13 gene by Cre-loxP excision

genesis ◽  
2002 ◽  
Vol 32 (2) ◽  
pp. 179-180 ◽  
Author(s):  
Jonas Bjorkman ◽  
Ian Tonks ◽  
Megan A. Maxwell ◽  
Carol Paterson ◽  
Graham F. Kay ◽  
...  
Keyword(s):  
Conditional Inactivation

scholarly journals Conditional inactivation of Npy1r gene in mice induces behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram

2018 ◽  
Vol 133 ◽  
pp. 12-22 ◽  
Author(s):  
Angela Longo ◽  
Melissa Fadda ◽  
Claudio Brasso ◽  
Paolo Mele ◽  
Paola Palanza ◽  
...  
Keyword(s):  
Orbitofrontal Cortex ◽  
Conditional Inactivation

scholarly journals Conditional Inactivation of TACE by a Sox9 Promoter Leads to Osteoporosis and Increased Granulopoiesis via Dysregulation of IL-17 and G-CSF

2009 ◽  
Vol 182 (4) ◽  
pp. 2093-2101 ◽  
Author(s):  
Keisuke Horiuchi ◽  
Tokuhiro Kimura ◽  
Takeshi Miyamoto ◽  
Kana Miyamoto ◽  
Haruhiko Akiyama ◽  
...  
Keyword(s):  
Conditional Inactivation

Conditional inactivation of the Csk gene during T cell development

1997 ◽  
Vol 56 ◽  
pp. 350
Author(s):  
C. Schmedt ◽  
T. Niidome ◽  
K. Rajewsky ◽  
S. Aizawa ◽  
A. Tarakhovsky
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Conditional Inactivation
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