scholarly journals Supporting Scientific Advice through a Boundary Organization

2018 ◽  
Vol 2 (9) ◽  
pp. 1800018 ◽  
Author(s):  
Eric B. Kennedy
Keyword(s):  
Scientific Advice ◽  
Boundary Organization

Science, Politics, and the Pandemic

2020 ◽  
Vol 119 (820) ◽  
pp. 303-309
Author(s):  
J. Nicholas Ziegler
Keyword(s):  
United States ◽  
Biomedical Research ◽  
Scale Up ◽  
Political Leadership ◽  
The United States ◽  
Scientific Advice ◽  
The United Kingdom ◽  
Effective Policy ◽  
Scientific Expertise ◽  
The Uk

Comparing the virus responses in Germany, the United Kingdom, and the United States shows that in order for scientific expertise to result in effective policy, rational political leadership is required. Each of these three countries is known for advanced biomedical research, yet their experiences in the COVID-19 pandemic diverged widely. Germany’s political leadership carefully followed scientific advice and organized public–private partnerships to scale up testing, resulting in relatively low infection levels. The UK and US political responses were far more erratic and less informed by scientific advice—and proved much less effective.

scholarly journals A Decade of Marketing Authorization Applications of Anticancer Drugs in the European Union: An Analysis of Procedural Timelines

2021 ◽  
Author(s):  
Marjolein Garsen ◽  
Maaike Steenhof ◽  
Alex Zwiers
Keyword(s):  
Anticancer Drugs ◽  
Marketing Authorization ◽  
European Medicines Agency ◽  
Company Size ◽  
Scientific Advice ◽  
The European Union ◽  
Small Companies ◽  
Procedure Time ◽  
Total Procedure Time ◽  
Total Procedure

Abstract Background Cancer is a serious global health problem and a major cause of death. The European Medicines Agency (EMA) has established several regulatory initiatives to expedite the development and authorization of drugs to ensure timely access of patients. In this study, we analyzed the procedural timelines of marketing authorization applications for anticancer drugs in the EU, with a specific focus to special regulatory programs, scientific advice and company size. Methods Anticancer drugs that received an opinion from the EMA between January 2010 and December 2019 were included in the study. Public assessment reports were used to obtain publicly available information of the drugs. Results We identified 96 applications for new anticancer drugs. 34 applications were granted access to at least one expedited program offered by the EMA. Total procedure time was reduced from average 370 to 200–215 days when accelerated assessment was granted. Granting of a conditional marketing authorization or an orphan designation, as well as having scientific advice, only mildly affected total procedure time. Average total procedure time of small companies was much longer compared with medium-sized and large companies (483 versus 356 days), which was caused by an increased clock stop time. Conclusion Total procedure time for anticancer is mainly affected by the granting of accelerated assessment, which reduced the total procedure time, and company size, where total procedure time is much longer for small companies. Small companies are advised to have, and especially adhere to scientific advice to reduce procedure time and increase the chance of success.

Correlating Helmet System Mass Properties with Pain Levels towards Helicopter Aircrew Neck-trouble Mitigating Solutions

2018 ◽  
Vol 62 (1) ◽  
pp. 67-70
Author(s):  
Philip S. E. Farrell ◽  
Elaine Maceda ◽  
Ahmed Niri
Keyword(s):  
Neck Pain ◽  
Air Force ◽  
Chronic Neck Pain ◽  
Scientific Advice ◽  
Prevalence Rates ◽  
Pain Level ◽  
Mass Properties ◽  
System Assessment ◽  
Royal Canadian Air Force

Royal Canadian Air Force aircrew members have reported neck-trouble prevalence rates of 75%. To address this problem, a four-year project was recently completed that proposed, developed, assessed, and provided scientific advice on neck pain solutions. One of the solutions involved a Helmet System Assessment trial where helmet system mass properties and pain levels were collected from thirty-nine helicopter aircrew. These data were used to determine a relationship between head supported mass properties and pain level. The results show that experienced aircrew with chronic neck trouble have learned to manage their pain by reducing the amount of counter weights during night sorties, while novice aircrew wear counterweights that they are issued, which is often more than needed. Thus, a possible mitigating solution is to wear minimal counter weights so to delay the onset of episodic or chronic neck pain.

Scientific advice seen from the perspective of a minister of science

1993 ◽  
Vol 1 (1) ◽  
pp. 3-9
Author(s):  
Heinz Riesenhuber
Keyword(s):  
Final Outcome ◽  
Scientific Advice ◽  
Funding Policy ◽  
Science Funding ◽  
Wide Range ◽  
The Way

Thea purpose of science funding policy is to pave the way into new territory without knowing the final outcome to be expected. This needs the input of a wide range of scientific advice in response to well defined questions. There must be a serious intention to listen and if possible act on such advice.

Scientific Advice for Federal Regulation

1991 ◽  
Vol 69 (18) ◽  
pp. 57
Author(s):  
WILLIAM A. BLANPIED
Keyword(s):  
Scientific Advice ◽  
Federal Regulation

scholarly journals Encourage governments to heed scientific advice

Nature ◽  
2016 ◽  
Vol 537 (7622) ◽  
pp. 587-587 ◽  
Author(s):  
Bill Colglazier
Keyword(s):  
Scientific Advice
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