Structural organization ofMYCN amplicons of neuroblastoma tumors, xenografts, and cell lines characterized by the sequences encompassing theMYCN amplicons in a human neuroblastoma cell line

1993 ◽  
Vol 8 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Kiyotaka Akiyama ◽  
Naotoshi Kanda ◽  
Masao Yamada ◽  
Mieko Kato ◽  
Keiko Tadokoro ◽  
...  
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Structural Organization ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Human Neuroblastoma Cell Line

scholarly journals Esomeprazole and pantoprazole enhance the antiproliferative effects of cisplatin on the human neuroblastoma SH-SY5Y cell line

2019 ◽  
Vol 7 (3) ◽  
pp. 734
Author(s):  
Mustafa Karademir ◽  
Merve Ergül
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Gastric Ulcers ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Human Neuroblastoma Cell Line ◽  
Antiproliferative Effects ◽  
Anti Cancer

Background: Proton pump inhibitors (PPIs) largely used a drug to treat gastroesophageal disease such as gastric ulcers. Moreover, in recent years, several studies suggest that PPIs have an important anti-cancer effect in monotherapy and or combination with chemotherapy. The aim of this study was to investigate whether esomeprazole and pantoprazole exhibit anti-cancer effect alone or could enhance chemosensitivity on the human neuroblastoma cell line SH-SY5Y to cisplatin.Methods: The human neuroblastoma SH-SY5Y cells were cultured and treated with different concentrations of esomeprazole, pantoprazole, and cisplatin alone. Also, these cells exposed to cisplatin+ esomeprazole and cisplatin + pantoprazole combinations, respectively and incubated 24 h. The antiproliferative activities of the (PPIs) alone or in a combination of cisplatin was evaluated using the XTT colorimetric assay.Results: According to experimental data, neither PPIs showed no cytotoxicity on the human neuroblastoma cell line SH-SY5Y at all concentrations. However, when combined with cisplatin separately, they were found to have significant antiproliferative effects on the human neuroblastoma SH-SY5Y cell lines when compared to cell lines treated with cisplatin alone (p<0.05).Conclusions: Taken together, the inhibition of V-ATPase via esomeprazole and pantoprazole might enhance the chemosensitivity of cisplatin on the human neuroblastoma cell line SH-SY5Y. However, further studies are needed to be able to utilize PPIs in human neuroblastoma cells.

Cytokinetics of a Human Neuroblastoma Cell Line Following Treatment with Dianhydrogalactitol

1985 ◽  
Vol 3 (4) ◽  
pp. 321-325
Author(s):  
Peter P. Sordillo ◽  
Michael Andreeff ◽  
Lawrence Helson ◽  
James Steinmetz ◽  
Myron R. Melamed
Keyword(s):  
Cell Line ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Human Neuroblastoma Cell Line ◽  
Line Following
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