scholarly journals Analysis of 11 candidate genes in 849 adult patients with suspected hereditary cancer predisposition

2020 ◽  
Vol 60 (2) ◽  
pp. 73-78
Author(s):  
Mathias Cavaillé ◽  
Nancy Uhrhammer ◽  
Maud Privat ◽  
Flora Ponelle‐Chachuat ◽  
Mathilde Gay‐Bellile ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Hereditary Cancer ◽  
Cancer Predisposition ◽  
Adult Patients ◽  
Hereditary Cancer Predisposition

Melanoma candidate genes CDKN2A/p16/INK4A, p14ARF, and CDK4 sequencing in patients with uveal melanoma with relative high-risk for hereditary cancer predisposition

2011 ◽  
Vol 21 (3) ◽  
pp. 175-179 ◽  
Author(s):  
Mohamed H. Abdel-Rahman ◽  
Robert Pilarski ◽  
James B. Massengill ◽  
Benjamin N. Christopher ◽  
Ryan Noss ◽  
...  
Keyword(s):  
High Risk ◽  
Candidate Genes ◽  
Uveal Melanoma ◽  
Hereditary Cancer ◽  
Cancer Predisposition ◽  
P16 Ink4a ◽  
Hereditary Cancer Predisposition

A surveillance clinic for children and adolescents with, or at risk of, hereditary cancer predisposition syndromes

2021 ◽  
Vol 214 (7) ◽  
pp. 335
Author(s):  
Nicholas Leedman ◽  
Murray Princehorn ◽  
Nicholas Gottardo ◽  
Claire Franklin ◽  
Rebecca D'Souza ◽  
...  
Keyword(s):  
At Risk ◽  
Children And Adolescents ◽  
Hereditary Cancer ◽  
Cancer Predisposition ◽  
Hereditary Cancer Predisposition

Primer on Hereditary Cancer Predisposition Genes Included Within Somatic Next-Generation Sequencing Panels

2019 ◽  
pp. 1-11
Author(s):  
Zade Akras ◽  
Brandon Bungo ◽  
Brandie H. Leach ◽  
Jessica Marquard ◽  
Manmeet Ahluwalia ◽  
...  
Keyword(s):  
Hereditary Cancer ◽  
Cancer Susceptibility ◽  
Cancer Predisposition ◽  
Comprehensive Overview ◽  
Germline Variants ◽  
Cancer Susceptibility Genes ◽  
Germline Genes ◽  
Number Of Genes ◽  
Predisposition Genes ◽  
Hereditary Cancer Predisposition

PURPOSE It has been estimated that 5% to 10% of cancers are due to hereditary causes. Recent data sets indicate that the incidence of hereditary cancer may be as high as 17.5% in patients with cancer, and a notable subset is missed if screening is solely by family history and current syndrome-based testing guidelines. Identification of germline variants has implications for both patients and their families. There is currently no comprehensive overview of cancer susceptibility genes or inclusion of these genes in commercially available somatic testing. We aimed to summarize genes linked to hereditary cancer and the somatic and germline panels that include such genes. METHODS Germline predisposition genes were chosen if commercially available for testing. Penetrance was defined as low, moderate, or high according to whether the gene conferred a 0% to 20%, 20% to 50%, or 50% to 100% lifetime risk of developing the cancer or, when percentages were not available, was estimated on the basis of existing literature descriptions. RESULTS We identified a total of 89 genes linked to hereditary cancer predisposition, and we summarized these genes alphabetically and by organ system. We considered four germline and six somatic commercially available panel tests and quantified the coverage of germline genes across them. Comparison between the number of genes that had germline importance and the number of genes included in somatic testing showed that many but not all germline genes are tested by frequently used somatic panels. CONCLUSION The inclusion of cancer-predisposing genes in somatic variant testing panels makes incidental germline findings likely. Although somatic testing can be used to screen for germline variants, this strategy is inadequate for comprehensive screening. Access to genetic counseling is essential for interpretation of germline implications of somatic testing and implementation of appropriate screening and follow-up.

Utilization of Multigene Panels in Hereditary Cancer Predisposition Testing

2015 ◽  
pp. 459-482
Author(s):  
Holly LaDuca ◽  
Tina Pesaran ◽  
Aaron M. Elliott ◽  
Virginia Speare ◽  
Jill S. Dolinsky ◽  
...  
Keyword(s):  
Hereditary Cancer ◽  
Cancer Predisposition ◽  
Multigene Panels ◽  
Hereditary Cancer Predisposition

scholarly journals Pancreatic cancer as a sentinel for hereditary cancer predisposition

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Erin L. Young ◽  
Bryony A. Thompson ◽  
Deborah W. Neklason ◽  
Matthew A. Firpo ◽  
Theresa Werner ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Hereditary Cancer ◽  
Cancer Predisposition ◽  
Hereditary Cancer Predisposition

Lack of GNAQ germline mutations in uveal melanoma patients with high risk for hereditary cancer predisposition

2010 ◽  
Vol 10 (2) ◽  
pp. 319-321 ◽  
Author(s):  
Mohamed H. Abdel-Rahman ◽  
Robert Pilarski ◽  
James B. Massengill ◽  
Benjamin B. Christopher ◽  
Frederick H. Davidorf
Keyword(s):  
High Risk ◽  
Uveal Melanoma ◽  
Hereditary Cancer ◽  
Germline Mutations ◽  
Cancer Predisposition ◽  
Melanoma Patients ◽  
Hereditary Cancer Predisposition
Sign in / Sign up

Export Citation Format

Share Document