HnRNPM and CD44s expression affects tumor aggressiveness and predicts poor prognosis in breast cancer with axillary lymph node metastases

2017 ◽  
Vol 56 (8) ◽  
pp. 598-607 ◽  
Author(s):  
Huizhi Sun ◽  
Tieju Liu ◽  
Dongwang Zhu ◽  
Xueyi Dong ◽  
Fang Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Axillary Lymph Node ◽  
Poor Prognosis ◽  
Axillary Lymph ◽  
Tumor Aggressiveness ◽  
Axillary Lymph Node Metastases ◽  
Cd44s Expression ◽  
Node Metastases

scholarly journals Aldehyde dehydrogenase 1 (ALDH1) immunostaining in axillary lymph node metastases is an independent prognostic factor in ALDH1-positive breast cancer

2021 ◽  
Vol 49 (10) ◽  
pp. 030006052110472
Author(s):  
Xin Guan ◽  
Yi Dong ◽  
Zhimin Fan ◽  
Yue Zhan ◽  
Xinpeng Xie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Aldehyde Dehydrogenase ◽  
Lymph Node Metastases ◽  
Axillary Lymph Node ◽  
Poor Prognosis ◽  
Axillary Lymph ◽  
Axillary Lymph Node Metastases ◽  
Node Metastases

Objective To determine whether aldehyde dehydrogenase 1 (ALDH1) immunostaining in axillary lymph node metastases in patients with breast cancer is associated with poor clinical prognosis. Methods This retrospective study reviewed data from the medical records of patients with immunohistochemistry-confirmed invasive ductal carcinoma (IDC) and 1–3 metastatic lymph nodes in the ipsilateral axilla between December 2012 and July 2015. The association between ALDH1 immunostaining in axillary lymph node metastases and clinical parameters and prognosis was analysed using χ2-test, Kaplan–Meier survival analysis, univariate and multivariate Cox regression analyses. Results A total of 229 patients with IDC were enrolled in the study. The median follow-up was 61 months (range, 20–89 months). Patients with ALDH1-positive axillary lymph node metastases had significantly shorter relapse-free survival and overall survival compared with those with ALDH1-negative axillary lymph node metastases. ALDH1 immunostaining in axillary lymph node metastases was a significant predictor of poor prognosis in univariate and multivariate analyses. Conclusion This large study with long-term follow-up suggests that ALDH1 immunostaining in axillary lymph node metastases is an independent predictor of poor prognosis in patients with breast cancer. The clinical relevance of this finding should be confirmed in further well-designed prospective studies.

Predictors of axillary lymph node metastases in patients with impalpable breast cancer

The Breast ◽  
1997 ◽  
Vol 6 (3) ◽  
pp. 143-145 ◽  
Author(s):  
C.I. Perre ◽  
V.C.M. Koot ◽  
E.P.A. van der Heijden ◽  
V. Vossen ◽  
J.R. de Jong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Axillary Lymph Node ◽  
Axillary Lymph ◽  
Axillary Lymph Node Metastases ◽  
Node Metastases

The Importance of Extracapsular Extension of Axillary Lymph Node Metastases in Breast Cancer

2004 ◽  
Vol 90 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Görken Bilkay İlknur ◽  
Alanyali Hilmi ◽  
Canda Tülay ◽  
Çetinayak Oguz ◽  
Sengiz Selma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Axillary Lymph Node ◽  
Axillary Lymph ◽  
Extracapsular Extension ◽  
Axillary Lymph Node Metastases ◽  
Node Metastases

Axillary lymph node metastases in breast cancer: preoperative detection with US.

Radiology ◽  
1986 ◽  
Vol 158 (2) ◽  
pp. 325-326 ◽  
Author(s):  
J N Bruneton ◽  
E Caramella ◽  
M Héry ◽  
D Aubanel ◽  
J J Manzino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Axillary Lymph Node ◽  
Axillary Lymph ◽  
Axillary Lymph Node Metastases ◽  
Node Metastases
Sign in / Sign up

Export Citation Format

Share Document