scholarly journals Copy number gain of 11q13.3 genes associates with pathological stage in hypopharyngeal squamous cell carcinoma

2016 ◽  
Vol 56 (3) ◽  
pp. 185-198 ◽  
Author(s):  
Samuel B. Pattle ◽  
Natasa Utjesanovic ◽  
Athena Togo ◽  
Lucy Wells ◽  
Brendan Conn ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Copy Number ◽  
Copy Number Gain ◽  
Pathological Stage ◽  
Hypopharyngeal Squamous Cell Carcinoma

scholarly journals MicroRNA induction by copy number gain is associated with poor outcome in squamous cell carcinoma of the lung

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Endi Xia ◽  
Sotaro Kanematsu ◽  
Yusuke Suenaga ◽  
Asmaa Elzawahry ◽  
Hitomi Kondo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Copy Number ◽  
Copy Number Gain ◽  
Poor Outcome

Recurrent copy number gain of transcription factorSOX2and corresponding high protein expression in oral squamous cell carcinoma

2010 ◽  
Vol 49 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Kolja Freier ◽  
Karl Knoepfle ◽  
Christa Flechtenmacher ◽  
Susanne Pungs ◽  
Frauke Devens ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Copy Number ◽  
Copy Number Gain ◽  
High Protein

Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma

2016 ◽  
Vol 468 (5) ◽  
pp. 579-587 ◽  
Author(s):  
Diána Brauswetter ◽  
Kornél Dános ◽  
Bianka Gurbi ◽  
Éva Fruzsina Félegyházi ◽  
Ede Birtalan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Copy Number ◽  
Poor Prognosis ◽  
Copy Number Gain ◽  
Neck Squamous Cell Carcinoma

scholarly journals Copy number gain and oncogenic activity of YWHAZ/14-3-3ζ in head and neck squamous cell carcinoma

2009 ◽  
Vol 125 (3) ◽  
pp. 603-611 ◽  
Author(s):  
Mauting Lin ◽  
Carl D. Morrison ◽  
Susie Jones ◽  
Nehad Mohamed ◽  
Jason Bacher ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Copy Number ◽  
Copy Number Gain ◽  
Neck Squamous Cell Carcinoma ◽  
Oncogenic Activity

scholarly journals The prognostic significance of MCL1 copy number gain in esophageal squamous cell carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (50) ◽  
pp. 87699-87709 ◽  
Author(s):  
Chen Xu ◽  
Yalan Liu ◽  
Jie Huang ◽  
Hao Wang ◽  
Lijie Tan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Copy Number ◽  
Prognostic Significance ◽  
Copy Number Gain

scholarly journals New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases

2021 ◽  
Vol 22 (6) ◽  
pp. 2831
Author(s):  
Ryan Bensen ◽  
John Brognard
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Fate ◽  
Squamous Cell ◽  
Copy Number Gain ◽  
Genetic Alterations ◽  
Distal Portion ◽  
Squamous Cell Carcinomas ◽  
Cell Fate Decisions ◽  
Genetic Landscape

Squamous cell carcinomas of the lung, head and neck, esophagus, and cervix account for more than two million cases of cancer per year worldwide with very few targetable therapies available and minimal clinical improvement in the past three decades. Although these carcinomas are differentiated anatomically, their genetic landscape shares numerous common genetic alterations. Amplification of the third chromosome’s distal portion (3q) is a distinguishing genetic alteration in most of these carcinomas and leads to copy-number gain and amplification of numerous oncogenic proteins. This area of the chromosome harbors known oncogenes involved in squamous cell fate decisions and differentiation, including TP63, SOX2, ECT2, and PIK3CA. Furthermore, novel targetable oncogenic kinases within this amplicon include PRKCI, PAK2, MAP3K13, and TNIK. TCGA analysis of these genes identified amplification in more than 20% of clinical squamous cell carcinoma samples, correlating with a significant decrease in overall patient survival. Alteration of these genes frequently co-occurs and is dependent on 3q-chromosome amplification. The dependency of cancer cells on these amplified kinases provides a route toward personalized medicine in squamous cell carcinoma patients through development of small-molecules targeting these kinases.

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