Occurrence of a non deleterious gene conversion event in theBRCA1gene

2015 ◽  
Vol 54 (10) ◽  
pp. 646-652 ◽  
Author(s):  
Chloé Tessereau ◽  
Mélanie Léoné ◽  
Monique Buisson ◽  
Laurent Duret ◽  
Olga M. Sinilnikova ◽  
...  
Keyword(s):  
Gene Conversion ◽  
Gene Conversion Event ◽  
Conversion Event ◽  
Deleterious Gene

Homothallic switching of Saccharomyces cerevisiae mating type genes by using a donor containing a large internal deletion

1985 ◽  
Vol 5 (8) ◽  
pp. 2154-2158
Author(s):  
B Weiffenbach ◽  
J E Haber
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Gene Conversion ◽  
Mating Type ◽  
Gene Conversion Event ◽  
Conversion Event ◽  
Base Pair Deletion ◽  
Mating Type Genes ◽  
Type Gene ◽  
Mat Locus ◽  
Donor Locus

Homothallic switching of the mating type genes of Saccharomyces cerevisiae occurs by a gene conversion event, replacing sequences at the expressed MAT locus with a DNA segment copied from one of two unexpressed loci, HML or HMR. The transposed Ya or Y alpha sequences are flanked by homologous regions that are believed to be essential for switching. We examined the transposition of a mating type gene (hmr alpha 1-delta 6) which contains a 150-base-pair deletion spanning the site where the HO endonuclease generates a double-stranded break in MAT that initiates the gene conversion event. Despite the fact that the ends of the cut MAT region no longer share homology with the donor hmr alpha 1-delta 6, switching of MATa or MAT alpha to mat alpha 1-delta 6 was efficient. However, there was a marked increase in the number of aberrant events, especially the formation of haploid-inviable fusions between MAT and the hmr alpha 1-delta 6 donor locus.

scholarly journals A potential donor gene for the bm1 gene conversion event in the C57BL mouse

Nature ◽  
1983 ◽  
Vol 306 (5945) ◽  
pp. 792-795 ◽  
Author(s):  
Andrew L. Mellor ◽  
Elizabeth H. Weiss ◽  
K. Ramachandran ◽  
Richard A. Flavell
Keyword(s):  
Gene Conversion ◽  
Gene Conversion Event ◽  
C57bl Mouse ◽  
Potential Donor ◽  
Conversion Event ◽  
Donor Gene

scholarly journals Homothallic switching of Saccharomyces cerevisiae mating type genes by using a donor containing a large internal deletion.

1985 ◽  
Vol 5 (8) ◽  
pp. 2154-2158 ◽  
Author(s):  
B Weiffenbach ◽  
J E Haber
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Gene Conversion ◽  
Mating Type ◽  
Gene Conversion Event ◽  
Conversion Event ◽  
Base Pair Deletion ◽  
Mating Type Genes ◽  
Type Gene ◽  
Mat Locus ◽  
Donor Locus

Homothallic switching of the mating type genes of Saccharomyces cerevisiae occurs by a gene conversion event, replacing sequences at the expressed MAT locus with a DNA segment copied from one of two unexpressed loci, HML or HMR. The transposed Ya or Y alpha sequences are flanked by homologous regions that are believed to be essential for switching. We examined the transposition of a mating type gene (hmr alpha 1-delta 6) which contains a 150-base-pair deletion spanning the site where the HO endonuclease generates a double-stranded break in MAT that initiates the gene conversion event. Despite the fact that the ends of the cut MAT region no longer share homology with the donor hmr alpha 1-delta 6, switching of MATa or MAT alpha to mat alpha 1-delta 6 was efficient. However, there was a marked increase in the number of aberrant events, especially the formation of haploid-inviable fusions between MAT and the hmr alpha 1-delta 6 donor locus.

RAD52-INDEPENDENT MITOTIC GENE CONVERSION IN SACCHAROMYCES CEREVISIAE FREQUENTLY RESULTS IN CHROMOSOMAL LOSS

Genetics ◽  
1985 ◽  
Vol 111 (1) ◽  
pp. 7-22
Author(s):  
James E Haber ◽  
Mark Hearn
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Gene Conversion ◽  
Mitotic Recombination ◽  
Gene Conversion Event ◽  
Intragenic Recombination ◽  
Wild Type ◽  
Conversion Event ◽  
Chromosomal Loss ◽  
Mitotic Gene Conversion ◽  
Striking Effect

ABSTRACT We have examined spontaneous, interchromosomal mitotic recombination events between his4 alleles in both Rad+ and rad52 strains of Saccharomyces cerevisiae. In Rad+ strains, 74% of the His+ prototrophs resulted from gene conversion events without exchange of flanking markers. In diploids homozygous for the rad52-1 mutation, the frequency of His+ prototroph formation was less than 5% of the wild-type value, and more than 80% of the gene conversion events were accompanied by an exchange of flanking markers. Most of the rad52 intragenic recombination events arose by gene conversion accompanied by an exchange of flanking markers and not by a simple reciprocal exchange between the his4A and his4C alleles. There were also profound effects on the kinds of recombinant products that were recovered. The most striking effect was that RAD52-independent mitotic recombination frequently results in the loss of one of the two chromosomes participating in the gene conversion event.

DQB1*0323 is the result of a gene conversion event between a DQB1*06 and a DQB1*030303 allele

2009 ◽  
Vol 73 (6) ◽  
pp. 624-625 ◽  
Author(s):  
S. Wienzek ◽  
M. Verboom ◽  
R. Blasczyk ◽  
G. Bein ◽  
P. A. Horn
Keyword(s):  
Gene Conversion ◽  
Gene Conversion Event ◽  
Conversion Event

A novel HLA allele derived from a likely DRB1/DRB3 gene conversion event: HLA-DRB3*01:15

2011 ◽  
Vol 78 (5) ◽  
pp. 405-407 ◽  
Author(s):  
J. J. Schiller ◽  
S. M. Gaba ◽  
T. R. Hasse ◽  
T. L. Fisher ◽  
T. M. Ellis
Keyword(s):  
Gene Conversion ◽  
Gene Conversion Event ◽  
Conversion Event

Identification of HLA-G*01:17, a new allele possibly generated by an interloci gene conversion event involving exon 3 of HLA-B

2011 ◽  
Vol 72 (3) ◽  
pp. 238-240 ◽  
Author(s):  
Chris Czarnecki ◽  
Gary Van Domselaar ◽  
Joanne Embreé ◽  
Robert Brunham ◽  
Francis A. Plummer ◽  
...  
Keyword(s):  
Gene Conversion ◽  
Gene Conversion Event ◽  
Conversion Event

scholarly journals Long‐read nanopore sequencing resolves a TMEM231 gene conversion event causing Meckel–Gruber syndrome

2019 ◽  
Vol 41 (2) ◽  
pp. 525-531 ◽  
Author(s):  
Christopher M. Watson ◽  
Philip Dean ◽  
Nick Camm ◽  
Jennifer Bates ◽  
Ian M. Carr ◽  
...  
Keyword(s):  
Gene Conversion ◽  
Gene Conversion Event ◽  
Nanopore Sequencing ◽  
Conversion Event ◽  
Long Read
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