Identification of genetic alterations in upper urinary tract urothelial carcinoma in end-stage renal disease patients

2010 ◽  
Vol 49 (10) ◽  
pp. 928-934 ◽  
Author(s):  
Ching-Fang Wu ◽  
See-Tong Pang ◽  
Jia-Jen Shee ◽  
Phei-Lang Chang ◽  
Cheng-Keng Chuang ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Renal Disease ◽  
Urothelial Carcinoma ◽  
End Stage Renal Disease ◽  
Genetic Alterations ◽  
Upper Urinary Tract ◽  
Stage Renal Disease ◽  
End Stage ◽  
Urinary Tract Urothelial Carcinoma

scholarly journals Propensity-Matched Survival Analysis of Upper Urinary Tract Urothelial Carcinomas between End-Stage Renal Disease with and without Kidney Transplantation

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Hao Lun Luo ◽  
Po Hui Chiang ◽  
Yuan Tso Cheng ◽  
Yen Ta Chen
Keyword(s):  
Kidney Transplantation ◽  
Urinary Tract ◽  
Propensity Score ◽  
Urothelial Carcinoma ◽  
End Stage Renal Disease ◽  
Upper Urinary Tract ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients ◽  
Urinary Tract Urothelial Carcinoma

Urothelial carcinoma is the most common cancer following kidney transplantation (KT) in Taiwan. Unusual presentation of upper urinary tract urothelial carcinoma (UTUC) is noted in Taiwan and China. As the post-KT-UTUC oncological course is not fully understood, the aim of this study is to identify postulated significant differences for the clinical cancer course of UTUC among end-stage renal disease (ESRD) patients with and without KT. From 2005 January to 2016 March, 194 ESRD patients underwent radical nephroureterectomy due to UTUC in our hospital. The parameters were obtained from the chart record and pathology report. SPSS version 21 software was used for all statistical analyses. Unequal matching created study groups wherein a 0.2 caliper width was performed for adjusting these confounding pathological factors. Propensity score-matching cohort was performed for each population first, and then for all the study patients. We observed that the average age of UTUC in ESRD patients after KT was younger than in those without KT. The pathological factors such as stage, bladder cancer history, papillary structure, lymphovascular invasion, and variant histology were equal in these two groups. However, younger onset (p<0.001), more multifocal tumors, and carcinomas in situ were observed in post-KT UTUC (p<0.001 and 0.006, respectively). After adjustment of pathological factors by propensity score-matched analysis, the 5-year systemic UTUC recurrence was significantly more in ESRD after KT compared with ESRD without KT (p=0.03). No obvious difference in 5-year cancer related death could be observed between these two groups (p=0.314). Post-kidney transplantation upper urinary tract urothelial carcinoma in Taiwan is relatively common, has younger onset, and is associated with aggressive pathological features. The oncologic outcome of UTUC after KT is poor in our observation, even after propensity scored-matched analysis. It indicates the immunosuppression status is still associated with more malignant UTUC behavior.

End-stage renal disease in the course of urinary tract defects in Wolf–Hirschhorn syndrome – case report

2014 ◽  
Vol 1 (2) ◽  
pp. 229-236
Author(s):  
Katarzyna Jungiewicz ◽  
◽  
Irena Makulska ◽  
Anna Medyńska ◽  
Danuta Zwolińska ◽  
...  
Keyword(s):  
Case Report ◽  
Urinary Tract ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

Clinical Study of Urinary Tract Tumors in Patients with Maintenance Dialysis for End Stage Renal Disease

2019 ◽  
Vol 3 (1) ◽  
pp. 9-12
Author(s):  
Chang-Li Xu ◽  
Hui Xu ◽  
Jin-Qi Song ◽  
Ya-Nan Zhou
Keyword(s):  
Urinary Tract ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Causes Of Death ◽  
Dialysis Patients ◽  
Gross Hematuria ◽  
Maintenance Dialysis ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Impact

Introduction: The research in the past ten years shows that the incidence of malignant tumors in dialysis patients is significantly higher than that in normal people. The highest proportion of urinary tumors is one of the main causes of death in patients with end-stage renal disease, and the incidence is gradually increasing. However, the high-risk factors of urinary tract tumors in dialysis patients have not yet been fully elucidated, so exploring this issue is an important issue that the medical community needs to solve. The objectives of this study are to understand the clinical characteristics of maintenance dialysis patients with urinary tract tumors and the influence of related factors on their prognosis. Methods: The clinical data of 22 patients with urinary tract tumors in maintenance dialysis (MHD) from the Affiliated Hospital of Chengde Medical College from January 2013 to June 2018 were retrospectively analyzed. The incidence of urinary tumors and clinical diagnosis and treatment were investigated. And prognosis, analysis of the impact of various relevant factors on the overall survival of patients with dialysis and urinary tumors. Results: The 912 patients with maintenance dialysis, 22 patients had urinary tumors with an incidence of 2.41%. Among them, 13 patients were bladder tumors, 7 patients were renal or ureteral tumors, 1 patient was renal tumor, and 1 patient was prostate cancer. There were 17 cases of intermittent and painless gross hematuria, 2 cases of gross hematuria, 1 case of lumbar pain, 1 case of abdominal pain and dysuria, 1 case of frequent urination and dysuria. Ten patients underwent surgery, and 4 patients died. The postoperative survival of the patients was 12~103 months, with an average of 58.75 months. 12 patients were unable to undergo surgery because of other diseases or economic reasons; in 9 the disease was found during autopsy. The time from tumor to death was 14~38 months, with an average of 24.11 months. The causes of death in 13 death patients: 5 patients were myocardial infarction, 3 patients were heart failure, 3 patients were tumor metastasis, and severe sepsis in 2 patients. Conclusion: There is increased propensity of GU tumors in maintenance dialysis patients. The tumors are of higher grade and demonstrate poor prognosis. Therefore, attention should be paid to the monitoring of urinary tract tumors in maintenance dialysis patients, especially elderly patients without cardiovascular and cerebrovascular complications, because their life expectancy can be longer.

scholarly journals Urinary Tract Infection in Hemodialysis-Dependent End-Stage Renal Disease Patients

2022 ◽  
Vol Volume 14 ◽  
pp. 7-15
Author(s):  
Kaori Yamashita ◽  
Yudai Ishiyama ◽  
Maki Yoshino ◽  
Hidekazu Tachibana ◽  
Daisuke Toki ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage
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