Multiple recurrent chromosomal breakpoints in mantle cell lymphoma revealed by a combination of molecular cytogenetic techniques

2008 ◽  
Vol 47 (12) ◽  
pp. 1086-1097 ◽  
Author(s):  
Itziar Salaverria ◽  
Blanca Espinet ◽  
Ana Carrió ◽  
Dolors Costa ◽  
Laura Astier ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Molecular Cytogenetic ◽  
Mantle Cell ◽  
Chromosomal Breakpoints ◽  
Molecular Cytogenetic Techniques

Molecular cytogenetic study of a mantle cell lymphoma with a complex translocation involving the CCND1 (11q13) region

2004 ◽  
Vol 154 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Sonia Maravelaki ◽  
Anna Burford ◽  
Andrew Wotherspoon ◽  
Rajeev Joshi ◽  
Estela Matutes ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Cytogenetic Study ◽  
Complex Translocation ◽  
Molecular Cytogenetic ◽  
Mantle Cell

Molecular cytogenetic characterization of the mantle cell lymphoma cell line GRANTA-519

2004 ◽  
Vol 153 (2) ◽  
pp. 144-150 ◽  
Author(s):  
C. Rudolph ◽  
D. Steinemann ◽  
N. von Neuhoff ◽  
D. Gadzicki ◽  
T. Ripperger ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Line ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Lymphoma Cell Line ◽  
Molecular Cytogenetic ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell ◽  
Cytogenetic Characterization

Molecular Cytogenetic Approach to the Diagnosis of Splenic Lymphoma: A Case Report of Blastoid Mantle Cell Lymphoma

2003 ◽  
Vol 44 (7) ◽  
pp. 1229-1234 ◽  
Author(s):  
Erik Björck ◽  
Ola Landgren ◽  
Jacqueline Schoumans ◽  
Birger Christensson ◽  
Magnus Björkholm ◽  
...  
Keyword(s):  
Case Report ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Molecular Cytogenetic ◽  
Mantle Cell ◽  
Splenic Lymphoma

scholarly journals Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization

Blood ◽  
1996 ◽  
Vol 88 (4) ◽  
pp. 1177-1182 ◽  
Author(s):  
JW Vaandrager ◽  
E Schuuring ◽  
E Zwikstra ◽  
CJ de Boer ◽  
KK Kleiverda ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Chromosomal Translocations ◽  
Direct Visualization ◽  
Mantle Cell ◽  
Chromosomal Breakpoints ◽  
Translocation Breakpoints

Several hematologic malignancies are associated with specific chromosomal translocations. Because of the dispersed distribution, chromosomal breakpoints may be difficult to detect using molecular techniques. We present a new application of a recently developed method, DNA fiber fluorescence in situ hybridization (fiber FISH), which allows direct visualization and mapping of chromosomal breakpoints. We tested this method for detection of the t(11;14)(q13;q32) translocation in mantle cell lymphoma. In DNA fiber FISH, a series of fluorochrome-labeled DNA probes covering several hundreds of kilobasepairs is hybridized to linear DNA molecules (or fibers) prepared from frozen tissue or intact cells. By using alternate fluorescent colors, a potential breakpoint region is stained in a color barcode pattern. Breaks in this region will split the barcode in two complementary parts, from which the breakpoint position can be derived. We used a 250-kb barcode covering the BCL-1 locus to detect 11q13 breakpoints in 20 well-characterized mantle cell lymphomas. A t(11;14) was shown by cohybridization of these probes with probes for the Ig heavy chain locus at 14q32. In 18 of 20 mantle cell lymphomas, a breakpoint within the 11q13/BCL-1 barcode was shown by the presence of multiple, complementary translocation products. Fusion of 11q13 and 14q32 sequences on single fibers indicating t(11;14)(q13;q32) was found in all 18 breakpoint-positive mantle cell lymphomas. In one additional case, fusion of an intact 11q13 barcode with 14q32 sequences indicated a breakpoint 100 kb centromeric of the major translocation cluster of BCL-1. Within the 120-kb region of BCL-1, breakpoints were widely scattered. This explains why, so far, a BCL-1 breakpoint had been detected by Southern blot analysis in only 10 of 19 cases. DNA fiber FISH analysis showed a t(11;14) in 95% of mantle cell lymphoma. The results indicate that DNA fiber FISH is a rapid, simple, and equally powerful method for detection of clustered and dispersed translocation breakpoints.

Molecular cytogenetic analysis of leukemic mantle cell lymphoma with a cryptic t(11;14)

2006 ◽  
Vol 165 (2) ◽  
pp. 172-175 ◽  
Author(s):  
Hege Vangstein Aamot ◽  
Geir E. Tjønnfjord ◽  
Jan Delabie ◽  
Sverre Heim
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cytogenetic Analysis ◽  
Cell Lymphoma ◽  
Molecular Cytogenetic ◽  
Mantle Cell

Mantle Cell Lymphoma Rising in Association with Inverted Papilloma

2019 ◽  
Author(s):  
Charles Tong ◽  
Peter Papagiannopoulos ◽  
Michael Feldman ◽  
Nithin Adappa ◽  
James Palmer
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Inverted Papilloma ◽  
Mantle Cell

Mantle Cell Lymphoma Presenting with Unusual Morphology in an Adolescent Female: A Case Report and Review of the Literature

2006 ◽  
Vol preprint (2007) ◽  
pp. 1
Author(s):  
Kristi Smock ◽  
Hassan Yaish ◽  
Mitchell Cairo ◽  
Mark Lones ◽  
Carlynn Willmore-Payne ◽  
...  
Keyword(s):  
Case Report ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Adolescent Female ◽  
Review Of The Literature ◽  
Mantle Cell
Sign in / Sign up

Export Citation Format

Share Document