The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer

2006 ◽  
Vol 45 (7) ◽  
pp. 639-645 ◽  
Author(s):  
Outi R. Saramäki ◽  
Teuvo L. J. Tammela ◽  
Paula M. Martikainen ◽  
Robert L. Vessella ◽  
Tapio Visakorpi
Keyword(s):  
Prostate Cancer ◽  
Late Stage ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Enhancer Of Zeste ◽  
Group Protein

Identification of polycomb group protein enhancer of zeste homolog 2 (EZH2)-derived peptides immunogenic in HLA-A24+ prostate cancer patients

The Prostate ◽  
2004 ◽  
Vol 60 (4) ◽  
pp. 273-281 ◽  
Author(s):  
Rika Ogata ◽  
Satoko Matsueda ◽  
Akihisa Yao ◽  
Masanori Noguchi ◽  
Kyogo Itoh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Enhancer Of Zeste ◽  
Group Protein

scholarly journals Enhancer of Zeste Homolog 2 Overexpression Has a Role in the Development of Anaplastic Thyroid Carcinomas

2011 ◽  
Vol 96 (4) ◽  
pp. 1029-1038 ◽  
Author(s):  
Eleonora Borbone ◽  
Giancarlo Troncone ◽  
Angelo Ferraro ◽  
Zuzana Jasencakova ◽  
Lovorka Stojic ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Anaplastic Thyroid Carcinoma ◽  
Polycomb Group ◽  
Migration And Invasion ◽  
Polycomb Group Protein ◽  
Expression Levels ◽  
Thyroid Carcinomas ◽  
Enhancer Of Zeste ◽  
Pax8 Gene ◽  
Group Protein

Abstract Context: Enhancer of zeste homolog 2 (EZH2) is a histone lysine methyltransferase belonging to the polycomb group protein family. Overexpression of EZH2 has been found in several human malignancies including hematological and solid tumors. Objectives: In this study we investigated the expression levels of EZH2 and its polycomb group protein partners in thyroid carcinoma tissues with different degrees of malignancy to identify potential new therapeutic targets for anaplastic thyroid carcinoma (ATC). Results: We show that high EZH2 expression levels are characteristic of undifferentiated ATC, whereas no significant changes were observed in well-differentiated papillary and follicular thyroid carcinomas as compared with normal thyroid. Knockdown of EZH2 in ATC cell lines results in cell growth inhibition, loss of anchorage-independent growth, migration, and invasion properties. Moreover, we demonstrate that EZH2 directly controls differentiation of ATC cells by silencing the thyroid specific transcription factor paired-box gene 8 (PAX8). Conclusions: EZH2 is specifically overexpressed in ATC, and it directly contributes to transcriptional silencing of PAX8 gene and ATC differentiation.

scholarly journals The polycomb group protein EZH2 is involved in progression of prostate cancer

Nature ◽  
2002 ◽  
Vol 419 (6907) ◽  
pp. 624-629 ◽  
Author(s):  
Sooryanarayana Varambally ◽  
Saravana M. Dhanasekaran ◽  
Ming Zhou ◽  
Terrence R. Barrette ◽  
Chandan Kumar-Sinha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Group Protein

Expression Profile of the Polycomb Group Protein Enhancer of Zeste Homologue 2 and its Prognostic Relevance in Renal Cell Carcinoma

2009 ◽  
Vol 182 (6) ◽  
pp. 2920-2925 ◽  
Author(s):  
Stefan Hinz ◽  
Steffen Weikert ◽  
Ahmed Magheli ◽  
Michèle Hoffmann ◽  
Rainer Engers ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Expression Profile ◽  
Renal Cell ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Prognostic Relevance ◽  
Enhancer Of Zeste ◽  
Group Protein

The polycomb group protein EZH2 regulates actin polymerization in human prostate cancer cells

The Prostate ◽  
2008 ◽  
Vol 68 (3) ◽  
pp. 255-263 ◽  
Author(s):  
R.J. Bryant ◽  
S.J. Winder ◽  
S.S. Cross ◽  
F.C. Hamdy ◽  
V.T. Cunliffe
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Actin Polymerization ◽  
Polycomb Group ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Polycomb Group Protein ◽  
Prostate Cancer Cells ◽  
Group Protein
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