Peculiar structure and location of 9p21 homozygous deletion breakpoints in human cancer cells

2003 ◽  
Vol 37 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Andrea R. Florl ◽  
Wolfgang A. Schulz
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Homozygous Deletion ◽  
Human Cancer Cells

scholarly journals FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Yichao Fan ◽  
Jiao Yue ◽  
Mengtao Xiao ◽  
Han Han-Zhang ◽  
Yao Vickie Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cells ◽  
Rna Binding ◽  
Cell Transformation ◽  
Human Cancer ◽  
Homozygous Deletion ◽  
Gene Promoters ◽  
Neighboring Gene ◽  
Human Cancer Cells ◽  
Human Cancers

Tumor suppressor p53 prevents cell transformation by inducing apoptosis and other responses. Homozygous TP53 deletion occurs in various types of human cancers for which no therapeutic strategies have yet been reported. TCGA database analysis shows that the TP53 homozygous deletion locus mostly exhibits co-deletion of the neighboring gene FXR2, which belongs to the Fragile X gene family. Here, we demonstrate that inhibition of the remaining family member FXR1 selectively blocks cell proliferation in human cancer cells containing homozygous deletion of both TP53 and FXR2 in a collateral lethality manner. Mechanistically, in addition to its RNA-binding function, FXR1 recruits transcription factor STAT1 or STAT3 to gene promoters at the chromatin interface and regulates transcription thus, at least partially, mediating cell proliferation. Our study anticipates that inhibition of FXR1 is a potential therapeutic approach to targeting human cancers harboring TP53 homozygous deletion.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling

Antiproliferation Effects of Germinated-Korean Rough Rice Extract on Human Cancer Cells

2010 ◽  
Vol 39 (3) ◽  
pp. 325-330 ◽  
Author(s):  
Hyun-Young Kim ◽  
In-Guk Hwang ◽  
Eun-Mi Joung ◽  
Tae-Myoung Kim ◽  
Dae-Joong Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Rough Rice
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