Clinical significance of alterations of chromosome 8 detected by fluorescence in situ hybridization analysis in pathologic organ-confined prostate cancer

2002 ◽  
Vol 34 (4) ◽  
pp. 363-371 ◽  
Author(s):  
Norihiko Tsuchiya ◽  
Jeffrey M. Slezak ◽  
Michael M. Lieber ◽  
Erik J. Bergstralh ◽  
Robert B. Jenkins
Keyword(s):  
Prostate Cancer ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Clinical Significance ◽  
Hybridization Analysis ◽  
Chromosome 8

The Prognostic Impact of MYC Gene-Related Abnormalities on Multiple Myeloma Outcome through Fluorescence in situ Hybridization Analysis

2022 ◽  
Author(s):  
Yosuke Okada ◽  
Masahiro Teramoto ◽  
Noriaki Tachi ◽  
Toshikuni Kawamura ◽  
Toshikatsu Horiuchi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Chromosomal Abnormalities ◽  
Hybridization Analysis ◽  
Chromosome 8 ◽  
Prognostic Impact ◽  
Additional Chromosome ◽  
Myc Gene

Introduction: Chromosomal abnormalities (CAs) have been identified as important factors in determining the biological features and prognostic value of multiple myeloma (MM). MYC gene-related abnormalities (MYC GAs) are one of the CAs, but its unfavorable impact has not been fully investigated in daily clinical practice. Methods: This study retrospectively analyzed the prognostic impact of MYC GAs on 81 patients through fluorescence in situ hybridization analysis in our institute. Results: MYC GAs were associated with poor overall survival (hazard ratio [HR], 3.08; 95% confidence interval [CI], 1.23–7.73; p = 0.017), progression-free survival (PFS) (HR, 2.96; 95% CI, 1.58–5.53; p < 0.001), and time to next treatment (TNT) (HR, 2.11; 95% CI, 1.13–3.93; p = 0.018) in the median follow-up of 34.7 months. Furthermore, MYC GAs with an additional chromosome 8 (MYC-Ch8(+)) were associated with shorter PFS (HR, 3.15; 95% CI, 1.38–7.2; p = 0.0064), whereas MYC GAs without an additional chromosome 8 (MYC-Ch8(−)) were associated with shorter PFS (HR, 3.62; 95% CI, 1.51–8.68; p = 0.004) and shorter TNT (HR, 3.72; 95% CI, 1.41–9.81; p = 0.0078). Conclusion: These findings could help identify high-risk patients with MM. Further prospective studies are needed to confirm the significance of MYC GAs for the MM prognostic effect.

scholarly journals Fluorescence In situ Hybridization Analysis of Circulating Tumor Cells in Metastatic Prostate Cancer

2009 ◽  
Vol 15 (6) ◽  
pp. 2091-2097 ◽  
Author(s):  
Margaret A. Leversha ◽  
Jialian Han ◽  
Zahra Asgari ◽  
Daniel C. Danila ◽  
Oscar Lin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Metastatic Prostate Cancer ◽  
Hybridization Analysis

588: Detection of Chromosome 8 Alterations in Paired Needle Biopsy and Prostatectomy Specimens Using Fluorescence In-Situ Hybridization

2004 ◽  
Vol 171 (4S) ◽  
pp. 156-156
Author(s):  
Chandler D. Dora ◽  
Yasushi Kondo ◽  
Fusheng X. Lan ◽  
Jeffrey M. Slezak ◽  
Erik J. Bergstralh ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Needle Biopsy ◽  
Chromosome 8

scholarly journals Fluorescence in situ hybridization analysis of hindgut bacteria associated with the development of equine laminitis

2008 ◽  
Vol 10 (10) ◽  
pp. 2901-2901 ◽  
Author(s):  
Gabriel J. Milinovich ◽  
Darren J. Trott ◽  
Paul C. Burrell ◽  
Emma L. Croser ◽  
Rafat A. M. Al Jassim ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Hybridization Analysis
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