scholarly journals Improving antioxidant and antiproliferative activities of colla corii asini hydrolysates using ginkgo biloba extracts

2018 ◽  
Vol 6 (4) ◽  
pp. 765-772 ◽  
Author(s):  
Xiaobing Xu ◽  
Shangwei Guo ◽  
Xianghui Hao ◽  
Hui Ma ◽  
Yanping Bai ◽  
...  
Keyword(s):  
Ginkgo Biloba ◽  
Ginkgo Biloba Extracts ◽  
Colla Corii Asini ◽  
Antiproliferative Activities

Effect of Ginkgo biloba extract on rat hepatic microsomal CYP1A activity: role of ginkgolides, bilobalide, and flavonols

2004 ◽  
Vol 82 (1) ◽  
pp. 57-64 ◽  
Author(s):  
I fan Kuo ◽  
Jie Chen ◽  
Thomas K.H Chang
Keyword(s):  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Inhibitory Potency ◽  
Hepatic Microsomes ◽  
Cyp1a Activity ◽  
Ginkgo Biloba Extracts ◽  
The Individual ◽  
Vitro Effect

The present study investigated the in vitro effect of Ginkgo biloba extracts and some of the individual constituents (ginkgolides, bilobalide, and flavonols such as kaempferol, quercetin, isorhamnetin, and their glycosides) on CYP1A-mediated 7-ethoxyresorufin O-dealkylation in hepatic microsomes isolated from rats induced with β-naphthoflavone. G. biloba extract competitively inhibited CYP1A activity, with an apparent Ki value of 1.6 ± 0.4 µg/mL (mean ± SE). At the concentrations present in the G. biloba extracts, ginkgolides A, B, C, and J and bilobalide did not affect CYP1A activity, whereas kaempferol (IC50 = 0.006 ± 0.001 µg/mL, mean ± SE), isorhamnetin (0.007 ± 0.001 µg/mL), and quercetin (0.050 ± 0.003 µg/mL) decreased this activity. The monoglycosides (1 and 10 µg/mL) and diglycosides (10 µg/mL) of kaempferol and quercetin but not those of isorhamnetin also inhibited CYP1A activity. The order of inhibitory potency was kaempferol ~ isorhamnetin > quercetin, and for each of these flavonols the order of potency was aglycone >> monoglycoside > diglycoside. In summary, G. biloba extract competitively inhibited rat hepatic microsomal CYP1A activity, but the effect was not due to ginkgolides A, B, C, or J, bilobalide, kaempferol, quercetin, isorhamnetin, or the respective flavonol monoglycosides or diglycosides.Key words: bilobalide, CYP1A, cytochrome P450, Ginkgo biloba, ginkgolide, flavonol.

Pharmacological Uses of Ginkgo biloba Extracts for Cardiovascular Disease and Coronary Heart Diseases

2018 ◽  
Vol 15 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Zhiming Shu ◽  
Akhtar Hussain Sh ◽  
Mohamed Shahen ◽  
He Wang ◽  
Mahmoud Alagawany ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Ginkgo Biloba ◽  
Heart Diseases ◽  
Coronary Heart Diseases ◽  
Ginkgo Biloba Extracts

scholarly journals Effects of Various Ginkgo biloba Extracts and Proanthocyanidin on Hepatic Cytochrome P450 Activity in Rats

2004 ◽  
Vol 45 (6) ◽  
pp. 295-301 ◽  
Author(s):  
Tomomi SUGIYAMA ◽  
Kazumasa SHINOZUKA ◽  
Atsushi SANO ◽  
Shizuo YAMADA ◽  
Kaori ENDOH ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Ginkgo Biloba ◽  
Cytochrome P450 Activity ◽  
Ginkgo Biloba Extracts ◽  
P450 Activity ◽  
Hepatic Cytochrome

Effects of Ginkgo biloba extracts on diazepam metabolism: a pharmacokinetic study in healthy Chinese male subjects

2010 ◽  
Vol 66 (5) ◽  
pp. 503-509 ◽  
Author(s):  
Xiao-Cong Zuo ◽  
Bi-Kui Zhang ◽  
Su-Jie Jia ◽  
Shi-Kun Liu ◽  
Ling-Yun Zhou ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Ginkgo Biloba ◽  
Healthy Chinese ◽  
Ginkgo Biloba Extracts ◽  
Male Subjects ◽  
Chinese Male
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