scholarly journals Small amounts of ethanol attenuate folic acid stability in acidic beverages during storage

2017 ◽  
Vol 6 (1) ◽  
pp. 214-219 ◽  
Author(s):  
Kaori Kida ◽  
Muneaki Tomotake ◽  
Hiroshi Sasako ◽  
Yoshihito Matsuda ◽  
Naomi Sasaki ◽  
...  
Keyword(s):  
Folic Acid ◽  
Acid Stability ◽  
Acidic Beverages

Investigation of folic acid stability in fortified instant Asian noodles by use of capillary electrophoresis

2009 ◽  
Vol 112 (2) ◽  
pp. 507-514 ◽  
Author(s):  
Rodney Hau Fung Cheung ◽  
Jeff G. Hughes ◽  
Philip J. Marriott ◽  
Darryl M. Small
Keyword(s):  
Capillary Electrophoresis ◽  
Folic Acid ◽  
Acid Stability

scholarly journals Vitamin E-based Folic Acid Nanoemulsion: Formulation and Physical Evaluation for Oral Administration

2019 ◽  
Vol 7 (4) ◽  
pp. 304-313
Author(s):  
Annis Catur Adi ◽  
Christanto Christanto ◽  
Heni Rachmawati ◽  
Amirah Adlia
Keyword(s):  
Folic Acid ◽  
Vitamin E ◽  
Light Exposure ◽  
Entrapment Efficiency ◽  
Tween 20 ◽  
Acid Stability ◽  
Peg 400 ◽  
Globule Size ◽  
Optimum Formula ◽  
Physical And Chemical

Background: Folic acid is essential in many metabolic processes and DNA synthesis. Nevertheless, folic acid is not stable, pH-sensitive, and deteriorated upon light exposure. Objective: This work was aimed to improve folic acid stability within vitamin E-based nanoemulsion. Methods: The nanoemulsion was prepared with self-nanoemulsification method by mixing vitamin E oil, Tween 20, and PEG 400. A pseudoternary phase diagram was constructed with aqueous titration to determine the optimum ratio for the mixture. The globule size, pH and entrapment efficiency were included in the nanoemulsion characterizations. In addition, the influence of centrifugation, storage, and pH on physical and chemical stabilities of folic acid nanoemulsion was evaluated. Results: Optimum formula was obtained from vitamin E, Tween 20, and PEG 400 with the ratio of 1:11:1, and the folic acid amount was 8 mg. The size of folic acidloaded oil globule was 15.10 ± 1.51 nm, and the nanoemulsion pH was 6.24 ± 0.01. The nanoemulsion system was able to load the folic acid completely. Folic acid in nanoemulsion was stable after 14 days at room temperature, and it was more stable compared to folic acid in solution. In addition, the physical and chemical characteristics of folic acid in nanoemulsion was not affected by the simulated gastric condition. Conclusion: Hence, nanoemulsion is a promising strategy to enhance folic acid stability.

The Morphology of the Rat Kidney Following Folic Acid Administration

1970 ◽  
Vol 28 ◽  
pp. 200-201
Author(s):  
Aline Byrnes ◽  
Elsa E. Ramos ◽  
Minoru Suzuki ◽  
E.D. Mayfield
Keyword(s):  
Folic Acid ◽  
De Novo ◽  
Specific Activity ◽  
Rat Kidney ◽  
Present Report ◽  
Intracellular Localization ◽  
Male Rats ◽  
Renal Hypertrophy ◽  
Electron Microscopic ◽  
Biochemical Alterations

Renal hypertrophy was induced in 100 g male rats by the injection of 250 mg folic acid (FA) dissolved in 0.3 M NaHCO3/kg body weight (i.v.). Preliminary studies of the biochemical alterations in ribonucleic acid (RNA) metabolism of the renal tissue have been reported recently (1). They are: RNA content and concentration, orotic acid-c14 incorporation into RNA and acid soluble nucleotide pool, intracellular localization of the newly synthesized RNA, and the specific activity of enzymes of the de novo pyrimidine biosynthesis pathway. The present report describes the light and electron microscopic observations in these animals. For light microscopy, kidney slices were fixed in formalin, embedded, sectioned, and stained with H & E and PAS.

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