scholarly journals Protective effects of tea extracts against alcoholic fatty liver disease in mice via modulating cytochrome P450 2E1 expression and ameliorating oxidative damage

2021 ◽  
Vol 9 (10) ◽  
pp. 5626-5640
Author(s):  
Bang‐Yan Li ◽  
Qian‐Qian Mao ◽  
Ren‐You Gan ◽  
Shi‐Yu Cao ◽  
Xiao‐Yu Xu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Liver Disease ◽  
Oxidative Damage ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Protective Effects ◽  
Cytochrome P450 2E1 ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Protective effects of the herbal medicine goshajinkigan in a rat model of non-alcoholic fatty liver disease

2012 ◽  
Vol 33 (6) ◽  
pp. 373-376 ◽  
Author(s):  
Yoshihiko Hirotani ◽  
Ayae Doi ◽  
Tomoki Takahashi ◽  
Hanako Umezawa ◽  
Yoko Urashima ◽  
...  
Keyword(s):  
Liver Disease ◽  
Herbal Medicine ◽  
Fatty Liver ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Protective Effects ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice

2017 ◽  
Vol 806 ◽  
pp. 75-82 ◽  
Author(s):  
Xue Sun ◽  
Xingping Duan ◽  
Changyuan Wang ◽  
Zhihao Liu ◽  
Pengyuan Sun ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Glycyrrhizic Acid ◽  
Protective Effects ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Vanillic Acid and Non-Alcoholic Fatty Liver Disease: A Focus on AMPK in Adipose and Liver Tissues

2021 ◽  
Vol 27 ◽  
Author(s):  
Sepideh Shekari ◽  
Fatemeh Khonsha ◽  
Mohammad Rahmati-Yamchi ◽  
Hamid Reza Nejabati ◽  
Ali Mota
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Vanillic Acid ◽  
Fatty Liver Disease ◽  
Wide Spectrum ◽  
Special Focus ◽  
Protective Effects ◽  
Mice Model ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

: Non-alcoholic fatty liver disease (NAFLD), a growing health issue around the world, is defined as the presence of steatosis in the liver without any other detectable byproducts such as alcohol consumption which includes a wide spectrum of pathologies, such as steatohepatitis, cirrhosis, and hepatocellular carcinoma. A growing body of evidence indicates that the reduction in the 5' adenosine monophosphate-activated protein kinase (AMPK) activity, which could be activated by the consumption of the drugs, hormones, cytokines, and dietary restriction, is related to some metabolic disorders such as obesity, diabetes, PCOS, and NAFLD. Vanillic acid (VA), as an anti-inflammatory, anti-oxidative, anti-angiogenic and anti-metastatic factor, has protective effects on the liver as in two animal models of liver damage. It reduces serum levels of transaminases, inflammatory cytokines, and the accumulation of collagen in the liver and prevents liver fibrosis. Besides, it decreases body and adipose tissue weight in a mice model of obesity and, similar to the liver tissue, diminishes adipogenesis through the activation of AMPK. It has been reported that VA can target almost all of the metabolic abnormalities of NAFLD, such as hepatic steatosis, inflammation, and hepatic injury, at least partially through the activation of AMPK. Therefore, in this review, we will discuss the possible and hypothetical roles of VA in NAFLD, with a special focus on AMPK.

Diet-induced non-alcoholic fatty liver disease affects expression of major cytochrome P450 genes in a mouse model

2016 ◽  
Vol 68 (12) ◽  
pp. 1567-1576 ◽  
Author(s):  
Tsuyoshi Chiba ◽  
Keiko Noji ◽  
Shohei Shinozaki ◽  
Sachina Suzuki ◽  
Keizo Umegaki ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Liver Disease ◽  
Mouse Model ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Cytochrome P450 Genes ◽  
Alcoholic Fatty Liver Disease

Cytochrome P450 metabolism of vitamin E in models of non-alcoholic fatty liver disease and steatohepatitis

2015 ◽  
Vol 86 ◽  
pp. S42 ◽  
Author(s):  
Desirée Bartolini ◽  
Veronica Faccani ◽  
Angelo Russo ◽  
Vanessa Pieri ◽  
Pierangelo Torquato ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Liver Disease ◽  
Vitamin E ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
Sign in / Sign up

Export Citation Format

Share Document