scholarly journals Effects of Miao sour soup on hyperlipidemia in high‐fat diet‐induced obese rats via the AMPK signaling pathway

2021 ◽  
Author(s):  
Hongmei Yang ◽  
Jiao Xie ◽  
Nanlan Wang ◽  
Qianqian Zhou ◽  
Yang Lu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
High Fat Diet ◽  
High Fat ◽  
Ampk Signaling ◽  
Obese Rats

Involvement of Nuclear Related Factor 2 Signaling Pathway in the Brain of Obese Rats and Obesity-Resistant Rats Induced by High-Fat Diet

2016 ◽  
Vol 19 (4) ◽  
pp. 404-409 ◽  
Author(s):  
Wei-Wei Ma ◽  
Bing-Jie Ding ◽  
Li-Jing Wang ◽  
Yi Shao ◽  
Rong Xiao
Keyword(s):  
Signaling Pathway ◽  
High Fat Diet ◽  
Related Factor ◽  
High Fat ◽  
Obese Rats ◽  
The Brain

scholarly journals Obesity induced by high-fat diet promotes insulin resistance in the ovary

2010 ◽  
Vol 206 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Eliana H Akamine ◽  
Anderson C Marçal ◽  
João Paulo Camporez ◽  
Mara S Hoshida ◽  
Luciana C Caperuto ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
High Fat Diet ◽  
Ovarian Function ◽  
Polycystic Ovary ◽  
Insulin Signaling Pathway ◽  
Female Rats ◽  
High Fat ◽  
Obese Rats

Besides the effects on peripheral energy homeostasis, insulin also has an important role in ovarian function. Obesity has a negative effect on fertility, and may play a role in the development of the polycystic ovary syndrome in susceptible women. Since insulin resistance in the ovary could contribute to the impairment of reproductive function in obese women, we evaluated insulin signaling in the ovary of high-fat diet-induced obese rats. Female Wistar rats were submitted to a high-fat diet for 120 or 180 days, and the insulin signaling pathway in the ovary was evaluated by immunoprecipitation and immunoblotting. At the end of the diet period, we observed insulin resistance, hyperinsulinemia, an increase in progesterone serum levels, an extended estrus cycle, and altered ovarian morphology in obese female rats. Moreover, in female obese rats treated for 120 days with the high-fat diet, the increase in progesterone levels occurred together with enhancement of LH levels. The ovary from high-fat-fed female rats showed a reduction in the insulin receptor substrate/phosphatidylinositol 3-kinase/AKT intracellular pathway, associated with an increase in FOXO3a, IL1B, and TNFα protein expression. These changes in the insulin signaling pathway may have a role in the infertile state associated with obesity.

Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE−/− mice

2020 ◽  
Author(s):  
Weiqiang Chen ◽  
Xiaoli Zhang ◽  
Minwen Xu ◽  
Lixia Jiang ◽  
Min Zhou ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
High Fat Diet ◽  
High Fat ◽  
Ampk Signaling

scholarly journals Folic Acid Attenuates High-Fat Diet-Induced Osteoporosis Through the AMPK Signaling Pathway

2022 ◽  
Vol 9 ◽  
Author(s):  
Haiting He ◽  
Yaxi Zhang ◽  
Yue Sun ◽  
Yanwei Zhang ◽  
Jingjing Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Lipid Metabolism ◽  
Signaling Pathway ◽  
Systemic Inflammation ◽  
High Fat Diet ◽  
Water Soluble ◽  
Low Grade ◽  
High Fat ◽  
Ampk Signaling

Objective: Obesity caused by a high-fat diet (HFD) will expand adipose tissue and cause chronic low-grade systemic inflammation, leading to osteoporosis. Folic acid (FA) is a water-soluble vitamin that plays an essential role in regulating blood lipids and antioxidants. However, the effects and underlying mechanisms of FA in osteoporosis induced by an HFD remain poorly understood. This study aimed to investigate the effect of FA on bone health by using HFD-induced osteoporosis mice.Materials and Methods: Mice were fed a normal diet, HFD or an HFD supplemented with FA (20 μg/ml in drinking water) for 16 weeks. Throughout the 16 weeks study period, the rats were weighed once every week. GTT, ITT and lipid indexes were detected to evaluate the effects of FA on lipid metabolism in the HFD-fed mice. Morphological and structural changes of the femur and tibial bone were observed using micro-CT, HE staining and bone conversion parameters. The expression of MDA, SOD and inflammatory factors were detected to evaluate the effects of FA on oxidative stress and inflammatory response in the HFD-fed mice. Quantitative real-time PCR and Western blot (WB) were used to investigate the AMPK signaling pathway.Results: After the intervention of FA, the body fat rate of obese mice was reduced, and related metabolic disorders such as insulin resistance, hyperlipidemia, and systemic inflammation were alleviated. In correlation with those modifications, FA attenuated bone loss and improved bone microarchitecture, accompanied the number of osteoclasts and adipocytes decreased. Furthermore, FA promoted the phosphorylation of AMPK, thereby promoting the expression of Carnitine palmitoyltransferase 1 (CPT1), nuclear factor erythroid-2 related factor 2 (Nrf2) and antioxidant enzymes.Conclusion: These findings suggest that FA may modulate lipid metabolism and oxidative stress responses activating the AMPK signaling pathway, thereby alleviating HFD-induced osteoporosis. The results from our study provide experimental evidence to prevent HFD-induced osteoporosis.

Antiobesity activity of fermentedAngelicae gigantisby high fat diet-induced obese rats

2011 ◽  
pp. 1-11 ◽  
Author(s):  
Jae-Young Cha ◽  
Jae-Jun Jeong ◽  
Chang-Su Park ◽  
Hee-Young Ahn ◽  
Hyung-In Moon ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Obese Rats
Sign in / Sign up

Export Citation Format

Share Document