scholarly journals Boysenberry and apple juice concentrate reduced acute lung inflammation and increased M2 macrophage‐associated cytokines in an acute mouse model of allergic airways disease

2021 ◽  
Author(s):  
Odette M. Shaw ◽  
Roger D. Hurst ◽  
Janine Cooney ◽  
Gregory M. Sawyer ◽  
Hannah Dinnan ◽  
...  
Author(s):  
Odette M. Shaw ◽  
Roger D Hurst ◽  
Janine Cooney ◽  
Gregory M. Sawyer ◽  
Hannah Dinnan ◽  
...  

AbstractBioactive compounds such as anthocyanins, proanthocyanins and other polyphenols are found in a wide variety of fruits and vegetables, and consumption of these have been associated with reduced lung inflammation and improved lung function in asthma and other lung diseases. We investigated whether a combination of Boysenberry and apple juice, found in BerriQi® Boysenberry and apple juice concentrate, could reduce the allergic airways inflammation associated with asthma. We characterised the polyphenolic components in BerriQi® Boysenberry and apple juice concentrate and identified the main compounds as cyanidin glycosides, ellagitannins, and chlorogenic acid. We found that consumption of 2.5 mg/kg of total anthocyanins from the BerriQi® Boysenberry and apple juice concentrate significantly reduced eosinophil infiltration following acute ovalbumin (OVA) exposure in a mouse model of allergic airways inflammation. We found that BerriQi® Boysenberry and apple juice concentrate consumption increased M2 (CD206+) macrophages and the production of the M2-associated cytokines CXCL10 and CCL4 within the lung. These results suggest that consumption of BerriQi® Boysenberry and apple juice concentrate promotes a shift towards an anti-inflammatory environment within the lung leading to reduced immune cell infiltration and tissue damage.


2004 ◽  
Vol 52 (2) ◽  
pp. 201-203 ◽  
Author(s):  
Domingo Blanco Gomis ◽  
Daysi Muro Tamayo ◽  
Belén Suárez Valles ◽  
Juan J. Mangas Alonso

Food Control ◽  
2019 ◽  
Vol 97 ◽  
pp. 81-86 ◽  
Author(s):  
Megan N. Biango-Daniels ◽  
Abigail B. Snyder ◽  
Randy W. Worobo ◽  
Kathie T. Hodge

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10183 ◽  
Author(s):  
Adam A. Anas ◽  
Joppe W. R. Hovius ◽  
Cornelis van 't Veer ◽  
Tom van der Poll ◽  
Alex F. de Vos

2006 ◽  
Vol 117 (2) ◽  
pp. S49 ◽  
Author(s):  
S.S. Comstock ◽  
H. Kshirsagar ◽  
J.M. Robotham ◽  
K.H. Roux ◽  
S.K. Sathe ◽  
...  

1934 ◽  
Vol 26 (4) ◽  
pp. 449-454
Author(s):  
D. C. Carpenter ◽  
E. C. Smith

1996 ◽  
Vol 9 (1) ◽  
pp. 43-56 ◽  
Author(s):  
Edgar R. Elkins ◽  
Allen Matthys ◽  
Roy Lyon ◽  
C.J. Huang

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