scholarly journals Synthesis of middle–long–middle structured intralipids by biological catalysis and the evaluation of intralipids’ protective effect on liver injury rats

2021 ◽  
Author(s):  
Changsheng Liu ◽  
An’nan Chen ◽  
Li Xu ◽  
Tianqi Wang ◽  
Renwei Zhang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Biological Catalysis

Protective effect of Polygonum odoratum L. on acetaminophen-induced liver injury in rats

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
N Somparn ◽  
S Saenthaweesuk ◽  
R Jitvaropas ◽  
A Thuppia ◽  
J Kaulpiboon
Keyword(s):  
Liver Injury ◽  
Protective Effect

Protective effect ofAsteracantha longifoliaextract in mouse liver injury induced by carbon tetrachloride and paracetamol

2003 ◽  
Vol 55 (10) ◽  
pp. 1413-1418 ◽  
Author(s):  
R. P. Hewawasam ◽  
K. A. P. W. Jayatilaka ◽  
C. Pathirana ◽  
L. K. B. Mudduwa
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Mouse Liver

scholarly journals Protective effect of Zhuyeqing liquor, a Chinese traditional health liquor, on acute alcohol-induced liver injury in mice

2013 ◽  
Vol 10 (1) ◽  
pp. 30 ◽  
Author(s):  
Hong-ying Gao ◽  
Jian Huang ◽  
Hang-yu Wang ◽  
Xiao-wei Du ◽  
Suo-ming Cheng ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Traditional Health ◽  
Zhuyeqing Liquor

Protective effect of potato peel extract against carbon tetrachloride-induced liver injury in rats

2008 ◽  
Vol 26 (2) ◽  
pp. 241-246 ◽  
Author(s):  
Nandita Singh ◽  
Vasudeva Kamath ◽  
K. Narasimhamurthy ◽  
P.S. Rajini
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Potato Peel ◽  
Peel Extract

scholarly journals Arbutin Alleviates the Liver Injury of α-Naphthylisothiocyanate-induced Cholestasis Through Farnesoid X Receptor Activation

2021 ◽  
Vol 9 ◽  
Author(s):  
Peijie Wu ◽  
Ling Qiao ◽  
Han Yu ◽  
Hui Ming ◽  
Chao Liu ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Protective Effect ◽  
Bile Acids ◽  
Liver Toxicity ◽  
Enterohepatic Circulation ◽  
Receptor Activation ◽  
Farnesoid X Receptor ◽  
Bile Acid Metabolism ◽  
Cholestatic Diseases

Cholestasis is a kind of stressful syndrome along with liver toxicity, which has been demonstrated to be related to fibrosis, cirrhosis, even cholangiocellular or hepatocellular carcinomas. Cholestasis usually caused by the dysregulated metabolism of bile acids that possess high cellular toxicity and synthesized by cholesterol in the liver to undergo enterohepatic circulation. In cholestasis, the accumulation of bile acids in the liver causes biliary and hepatocyte injury, oxidative stress, and inflammation. The farnesoid X receptor (FXR) is regarded as a bile acid–activated receptor that regulates a network of genes involved in bile acid metabolism, providing a new therapeutic target to treat cholestatic diseases. Arbutin is a glycosylated hydroquinone isolated from medicinal plants in the genus Arctostaphylos, which has a variety of potentially pharmacological properties, such as anti-inflammatory, antihyperlipidemic, antiviral, antihyperglycemic, and antioxidant activity. However, the mechanistic contributions of arbutin to alleviate liver injury of cholestasis, especially its role on bile acid homeostasis via nuclear receptors, have not been fully elucidated. In this study, we demonstrate that arbutin has a protective effect on α-naphthylisothiocyanate–induced cholestasis via upregulation of the levels of FXR and downstream enzymes associated with bile acid homeostasis such as Bsep, Ntcp, and Sult2a1, as well as Ugt1a1. Furthermore, the regulation of these functional proteins related to bile acid homeostasis by arbutin could be alleviated by FXR silencing in L-02 cells. In conclusion, a protective effect could be supported by arbutin to alleviate ANIT-induced cholestatic liver toxicity, which was partly through the FXR pathway, suggesting arbutin may be a potential chemical molecule for the cholestatic disease.

Potential Protective Effect of Nuclear Factor-κB Decoy Oligodeoxynucleotides on Endotoxin-induced Liver Injury

2011 ◽  
Vol 43 (10) ◽  
pp. 3613-3617 ◽  
Author(s):  
J.D. Li ◽  
Y. Peng ◽  
Q. Li ◽  
J.W. Xiao ◽  
J.P. Gong ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Nuclear Factor Κb ◽  
Nuclear Factor
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