scholarly journals Lactobacillus plantarum 06CC2 reduces hepatic cholesterol levels and modulates bile acid deconjugation in Balb/c mice fed a high‐cholesterol diet

2020 ◽  
Vol 8 (11) ◽  
pp. 6164-6173
Author(s):  
Masao Yamasaki ◽  
Mikako Minesaki ◽  
Asuka Iwakiri ◽  
Yuko Miyamoto ◽  
Kenjiro Ogawa ◽  
...  
Keyword(s):  
Bile Acid ◽  
Lactobacillus Plantarum ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
Hepatic Cholesterol ◽  
High Cholesterol ◽  
Cholesterol Levels

scholarly journals The fat and protein fractions of freshwater clam (Corbicula fluminea) extract reduce serum cholesterol and enhance bile acid biosynthesis and sterol excretion in hypercholesterolaemic rats fed a high-cholesterol diet

2010 ◽  
Vol 105 (4) ◽  
pp. 526-534 ◽  
Author(s):  
Takeshi Chijimatsu ◽  
Miki Umeki ◽  
Yuji Okuda ◽  
Koji Yamada ◽  
Hiroaki Oda ◽  
...  
Keyword(s):  
Bile Acid ◽  
Serum Cholesterol ◽  
Corbicula Fluminea ◽  
Protein Fractions ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Neutral Sterols ◽  
Fat Fraction

We investigated whether the fat and protein fractions of freshwater clam (Corbicula fluminea) extract (FCE) could ameliorate hypercholesterolaemia in rats fed a high-cholesterol diet. We also explored the mechanism and the components that exert the hypocholesterolaemic effect of FCE. The doses of the fat and protein fractions were equivalent to those in 30 % FCE. The fat and protein fractions of FCE, two major components of FCE, significantly reduced the serum and hepatic cholesterol levels. The fat fraction more strongly reduced serum cholesterol levels than the same level of total FCE. The excretion of faecal neutral sterols increased in rats fed the total the FCE and the fat fraction of FCE. On the other hand, faecal bile acid levels were greater in rats fed the total FCE and the fat and protein fractions of FCE than in control animals. The hepatic gene expression of ATP-binding cassette transporter G5 and cholesterol 7α-hydroxylase was up-regulated by the administration of the total FCE and both the fat and protein fractions of FCE. These results showed that the fat and protein fractions of FCE had hypocholesterolaemic properties, and that these effects were greater with the fat fraction than with the protein fraction. The present study indicates that FCE exerts its hypocholesterolaemic effects through at least two different mechanisms, including enhanced excretion of neutral sterols and up-regulated biosynthesis of bile acids.

Tu-W23:7 Effect of high cholesterol diet on cholesterol and bile acid metabolism in A-IM and A-I transgenic mice

2006 ◽  
Vol 7 (3) ◽  
pp. 167
Author(s):  
C. Parolini ◽  
S. Caligari ◽  
D. Gilio ◽  
M. Montagnani ◽  
E.M. Rubin ◽  
...  
Keyword(s):  
Bile Acid ◽  
Transgenic Mice ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

Soybean germ oil reduces blood cholesterol by inhibiting cholesterol absorption and enhancing bile acid excretion

2019 ◽  
Vol 10 (4) ◽  
pp. 1836-1845 ◽  
Author(s):  
Hanyue Zhu ◽  
Jingnan Chen ◽  
Zouyan He ◽  
Wangjun Hao ◽  
Jianhui Liu ◽  
...  
Keyword(s):  
Bile Acid ◽  
Cholesterol Absorption ◽  
Blood Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
Acid Excretion ◽  
High Cholesterol ◽  
Bile Acid Excretion

Soybean germ oil is beneficial in management of hypercholesterolemia in hamsters fed a high cholesterol diet.

scholarly journals Phaleria macrocarpa Boerl. (Thymelaeaceae) Leaves Increase SR-BI Expression and Reduce Cholesterol Levels in Rats Fed a High Cholesterol Diet

Molecules ◽  
2015 ◽  
Vol 20 (3) ◽  
pp. 4410-4429 ◽  
Author(s):  
Yosie Andriani ◽  
Tengku Tengku-Muhammad ◽  
Habsah Mohamad ◽  
Jasnizat Saidin ◽  
Desy Syamsumir ◽  
...  
Keyword(s):  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Phaleria Macrocarpa

Effect of lactation on cholesterol synthesis in rats

1985 ◽  
Vol 249 (2) ◽  
pp. G203-G208 ◽  
Author(s):  
K. R. Feingold ◽  
A. H. Moser
Keyword(s):  
Cholesterol Synthesis ◽  
Feedback Inhibition ◽  
Tritiated Water ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
Hepatic Cholesterol ◽  
High Cholesterol ◽  
Functional Changes ◽  
Hepatic Cholesterol Synthesis ◽  
The Difference

Lactation induces a variety of morphological and functional changes in the gastrointestinal tract. In the present study we employed tritiated water as the substrate to demonstrate that in the intact rat lactation results in a twofold increase in cholesterol synthesis in the small intestine. Feeding a high-cholesterol diet did not markedly inhibit small intestinal cholesterol synthesis in either control or lactating animals, and the difference in cholesterol synthesis between the two groups persisted. In the large intestine, cholesterol synthesis is increased threefold in the lactating animals, and feeding a high-cholesterol diet did not affect synthesis in either the control or lactating animals. In the liver, lactation stimulated cholesterol synthesis, and quantitatively this increase in hepatic cholesterol synthesis is much greater than the increase observed in the intestines. Feeding the rats a high-cholesterol diet markedly inhibited hepatic cholesterol synthesis in both control and lactating animals, a finding that demonstrates that the feedback inhibition of cholesterol synthesis in the liver is not impaired by lactation. In the lactating animals, the quantity of labeled cholesterol in 1 ml of serum is 2.4 times greater than observed in controls. Feeding the rats a high-cholesterol diet markedly decreased the quantity of labeled cholesterol in the serum in both groups and obliterated the difference between control and lactating animals. This suggests that the increased hepatic cholesterol synthesis in the lactating animals is responsible for the differences in labeled cholesterol in the serum. Cholesterol feeding also reduced the quantity of labeled cholesterol localized to the mammary glands in lactating animals.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals The Effects of High Hydrostatic Pressure Extract of Mulberry Fruit on Hepatic Cholesterol Metabolism in Rats (P06-013-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Jaerin Lee ◽  
Soojin Lee ◽  
Mak-Soon Lee ◽  
Yoonjin Lee ◽  
Jiyeon Kim ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Cholesterol Metabolism ◽  
High Cholesterol Diet ◽  
Atp Binding ◽  
Mrna Levels ◽  
Cholesterol Diet ◽  
Hepatic Cholesterol ◽  
High Cholesterol ◽  
Mulberry Fruit ◽  
Atp Binding Cassette

Abstract Objectives The objective of this study is to investigate the effects of high hydrostatic pressure (HHP) extract of mulberry fruit on the regulation of hepatic cholesterol metabolism in high-cholesterol diet fed rats. Methods Male Sprague-Dawley rats(6-week-old) were randomly divided into 5 groups, and fed with a normal diet (NOR), High cholesterol diet (HC), HC supplemented with 0.4% mulberry (ML) or 0.8% mulberry (MH) and HC treated with statin (ST) for 4 weeks. Results The HHP extract of mulberry fruit did not affect body weight gain and food intake and reduced the serum and liver lipids in the mulberry supplemented groups (ML, MH). In this study, we found that the HHP extract of mulberry fruit changed the level of genes involved in hepatic cholesterol metabolism. In the MH group, the mRNA levels of apolipoprotein A-1 (apoA-1), ATP-binding cassette transporter A1 (ABCA1) and lecithin-cholesterol acyltransferase (LCAT), which are involved in hepatic HDL biogenesis, were significantly increased by 1.80-, 1.77- and 2.65-fold, respectively, compared with the HC group. The MH group also significantly upregulated mRNA levels of cholesterol efflux related gene such as the liver X receptor α (LXRα), ATP-binding cassette protein G5 (ABCG5) and ATP-binding cassette protein G8 (ABCG8) compared to the HC group in the liver tissue. ABCG5 and ABCG8 expression levels of the MH group were also higher than those of the ST group. The mRNA level of cholesterol 7a-hydroxylase (CYP7A1), which is bile acid synthetic rate-limiting enzyme was higher in the MH group than that of the HC group. Furthermore, the immunohistochemical staining intensity became evident for CYP7A1 in liver of the MH group. Conclusions These results suggest at least partial involvement of HDL cholesterol synthesis, cholesterol efflux and bile acid synthesis in HHP extract of mulberry fruit mediated beneficial effects on hepatic cholesterol metabolism. Funding Sources None.

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